Rutin (trihydrate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.120087
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0863552
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0805082
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0672518
TRIO trio Rho guanine nucleotide exchange factor 0.066279
HSPA8 heat shock 70kDa protein 8 0.0621021
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0615936
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0584361
CABIN1 calcineurin binding protein 1 0.0572933
NEBL nebulette 0.0554854
FMNL2 formin-like 2 0.0537339
KMT2C lysine (K)-specific methyltransferase 2C 0.0521839
TENM3 teneurin transmembrane protein 3 0.0503607
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0486838
HELZ helicase with zinc finger 0.0474683
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0459146
ZNF608 zinc finger protein 608 0.045442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0453995
CAMTA1 calmodulin binding transcription activator 1 0.0435299
KDM3A lysine (K)-specific demethylase 3A 0.0425631
DENND1A DENN/MADD domain containing 1A 0.0411582
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.040255
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0399396
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.039789
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0394049
FAT1 FAT atypical cadherin 1 0.0389419
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0384046
OGA O-GlcNAcase 0.0378041
NUP58 nucleoporin 58 0.0368213
NPAS3 neuronal PAS domain protein 3 0.0358322
EIF4B eukaryotic translation initiation factor 4B 0.03531
PTK2 protein tyrosine kinase 2 0.0352421
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0350105
ATP11A ATPase, class VI, type 11A 0.0348282
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0346398
RCC1 regulator of chromosome condensation 1 0.0343056
DSCAM Down syndrome cell adhesion molecule 0.0339101
APLP2 amyloid beta (A4) precursor-like protein 2 0.0338327
SMYD3 SET and MYND domain containing 3 0.033807
ARHGAP32 Rho GTPase activating protein 32 0.033273
APP amyloid beta (A4) precursor protein 0.0314839
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0311596
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0309501
MDN1 MDN1, midasin homolog (yeast) 0.0305081
MACF1 microtubule-actin crosslinking factor 1 0.0302432
KDM5C lysine (K)-specific demethylase 5C 0.0302317
PYGL phosphorylase, glycogen, liver 0.0299234
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0297148
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0296698
DHFR dihydrofolate reductase 0.0296273
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0292928
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0287874
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0285649
RPL3 ribosomal protein L3 0.0284026
PRKCE protein kinase C, epsilon 0.0283309
POU2F1 POU class 2 homeobox 1 0.0279739
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0279059
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.027806
CASC3 cancer susceptibility candidate 3 0.0277866
SFPQ splicing factor proline/glutamine-rich 0.0276123
ARFGEF3 ARFGEF family member 3 0.0275034
UBQLN1 ubiquilin 1 0.0266852
MSI2 musashi RNA-binding protein 2 0.0265103
DIDO1 death inducer-obliterator 1 0.0264734
SBF2 SET binding factor 2 0.0263863
ZNF638 zinc finger protein 638 0.0262349
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0261688
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0261379
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0260484
GYS1 glycogen synthase 1 (muscle) 0.0259338
PHF21A PHD finger protein 21A 0.0258181
RYK receptor-like tyrosine kinase 0.0257756
PTPRG protein tyrosine phosphatase, receptor type, G 0.0257386
MCL1 myeloid cell leukemia 1 0.0256926
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0256093
CKAP5 cytoskeleton associated protein 5 0.0255815
RCOR1 REST corepressor 1 0.0252663
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0251546
FNDC3B fibronectin type III domain containing 3B 0.0249575
LDHA lactate dehydrogenase A 0.0249236
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0247094
RBM33 RNA binding motif protein 33 0.0245918
BIRC6 baculoviral IAP repeat containing 6 0.0244262
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0239663
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0238188
ALMS1 Alstrom syndrome protein 1 0.0237971
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0237934
TRA2A transformer 2 alpha homolog (Drosophila) 0.0237663
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0236822
USP34 ubiquitin specific peptidase 34 0.023621
FRYL FRY-like 0.0233696
CCNY cyclin Y 0.0233376
SND1 staphylococcal nuclease and tudor domain containing 1 0.0229917
PRELID2 PRELI domain containing 2 0.0229239
TBL1X transducin (beta)-like 1X-linked 0.0228745
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0227475
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0226011
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0225636
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0225555
JARID2 jumonji, AT rich interactive domain 2 0.0224598

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146657
RPS6 ribosomal protein S6 -0.107978
ACTG1 actin gamma 1 -0.105216
PTMA prothymosin, alpha -0.08655
ADGRG6 adhesion G protein-coupled receptor G6 -0.0739259
TMSB10 thymosin beta 10 -0.0716594
RPS21 ribosomal protein S21 -0.0705206
RPLP1 ribosomal protein, large, P1 -0.0664058
RPLP2 ribosomal protein, large, P2 -0.0610613
IFI6 interferon, alpha-inducible protein 6 -0.060329
RPL34 ribosomal protein L34 -0.0583462
RPS8 ribosomal protein S8 -0.0572839
CADM2 cell adhesion molecule 2 -0.056059
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0554017
RPL12 ribosomal protein L12 -0.0551012
EGR1 early growth response 1 -0.0545075
SOX4 SRY (sex determining region Y)-box 4 -0.0541667
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0541336
RIGI RNA sensor RIG-I -0.0530465
RPL26 ribosomal protein L26 -0.0522343
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0517118
RPL28 ribosomal protein L28 -0.051031
TOX thymocyte selection-associated high mobility group box -0.0504165
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0471182
RPS24 ribosomal protein S24 -0.0455221
RAP1B RAP1B, member of RAS oncogene family -0.0450574
RPS13 ribosomal protein S13 -0.044221
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0435636
HMGB1 high mobility group box 1 -0.043419
RPL11 ribosomal protein L11 -0.0426762
WSB1 WD repeat and SOCS box containing 1 -0.0425303
RPL35A ribosomal protein L35a -0.0423321
RPL31 ribosomal protein L31 -0.041632
S100A9 S100 calcium binding protein A9 -0.041056
MYL12B myosin, light chain 12B, regulatory -0.0409901
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0406994
RPS29 ribosomal protein S29 -0.0402645
RPL9 ribosomal protein L9 -0.0390091
GNAS GNAS complex locus -0.0386054
GRID2 glutamate receptor, ionotropic, delta 2 -0.0376408
RPL23 ribosomal protein L23 -0.0367475
RPS19 ribosomal protein S19 -0.0363594
MCTP1 multiple C2 domains, transmembrane 1 -0.0357398
RPS5 ribosomal protein S5 -0.0342645
VCL vinculin -0.0341035
RPL5 ribosomal protein L5 -0.0339192
EIF5B eukaryotic translation initiation factor 5B -0.0338094
B2M beta-2-microglobulin -0.0336831
RPS14 ribosomal protein S14 -0.0334683
RPS25 ribosomal protein S25 -0.0329038
RPS15 ribosomal protein S15 -0.0327945
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0326121
H1-0 H1.0 linker histone -0.0325848
SOX5 SRY (sex determining region Y)-box 5 -0.0325057
RPL8 ribosomal protein L8 -0.0319788
RPL36 ribosomal protein L36 -0.0312988
TPT1 tumor protein, translationally-controlled 1 -0.0310617
PFN1 profilin 1 -0.0291652
RPL36A ribosomal protein L36a -0.0291636
SOX2 SRY (sex determining region Y)-box 2 -0.0291102
KTN1 kinectin 1 (kinesin receptor) -0.0290827
RPLP0 ribosomal protein, large, P0 -0.0287178
RBBP6 retinoblastoma binding protein 6 -0.0283904
RACK1 receptor for activated C kinase 1 -0.0278177
FTL ferritin, light polypeptide -0.0274785
RPL38 ribosomal protein L38 -0.0273508
PABPN1 poly(A) binding protein, nuclear 1 -0.02684
RPS27A ribosomal protein S27a -0.026767
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0267552
RPS28 ribosomal protein S28 -0.0267006
OSBPL10 oxysterol binding protein-like 10 -0.0266063
RPL37A ribosomal protein L37a -0.0264373
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0263486
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0260047
LATS2 large tumor suppressor kinase 2 -0.0258829
RPL18 ribosomal protein L18 -0.0255346
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0246389
PRICKLE1 prickle homolog 1 (Drosophila) -0.0244911
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0238246
RPS3 ribosomal protein S3 -0.0236155
ATP5F1B ATP synthase F1 subunit beta -0.0233566
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0233102
RPL7A ribosomal protein L7a -0.0231048
PMP22 peripheral myelin protein 22 -0.0229055
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0228671
POTEF POTE ankyrin domain family, member F -0.0226949
RPL19 ribosomal protein L19 -0.0225173
HLA-B major histocompatibility complex, class I, B -0.0222997
RBM25 RNA binding motif protein 25 -0.0217201
RPS11 ribosomal protein S11 -0.0216725
ATP5F1E ATP synthase F1 subunit epsilon -0.0216474
ZBTB20 zinc finger and BTB domain containing 20 -0.0215647
VIM vimentin -0.0215496
KPNB1 karyopherin (importin) beta 1 -0.0215217
ISG15 ISG15 ubiquitin-like modifier -0.0213033
TBCA tubulin folding cofactor A -0.0211401
RPL32 ribosomal protein L32 -0.0208587
RPL35 ribosomal protein L35 -0.0207162
KLHL5 kelch-like family member 5 -0.0205573
NBEA neurobeachin -0.0204337