Rutin (trihydrate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.228403
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.075482
TMSB4X thymosin beta 4, X-linked 0.075342
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0733265
QKI QKI, KH domain containing, RNA binding 0.0679407
PRELID2 PRELI domain containing 2 0.0616091
OGA O-GlcNAcase 0.0576266
FGFR2 fibroblast growth factor receptor 2 0.0552335
DDIT4 DNA-damage-inducible transcript 4 0.0495459
MED13L mediator complex subunit 13-like 0.0463409
USP9X ubiquitin specific peptidase 9, X-linked 0.0439009
MYH9 myosin, heavy chain 9, non-muscle 0.0390301
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0374935
EEF2 eukaryotic translation elongation factor 2 0.0363873
SFTPA2 surfactant protein A2 0.035472
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0343412
RPL3 ribosomal protein L3 0.0335594
KMT2C lysine (K)-specific methyltransferase 2C 0.0331776
FGFR1 fibroblast growth factor receptor 1 0.0329862
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0316169
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0310548
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0302939
LDHA lactate dehydrogenase A 0.0296813
CALR calreticulin 0.0296343
FLNA filamin A, alpha 0.0295496
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0288965
RREB1 ras responsive element binding protein 1 0.0283214
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0282126
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0276895
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0275671
PELI1 pellino E3 ubiquitin protein ligase 1 0.0273517
H1-2 H1.2 linker histone, cluster member 0.0267864
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264928
ZNF292 zinc finger protein 292 0.0263669
KDM3A lysine (K)-specific demethylase 3A 0.0260394
EEF1G eukaryotic translation elongation factor 1 gamma 0.0260302
TUBB tubulin, beta class I 0.0254181
HYOU1 hypoxia up-regulated 1 0.0252696
YTHDC1 YTH domain containing 1 0.0251976
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0251839
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0249749
EIF4H eukaryotic translation initiation factor 4H 0.0247255
RAD21 RAD21 homolog (S. pombe) 0.0245794
SQSTM1 sequestosome 1 0.0244662
FN1 fibronectin 1 0.0241658
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0241357
PRRC2A proline-rich coiled-coil 2A 0.0238051
TOP2B topoisomerase (DNA) II beta 180kDa 0.0237963
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.023378
MANBA mannosidase, beta A, lysosomal 0.0233029
DST dystonin 0.0232881
NCOR2 nuclear receptor corepressor 2 0.0232849
CSDE1 cold shock domain containing E1, RNA-binding 0.0231016
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0230728
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0228332
SKIC3 SKI3 subunit of superkiller complex 0.0227491
UBC ubiquitin C 0.0227129
MACO1 macoilin 1 0.0226895
EXT1 exostosin glycosyltransferase 1 0.0226253
AFDN afadin, adherens junction formation factor 0.022542
USP3 ubiquitin specific peptidase 3 0.0223816
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0223246
OPTN optineurin 0.0221514
PLS3 plastin 3 0.0221268
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.021901
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0217705
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.021464
CANX calnexin 0.0214088
USP22 ubiquitin specific peptidase 22 0.0212514
CCDC6 coiled-coil domain containing 6 0.021012
SECISBP2L SECIS binding protein 2-like 0.0208666
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0208511
TNIP1 TNFAIP3 interacting protein 1 0.0208001
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0207602
ZC3H11A zinc finger CCCH-type containing 11A 0.0206829
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0205928
HBP1 HMG-box transcription factor 1 0.0204276
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0201241
RNF130 ring finger protein 130 0.0200602
HELZ helicase with zinc finger 0.0199319
NFE2L1 nuclear factor, erythroid 2-like 1 0.0198899
SOD2 superoxide dismutase 2, mitochondrial 0.0197989
TM9SF2 transmembrane 9 superfamily member 2 0.0195359
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0194346
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0194163
PLEC plectin 0.0192978
ANKRD33B ankyrin repeat domain 33B 0.0192305
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0192176
ACTN4 actinin, alpha 4 0.0191845
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0190685
PHF21A PHD finger protein 21A 0.0190051
ARRDC3 arrestin domain containing 3 0.0188421
BHLHE40 basic helix-loop-helix family, member e40 0.0188367
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0188304
MYH10 myosin, heavy chain 10, non-muscle 0.0188269
HSPA8 heat shock 70kDa protein 8 0.0188266
FNIP1 folliculin interacting protein 1 0.0187003
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0186578
ZNF516 zinc finger protein 516 0.0186369
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0185546

decreased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I -0.163675
CADM2 cell adhesion molecule 2 -0.142871
RPS6 ribosomal protein S6 -0.135635
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0926992
HMGA2 high mobility group AT-hook 2 -0.0908796
VIM vimentin -0.0759966
TSHZ2 teashirt zinc finger homeobox 2 -0.0751744
MGP matrix Gla protein -0.0746933
RPL34 ribosomal protein L34 -0.0649823
PTMA prothymosin, alpha -0.0638894
CENPF centromere protein F, 350/400kDa -0.0638327
PDE4D phosphodiesterase 4D, cAMP-specific -0.0607763
RPLP2 ribosomal protein, large, P2 -0.05961
MT2A metallothionein 2A -0.058897
ACTG1 actin gamma 1 -0.0547305
MSRB3 methionine sulfoxide reductase B3 -0.0534014
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0533212
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0525747
SOX4 SRY (sex determining region Y)-box 4 -0.05189
WSB1 WD repeat and SOCS box containing 1 -0.0518086
IGF2 insulin-like growth factor 2 -0.0517804
RPS23 ribosomal protein S23 -0.0514076
RPS19 ribosomal protein S19 -0.0483454
JMJD1C jumonji domain containing 1C -0.0445498
RPS14 ribosomal protein S14 -0.0441821
RPL31 ribosomal protein L31 -0.0440452
GMDS GDP-mannose 4,6-dehydratase -0.0429706
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0423238
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0413881
RPLP1 ribosomal protein, large, P1 -0.0412364
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0406384
TCF12 transcription factor 12 -0.0404466
RPL37A ribosomal protein L37a -0.0403101
RPL35A ribosomal protein L35a -0.040119
RBM25 RNA binding motif protein 25 -0.0400849
ZFAND3 zinc finger, AN1-type domain 3 -0.0400011
MYOF myoferlin -0.0396932
NBEA neurobeachin -0.0394263
RPS29 ribosomal protein S29 -0.0393208
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0388371
RPS13 ribosomal protein S13 -0.0377877
RPS24 ribosomal protein S24 -0.0376883
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.037224
CENPE centromere protein E, 312kDa -0.0368805
TMSB10 thymosin beta 10 -0.0368692
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036666
FBXO11 F-box protein 11 -0.0364137
PHIP pleckstrin homology domain interacting protein -0.0362899
KTN1 kinectin 1 (kinesin receptor) -0.0357015
VCL vinculin -0.0355022
RPS3 ribosomal protein S3 -0.0352093
NAP1L1 nucleosome assembly protein 1-like 1 -0.0350887
UBXN4 UBX domain protein 4 -0.0348961
KAZN kazrin, periplakin interacting protein -0.0348851
S100A9 S100 calcium binding protein A9 -0.0348551
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0344765
RPL28 ribosomal protein L28 -0.0343012
RPS8 ribosomal protein S8 -0.0335054
BPTF bromodomain PHD finger transcription factor -0.0334965
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0333601
RPS10 ribosomal protein S10 -0.0331951
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0329284
PHF14 PHD finger protein 14 -0.0328835
RPL12 ribosomal protein L12 -0.0322642
RTN4 reticulon 4 -0.0322009
AFF4 AF4/FMR2 family, member 4 -0.0321052
RPS2 ribosomal protein S2 -0.0320818
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0315616
MAP1B microtubule-associated protein 1B -0.0314457
RANBP17 RAN binding protein 17 -0.0309316
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0307936
RPL38 ribosomal protein L38 -0.0307107
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0303303
COL1A2 collagen, type I, alpha 2 -0.0302584
TAOK1 TAO kinase 1 -0.0300013
RB1 retinoblastoma 1 -0.0299964
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0297913
RPS12 ribosomal protein S12 -0.0295273
WWC2 WW and C2 domain containing 2 -0.0285564
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0284795
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0284408
RPS15 ribosomal protein S15 -0.0281342
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0280274
TPST1 tyrosylprotein sulfotransferase 1 -0.0276772
RPL8 ribosomal protein L8 -0.0276224
DOCK3 dedicator of cytokinesis 3 -0.0274904
RPL36 ribosomal protein L36 -0.0274504
MRTFA myocardin related transcription factor A -0.0274211
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0273509
HIP1 huntingtin interacting protein 1 -0.0272734
GTF2IRD1 GTF2I repeat domain containing 1 -0.0271343
NIPBL Nipped-B homolog (Drosophila) -0.0271037
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0262245
TPK1 thiamin pyrophosphokinase 1 -0.0262177
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0259869
FUS FUS RNA binding protein -0.0259844
RPS27A ribosomal protein S27a -0.025824
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0256287
FAF1 Fas (TNFRSF6) associated factor 1 -0.0254778
MAGED1 melanoma antigen family D1 -0.0251926