Rutin (trihydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.265047
CD109 CD109 molecule 0.114302
NAMPT nicotinamide phosphoribosyltransferase 0.0960161
VGF VGF nerve growth factor inducible 0.0873538
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0862832
NAV2 neuron navigator 2 0.0752415
CDC73 cell division cycle 73 0.0629094
FMNL2 formin-like 2 0.0624699
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0606485
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0580743
LEF1 lymphoid enhancer-binding factor 1 0.0548915
ESYT2 extended synaptotagmin-like protein 2 0.0546234
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0536485
KMT2C lysine (K)-specific methyltransferase 2C 0.0535705
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0484122
ZNF292 zinc finger protein 292 0.0477571
APP amyloid beta (A4) precursor protein 0.0470954
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.043559
CABIN1 calcineurin binding protein 1 0.043062
PHF21A PHD finger protein 21A 0.0415337
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0408909
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0408195
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0398324
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0395107
NUP58 nucleoporin 58 0.0389199
HELZ helicase with zinc finger 0.0386288
RNF145 ring finger protein 145 0.0386008
FBXO7 F-box protein 7 0.038214
SMAD3 SMAD family member 3 0.0354379
CHSY1 chondroitin sulfate synthase 1 0.0353916
BHLHE40 basic helix-loop-helix family, member e40 0.0338336
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.03248
ARRDC3 arrestin domain containing 3 0.0324368
RBM33 RNA binding motif protein 33 0.0324257
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0322716
IGFBP3 insulin-like growth factor binding protein 3 0.0310508
MYO10 myosin X 0.0308729
FNDC3B fibronectin type III domain containing 3B 0.0303793
IGF1R insulin-like growth factor 1 receptor 0.0301971
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0300373
OGA O-GlcNAcase 0.0294698
NDRG1 N-myc downstream regulated 1 0.0294656
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0278415
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0278118
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0267612
TMEM178B transmembrane protein 178B 0.026736
SSBP3 single stranded DNA binding protein 3 0.0263368
MIDEAS mitotic deacetylase associated SANT domain protein 0.0251707
DDIT4 DNA-damage-inducible transcript 4 0.0248566
RYBP RING1 and YY1 binding protein 0.0248497
JARID2 jumonji, AT rich interactive domain 2 0.0247567
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0245969
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0244334
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0243726
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0240968
C1ORF21 chromosome 1 open reading frame 21 0.0239902
AFDN afadin, adherens junction formation factor 0.0239719
COPA coatomer protein complex, subunit alpha 0.0238847
RAD23B RAD23 homolog B (S. cerevisiae) 0.0236291
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0234825
AHR aryl hydrocarbon receptor 0.0232025
VGLL4 vestigial-like family member 4 0.0231354
ACTN4 actinin, alpha 4 0.0229963
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0229915
RNF213 ring finger protein 213 0.0229381
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0228919
IL1RAP interleukin 1 receptor accessory protein 0.0227922
XPO1 exportin 1 0.0226108
SPRED1 sprouty-related, EVH1 domain containing 1 0.0225906
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0224884
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.022473
PRELID2 PRELI domain containing 2 0.0222289
FRMD6 FERM domain containing 6 0.0222168
FOXJ3 forkhead box J3 0.0218798
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0217549
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0216674
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0216476
PTK2 protein tyrosine kinase 2 0.0216113
UBE2H ubiquitin-conjugating enzyme E2H 0.0213701
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0213621
SAMD4A sterile alpha motif domain containing 4A 0.0210599
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0209764
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0207809
ETV3 ets variant 3 0.0207774
CLMN calmin (calponin-like, transmembrane) 0.0201512
ICAM1 intercellular adhesion molecule 1 0.0197524
PI15 peptidase inhibitor 15 0.0197265
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0196886
KMT2E lysine (K)-specific methyltransferase 2E 0.0193204
KDM3A lysine (K)-specific demethylase 3A 0.0190698
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0190693
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.018958
SEPTIN9 septin 9 0.0187865
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0187238
USP3 ubiquitin specific peptidase 3 0.0186591
NEK7 NIMA-related kinase 7 0.0186494
MCL1 myeloid cell leukemia 1 0.0186216
RPL3 ribosomal protein L3 0.0186156
NBAS neuroblastoma amplified sequence 0.0184544
INSIG1 insulin induced gene 1 0.0184389

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.482905
VIM vimentin -0.172594
MT2A metallothionein 2A -0.163751
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.116142
IFI16 interferon, gamma-inducible protein 16 -0.105082
ACTG1 actin gamma 1 -0.0952936
TMSB10 thymosin beta 10 -0.0948624
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0928771
HLA-B major histocompatibility complex, class I, B -0.0864989
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0853395
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0802505
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0786822
IGFBP5 insulin-like growth factor binding protein 5 -0.074655
RPLP1 ribosomal protein, large, P1 -0.0623764
S100A6 S100 calcium binding protein A6 -0.0583691
POTEF POTE ankyrin domain family, member F -0.0578332
EGR1 early growth response 1 -0.0569678
FTL ferritin, light polypeptide -0.0560699
PTMA prothymosin, alpha -0.0502376
IER3 immediate early response 3 -0.0498296
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0485422
RPS8 ribosomal protein S8 -0.0447769
RPS19 ribosomal protein S19 -0.0439528
RPL37A ribosomal protein L37a -0.043939
RPLP2 ribosomal protein, large, P2 -0.0423108
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0418168
S100A9 S100 calcium binding protein A9 -0.0415044
RPS6 ribosomal protein S6 -0.0389234
TPT1 tumor protein, translationally-controlled 1 -0.0382566
LMNA lamin A/C -0.0378973
CALU calumenin -0.0371524
AKAP9 A kinase (PRKA) anchor protein 9 -0.0370988
LOC102724023 ES1 protein homolog, mitochondrial -0.0369822
PTCHD4 patched domain containing 4 -0.0367474
IFITM3 interferon induced transmembrane protein 3 -0.0365117
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0364907
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0347843
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0345403
B2M beta-2-microglobulin -0.0343894
IFI6 interferon, alpha-inducible protein 6 -0.0337075
VDAC1 voltage-dependent anion channel 1 -0.0332834
RPL35A ribosomal protein L35a -0.0329492
DCT dopachrome tautomerase -0.0328761
GDF15 growth differentiation factor 15 -0.0328716
CTSD cathepsin D -0.0320766
CALD1 caldesmon 1 -0.0313193
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0298981
MT1X metallothionein 1X -0.02989
RPL36 ribosomal protein L36 -0.0297534
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0296116
RPL34 ribosomal protein L34 -0.029589
RPL9 ribosomal protein L9 -0.0295081
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0290147
S100A10 S100 calcium binding protein A10 -0.028612
RPS12 ribosomal protein S12 -0.0282545
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0279655
FRMD4A FERM domain containing 4A -0.0279029
GPC6 glypican 6 -0.0277236
MTDH metadherin -0.027594
TM4SF1 transmembrane 4 L six family member 1 -0.0275842
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0273297
RPL11 ribosomal protein L11 -0.0273185
TAGLN2 transgelin 2 -0.0266399
LOC112694756 uncharaterized LOC112694756 -0.0265873
HSPB1 heat shock 27kDa protein 1 -0.0264514
RPS24 ribosomal protein S24 -0.0263392
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0261135
RRBP1 ribosome binding protein 1 -0.0259444
KTN1 kinectin 1 (kinesin receptor) -0.0255711
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.025388
RPL31 ribosomal protein L31 -0.0253086
RPL30 ribosomal protein L30 -0.0253043
ENO1 enolase 1, (alpha) -0.0251901
RPL12 ribosomal protein L12 -0.0251593
RPS13 ribosomal protein S13 -0.024911
RPL8 ribosomal protein L8 -0.0237984
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0237742
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0236977
HIP1 huntingtin interacting protein 1 -0.0235026
SEPTIN7 septin 7 -0.0232557
NLGN1 neuroligin 1 -0.0230763
IFITM1 interferon induced transmembrane protein 1 -0.0229762
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0227833
RPL28 ribosomal protein L28 -0.0227284
BPTF bromodomain PHD finger transcription factor -0.0226217
CD63 CD63 molecule -0.0225467
ZBTB20 zinc finger and BTB domain containing 20 -0.0221343
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0220107
RPLP0 ribosomal protein, large, P0 -0.0219673
RPS3 ribosomal protein S3 -0.021872
RPL32 ribosomal protein L32 -0.0218629
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0217491
EHBP1 EH domain binding protein 1 -0.0216264
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0216156
ANKRD12 ankyrin repeat domain 12 -0.0215181
EIF1 eukaryotic translation initiation factor 1 -0.0214801
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0214281
RPL23 ribosomal protein L23 -0.0213359
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0212534
RPS21 ribosomal protein S21 -0.0210687