Rutin (trihydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in A498 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rutin (trihydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.190195
SOD2 superoxide dismutase 2, mitochondrial 0.152684
SPTBN1 spectrin, beta, non-erythrocytic 1 0.130339
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.106424
CXCL8 chemokine (C-X-C motif) ligand 8 0.0961464
FNDC3B fibronectin type III domain containing 3B 0.091905
SMAD3 SMAD family member 3 0.0796782
NRIP1 nuclear receptor interacting protein 1 0.0755749
NRP2 neuropilin 2 0.0752534
NAV2 neuron navigator 2 0.0718554
ICAM1 intercellular adhesion molecule 1 0.0659022
CSF1 colony stimulating factor 1 (macrophage) 0.0643062
TRIO trio Rho guanine nucleotide exchange factor 0.0634484
PAX8 paired box 8 0.061082
APP amyloid beta (A4) precursor protein 0.0607881
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0598341
DENND2B DENN domain containing 2B 0.0595842
TNIP1 TNFAIP3 interacting protein 1 0.0576217
ANKRD33B ankyrin repeat domain 33B 0.056064
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0558147
VCAM1 vascular cell adhesion molecule 1 0.0555562
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0545688
MSN moesin 0.0540097
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0533017
LOXL2 lysyl oxidase-like 2 0.0518709
P3H2 prolyl 3-hydroxylase 2 0.0509518
FAT1 FAT atypical cadherin 1 0.0494796
ARHGAP26 Rho GTPase activating protein 26 0.0480852
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0471793
FLNA filamin A, alpha 0.0469856
SEPTIN9 septin 9 0.0464232
RUNX1 runt-related transcription factor 1 0.0461815
PLEC plectin 0.0460881
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0440208
G0S2 G0/G1 switch 2 0.0428401
DDIT4 DNA-damage-inducible transcript 4 0.0419224
ITGAV integrin, alpha V 0.0417401
RNF213 ring finger protein 213 0.0398355
SPAG9 sperm associated antigen 9 0.0397569
ADAM9 ADAM metallopeptidase domain 9 0.0396533
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0386416
ADAM17 ADAM metallopeptidase domain 17 0.0385202
CENPF centromere protein F, 350/400kDa 0.038242
TPM3 tropomyosin 3 0.0379976
ANLN anillin, actin binding protein 0.0370484
SP3 Sp3 transcription factor 0.0365492
ARRDC3 arrestin domain containing 3 0.0363072
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0361292
ATP13A3 ATPase type 13A3 0.0358439
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0346835
ACTN4 actinin, alpha 4 0.0345257
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0342142
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0342072
CCL2 chemokine (C-C motif) ligand 2 0.0341584
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0340267
ADAR adenosine deaminase, RNA-specific 0.0334604
MYO10 myosin X 0.0326226
ANKRD11 ankyrin repeat domain 11 0.0322987
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0322302
XPO1 exportin 1 0.0321894
EML4 echinoderm microtubule associated protein like 4 0.0319512
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0319145
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0317261
GPC6 glypican 6 0.0316241
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0315217
GPR107 G protein-coupled receptor 107 0.0312395
OPTN optineurin 0.0311611
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0309483
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0305857
RIPK2 receptor-interacting serine-threonine kinase 2 0.0303629
BIRC3 baculoviral IAP repeat containing 3 0.0302505
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0301965
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301574
BHLHE40 basic helix-loop-helix family, member e40 0.0293192
OSBPL3 oxysterol binding protein-like 3 0.0291207
KDM6A lysine (K)-specific demethylase 6A 0.0291062
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.029038
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0289253
GLS2 glutaminase 2 (liver, mitochondrial) 0.0289114
GOLGA4 golgin A4 0.0289078
LRRC59 leucine rich repeat containing 59 0.0288412
CADM1 cell adhesion molecule 1 0.0285969
SLTM SAFB-like, transcription modulator 0.0285891
ESYT2 extended synaptotagmin-like protein 2 0.0285619
SLMAP sarcolemma associated protein 0.0282377
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0279525
CLTC clathrin, heavy chain (Hc) 0.0279481
LASP1 LIM and SH3 protein 1 0.027649
PCBP2 poly(rC) binding protein 2 0.0275383
TM9SF2 transmembrane 9 superfamily member 2 0.027521
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0274349
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0273762
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0272854
RAD23B RAD23 homolog B (S. cerevisiae) 0.0264414
UBQLN1 ubiquilin 1 0.0262721
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0262173
SAMD4A sterile alpha motif domain containing 4A 0.0261401
UGCG UDP-glucose ceramide glucosyltransferase 0.0259375
MYO1B myosin IB 0.0255792
SHB Src homology 2 domain containing adaptor protein B 0.0255666

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.139685
ASPH aspartate beta-hydroxylase -0.12729
GLIS3 GLIS family zinc finger 3 -0.0808965
HLA-B major histocompatibility complex, class I, B -0.0727908
FRMD4A FERM domain containing 4A -0.066078
RPS6 ribosomal protein S6 -0.0657104
TMSB10 thymosin beta 10 -0.0592375
CP ceruloplasmin (ferroxidase) -0.0559891
TXNRD1 thioredoxin reductase 1 -0.0558759
IGFBP3 insulin-like growth factor binding protein 3 -0.0517439
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0492323
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0481817
VIM vimentin -0.0477538
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0468338
EHBP1 EH domain binding protein 1 -0.0461711
RPS8 ribosomal protein S8 -0.0433067
ACTG1 actin gamma 1 -0.0430826
B2M beta-2-microglobulin -0.0427074
TPT1 tumor protein, translationally-controlled 1 -0.0406374
GDF15 growth differentiation factor 15 -0.0386475
PALLD palladin, cytoskeletal associated protein -0.0369556
GARS1 glycyl-tRNA synthetase 1 -0.034565
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0327002
INTS6 integrator complex subunit 6 -0.0325175
RPL35A ribosomal protein L35a -0.0325014
HMGB1 high mobility group box 1 -0.0324512
TSHZ2 teashirt zinc finger homeobox 2 -0.0322183
EIF1 eukaryotic translation initiation factor 1 -0.0316266
RPLP2 ribosomal protein, large, P2 -0.0316115
RPS19 ribosomal protein S19 -0.0310276
PFN1 profilin 1 -0.0310151
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0308663
HSPB1 heat shock 27kDa protein 1 -0.0308544
RIGI RNA sensor RIG-I -0.0301137
RPLP1 ribosomal protein, large, P1 -0.0291467
MT2A metallothionein 2A -0.0284644
LOC102724023 ES1 protein homolog, mitochondrial -0.0280955
RAB2A RAB2A, member RAS oncogene family -0.0273396
RRBP1 ribosome binding protein 1 -0.0271683
SP100 SP100 nuclear antigen -0.0270944
IARS1 isoleucyl-tRNA synthetase 1 -0.027015
POTEF POTE ankyrin domain family, member F -0.0267137
CTSD cathepsin D -0.0266342
NAMPT nicotinamide phosphoribosyltransferase -0.0257834
RPL34 ribosomal protein L34 -0.0256958
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0255091
MTDH metadherin -0.0250808
HLA-C major histocompatibility complex, class I, C -0.0244914
MSR1 macrophage scavenger receptor 1 -0.0242044
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0239674
FUS FUS RNA binding protein -0.0239052
LMNA lamin A/C -0.023632
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0232906
RPL26 ribosomal protein L26 -0.0232044
NOP58 NOP58 ribonucleoprotein -0.0230602
OSMR oncostatin M receptor -0.0230115
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0226786
PDLIM5 PDZ and LIM domain 5 -0.0226385
RPS5 ribosomal protein S5 -0.0222661
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0218715
RBBP6 retinoblastoma binding protein 6 -0.0218076
IFI16 interferon, gamma-inducible protein 16 -0.0218072
MAP1B microtubule-associated protein 1B -0.0217679
CBX3 chromobox homolog 3 -0.0215606
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0214316
CALD1 caldesmon 1 -0.021046
PTMA prothymosin, alpha -0.0208212
RPS13 ribosomal protein S13 -0.0208098
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0204767
RPL31 ribosomal protein L31 -0.0204522
RPL8 ribosomal protein L8 -0.0203986
GNAS GNAS complex locus -0.0202829
RPL37A ribosomal protein L37a -0.0202787
RPL9 ribosomal protein L9 -0.020096
EIF5B eukaryotic translation initiation factor 5B -0.0198251
TBCA tubulin folding cofactor A -0.0197893
RPS24 ribosomal protein S24 -0.0197808
WSB1 WD repeat and SOCS box containing 1 -0.0196641
CAVIN1 caveolae associated protein 1 -0.0196212
XAF1 XIAP associated factor 1 -0.01943
TTC3 tetratricopeptide repeat domain 3 -0.0193778
PTH2R parathyroid hormone 2 receptor -0.0191721
OXR1 oxidation resistance 1 -0.0189596
RPL12 ribosomal protein L12 -0.0189479
LARP1B La ribonucleoprotein domain family, member 1B -0.0186631
GCLM glutamate-cysteine ligase, modifier subunit -0.0185224
RPL28 ribosomal protein L28 -0.0184939
SMYD3 SET and MYND domain containing 3 -0.0184643
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0183755
RPL7A ribosomal protein L7a -0.0182806
SERF2 small EDRK-rich factor 2 -0.0182068
VCL vinculin -0.0178238
RIC8B RIC8 guanine nucleotide exchange factor B -0.0178235
RPS27A ribosomal protein S27a -0.0176709
RND3 Rho family GTPase 3 -0.0176451
NAP1L1 nucleosome assembly protein 1-like 1 -0.0176152
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0175541
CADPS2 Ca++-dependent secretion activator 2 -0.0174399
CKAP4 cytoskeleton-associated protein 4 -0.0171947
LIMA1 LIM domain and actin binding 1 -0.0171111