Rutin (trihydrate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC17 mucin 17, cell surface associated 0.360797
FLNB filamin B, beta 0.284451
PLEC plectin 0.153936
MYH9 myosin, heavy chain 9, non-muscle 0.109512
NDRG1 N-myc downstream regulated 1 0.0975071
AKAP12 A kinase (PRKA) anchor protein 12 0.0971165
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0852792
APLP2 amyloid beta (A4) precursor-like protein 2 0.0815751
GRB10 growth factor receptor-bound protein 10 0.0788489
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0784899
UBA6 ubiquitin-like modifier activating enzyme 6 0.069633
MCL1 myeloid cell leukemia 1 0.0678514
CORO1C coronin, actin binding protein, 1C 0.0673904
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0656378
PCBP2 poly(rC) binding protein 2 0.0633838
ACTN4 actinin, alpha 4 0.0628558
ITPRID2 ITPR interacting domain containing 2 0.0624782
ERRFI1 ERBB receptor feedback inhibitor 1 0.0620614
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0614708
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0606904
PGK1 phosphoglycerate kinase 1 0.0605619
DSPP dentin sialophosphoprotein 0.0602036
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0592834
RCOR1 REST corepressor 1 0.0591702
HSPA8 heat shock 70kDa protein 8 0.0561248
TPM3 tropomyosin 3 0.0542978
MPRIP myosin phosphatase Rho interacting protein 0.0539656
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0539508
BAIAP2L1 BAI1-associated protein 2-like 1 0.0538801
FAM107B family with sequence similarity 107, member B 0.0507375
MACF1 microtubule-actin crosslinking factor 1 0.0501234
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0496798
MSN moesin 0.04797
TSC22D2 TSC22 domain family, member 2 0.0478775
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0478093
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0470074
ADAM9 ADAM metallopeptidase domain 9 0.045513
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0442069
LAMB3 laminin, beta 3 0.0437702
IGFBP3 insulin-like growth factor binding protein 3 0.0433725
ITGA6 integrin, alpha 6 0.0430093
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0429616
EZR ezrin 0.0428789
PARD3 par-3 family cell polarity regulator 0.0426744
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0423618
FMNL2 formin-like 2 0.0420335
ADAM17 ADAM metallopeptidase domain 17 0.0415375
SPAG9 sperm associated antigen 9 0.0415172
BHLHE40 basic helix-loop-helix family, member e40 0.041379
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0401298
ZEB1 zinc finger E-box binding homeobox 1 0.0398809
LAMC2 laminin, gamma 2 0.0393385
AKAP13 A kinase (PRKA) anchor protein 13 0.0384278
ESYT2 extended synaptotagmin-like protein 2 0.0381997
TNIP1 TNFAIP3 interacting protein 1 0.0381511
CAPRIN2 caprin family member 2 0.0378635
NCOR2 nuclear receptor corepressor 2 0.037266
FXR1 fragile X mental retardation, autosomal homolog 1 0.0366788
SNX9 sorting nexin 9 0.036229
KRT18 keratin 18, type I 0.0346934
PELI1 pellino E3 ubiquitin protein ligase 1 0.0342995
OGA O-GlcNAcase 0.0342387
PICALM phosphatidylinositol binding clathrin assembly protein 0.0342163
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0335547
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.033208
ARGLU1 arginine and glutamate rich 1 0.0328156
DPY19L1 dpy-19-like 1 (C. elegans) 0.0326073
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0319132
WAC WW domain containing adaptor with coiled-coil 0.0318076
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0317573
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0316722
KIRREL1 kirre like nephrin family adhesion molecule 1 0.03166
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0315203
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0298537
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0293405
F3 coagulation factor III (thromboplastin, tissue factor) 0.02911
YTHDC1 YTH domain containing 1 0.0289646
DDIT4 DNA-damage-inducible transcript 4 0.0289492
TGM2 transglutaminase 2 0.0289084
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0288941
FAM13A family with sequence similarity 13, member A 0.028891
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0287834
NUP58 nucleoporin 58 0.0286664
KDM6A lysine (K)-specific demethylase 6A 0.0284667
CTBP2 C-terminal binding protein 2 0.028242
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0277287
RPL19 ribosomal protein L19 0.0274635
CCNY cyclin Y 0.0273365
UBC ubiquitin C 0.0271313
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0270079
OSBPL9 oxysterol binding protein-like 9 0.0267287
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0267233
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.026634
TRIO trio Rho guanine nucleotide exchange factor 0.026615
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0264936
EEF2 eukaryotic translation elongation factor 2 0.0264748
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0264702
SOD2 superoxide dismutase 2, mitochondrial 0.0261537
FNDC3B fibronectin type III domain containing 3B 0.026126
SEPTIN9 septin 9 0.0260112

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.159685
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.128341
TPT1 tumor protein, translationally-controlled 1 -0.103598
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.10254
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0819442
PTPRR protein tyrosine phosphatase, receptor type, R -0.0785932
S100A10 S100 calcium binding protein A10 -0.0630291
ACTG1 actin gamma 1 -0.0512717
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0496496
PRSS3 protease, serine, 3 -0.0490411
VCAN versican -0.0488147
EFNA5 ephrin-A5 -0.0473563
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0452461
RPL34 ribosomal protein L34 -0.0433605
S100A4 S100 calcium binding protein A4 -0.0422227
GREB1L growth regulation by estrogen in breast cancer-like -0.0418323
RPL8 ribosomal protein L8 -0.0403078
RPS21 ribosomal protein S21 -0.0396624
RPL35A ribosomal protein L35a -0.0394042
RAB2A RAB2A, member RAS oncogene family -0.0385939
PTMA prothymosin, alpha -0.0383056
RPS24 ribosomal protein S24 -0.0374666
RRBP1 ribosome binding protein 1 -0.0367979
MAML2 mastermind-like 2 (Drosophila) -0.036532
SKAP2 src kinase associated phosphoprotein 2 -0.0360526
RPLP1 ribosomal protein, large, P1 -0.0353482
RPL12 ribosomal protein L12 -0.0347345
RPLP0 ribosomal protein, large, P0 -0.0346076
KLF6 Kruppel-like factor 6 -0.0342665
TXNRD1 thioredoxin reductase 1 -0.0340984
RPL30 ribosomal protein L30 -0.0329793
EHBP1 EH domain binding protein 1 -0.0325616
RPL37A ribosomal protein L37a -0.0320009
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.031403
LY6E lymphocyte antigen 6 complex, locus E -0.0312869
ZBTB20 zinc finger and BTB domain containing 20 -0.030496
RPS13 ribosomal protein S13 -0.0303709
FTL ferritin, light polypeptide -0.0301695
RPS27A ribosomal protein S27a -0.0297715
SQSTM1 sequestosome 1 -0.0290604
EPCAM epithelial cell adhesion molecule -0.0288655
LMTK2 lemur tyrosine kinase 2 -0.0288227
FTH1 ferritin, heavy polypeptide 1 -0.0278967
THOC2 THO complex 2 -0.027826
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.027733
S100A6 S100 calcium binding protein A6 -0.0271637
CALU calumenin -0.0270209
MORF4L2 mortality factor 4 like 2 -0.0267795
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0266392
MYL12B myosin, light chain 12B, regulatory -0.0265581
EIF1 eukaryotic translation initiation factor 1 -0.0262922
GNAS GNAS complex locus -0.0259327
HMGA2 high mobility group AT-hook 2 -0.0255955
GCC2 GRIP and coiled-coil domain containing 2 -0.0255615
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0255041
RACK1 receptor for activated C kinase 1 -0.0254997
PDE4D phosphodiesterase 4D, cAMP-specific -0.0251517
ANXA2 annexin A2 -0.0251116
MYOF myoferlin -0.0250794
RPS8 ribosomal protein S8 -0.0248147
RPL26 ribosomal protein L26 -0.0247638
SPATS2L spermatogenesis associated, serine-rich 2-like -0.024675
AKAP9 A kinase (PRKA) anchor protein 9 -0.0246498
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0246105
RPS3 ribosomal protein S3 -0.0244699
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240578
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0240268
CD2AP CD2-associated protein -0.0239571
RPL37 ribosomal protein L37 -0.0237163
MRPS6 mitochondrial ribosomal protein S6 -0.023641
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0235953
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0235607
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0226974
IER3 immediate early response 3 -0.0226421
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.022625
PRELID2 PRELI domain containing 2 -0.0223985
TM4SF1 transmembrane 4 L six family member 1 -0.0222851
S100A11 S100 calcium binding protein A11 -0.0222146
JMJD1C jumonji domain containing 1C -0.0218776
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0215178
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0213261
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0209758
RPL9 ribosomal protein L9 -0.0209688
ARHGAP5 Rho GTPase activating protein 5 -0.0209616
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0208684
ARF1 ADP-ribosylation factor 1 -0.0207089
RPLP2 ribosomal protein, large, P2 -0.0203517
UBE2B ubiquitin-conjugating enzyme E2B -0.0202547
IFRD1 interferon-related developmental regulator 1 -0.0201273
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.020081
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0198562
RIGI RNA sensor RIG-I -0.0197777
RPS28 ribosomal protein S28 -0.019496
RTN3 reticulon 3 -0.0191244
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0191126
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0186654
RPS6 ribosomal protein S6 -0.0186545
SDC4 syndecan 4 -0.0185191
RPL31 ribosomal protein L31 -0.0184596
IFI16 interferon, gamma-inducible protein 16 -0.0183745