Rutin (trihydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rutin (trihydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEPTIN9 septin 9 0.0913676
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0773111
FNDC3B fibronectin type III domain containing 3B 0.0723111
FAM13A family with sequence similarity 13, member A 0.0680494
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0585609
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.05005
MYH9 myosin, heavy chain 9, non-muscle 0.0464389
HELZ helicase with zinc finger 0.0451359
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.044442
CENPF centromere protein F, 350/400kDa 0.0441636
DST dystonin 0.0438419
NAMPT nicotinamide phosphoribosyltransferase 0.0437119
XPO1 exportin 1 0.0435173
ZNF148 zinc finger protein 148 0.0418839
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0418417
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0377732
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0356096
PLAT plasminogen activator, tissue 0.0349593
WAC WW domain containing adaptor with coiled-coil 0.0342408
EXT1 exostosin glycosyltransferase 1 0.033608
NRG1 neuregulin 1 0.0332524
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0326136
SSBP3 single stranded DNA binding protein 3 0.0315081
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0311054
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0299483
SLITRK6 SLIT and NTRK-like family, member 6 0.0292
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0291539
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0290211
TNIP1 TNFAIP3 interacting protein 1 0.0285571
SOD2 superoxide dismutase 2, mitochondrial 0.0281909
GSK3B glycogen synthase kinase 3 beta 0.0277901
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0277683
CSNK1A1 casein kinase 1, alpha 1 0.027554
PDE4D phosphodiesterase 4D, cAMP-specific 0.0275
HOOK2 hook microtubule-tethering protein 2 0.0272112
SMAD3 SMAD family member 3 0.0271854
NDRG1 N-myc downstream regulated 1 0.0261295
MKI67 marker of proliferation Ki-67 0.0257765
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0243982
COPA coatomer protein complex, subunit alpha 0.0243424
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0241486
YAP1 Yes-associated protein 1 0.0241361
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0240173
ANKRD11 ankyrin repeat domain 11 0.023952
MEF2A myocyte enhancer factor 2A 0.023853
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0237455
PRPF8 pre-mRNA processing factor 8 0.0236228
ACLY ATP citrate lyase 0.0235628
ARGLU1 arginine and glutamate rich 1 0.0234492
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0233246
RPL3 ribosomal protein L3 0.0229646
RBM33 RNA binding motif protein 33 0.0226044
PRKCE protein kinase C, epsilon 0.0221895
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0221098
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0220094
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0219126
HSPA8 heat shock 70kDa protein 8 0.0217089
PCBP2 poly(rC) binding protein 2 0.0215573
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0215548
SNX13 sorting nexin 13 0.0214849
FRMD6 FERM domain containing 6 0.0214762
EWSR1 EWS RNA-binding protein 1 0.0214175
IQGAP1 IQ motif containing GTPase activating protein 1 0.0212968
PFKP phosphofructokinase, platelet 0.0210714
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0210133
UBAP2L ubiquitin associated protein 2-like 0.0209984
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0209576
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0209487
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.0207724
INSIG2 insulin induced gene 2 0.020764
USP34 ubiquitin specific peptidase 34 0.0207091
EVL Enah/Vasp-like 0.0207026
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0206706
MSMO1 methylsterol monooxygenase 1 0.0206154
DNMBP dynamin binding protein 0.0204206
AFDN afadin, adherens junction formation factor 0.0203864
VEGFA vascular endothelial growth factor A 0.0201373
SSBP2 single-stranded DNA binding protein 2 0.0201257
PLEC plectin 0.0198492
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0197764
ZMIZ1 zinc finger, MIZ-type containing 1 0.0196986
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0196541
TPM3 tropomyosin 3 0.0192698
TRIO trio Rho guanine nucleotide exchange factor 0.0192307
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.019158
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0191297
MACF1 microtubule-actin crosslinking factor 1 0.0191185
NREP neuronal regeneration related protein 0.0189424
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0189267
TM9SF2 transmembrane 9 superfamily member 2 0.0188946
CABIN1 calcineurin binding protein 1 0.0187787
PICALM phosphatidylinositol binding clathrin assembly protein 0.018746
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0187202
PGK1 phosphoglycerate kinase 1 0.0187148
SEC23A Sec23 homolog A (S. cerevisiae) 0.0186625
YTHDC1 YTH domain containing 1 0.0185072
TOP2B topoisomerase (DNA) II beta 180kDa 0.0184826
NUP58 nucleoporin 58 0.0183854
ATXN1 ataxin 1 0.0183635
UBQLN1 ubiquilin 1 0.0182627

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.405954
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.348973
PTMA prothymosin, alpha -0.150986
VIM vimentin -0.134329
RPS6 ribosomal protein S6 -0.12262
ACTG1 actin gamma 1 -0.116383
RPL23 ribosomal protein L23 -0.110151
RPL35A ribosomal protein L35a -0.0874814
RPLP1 ribosomal protein, large, P1 -0.0866903
SYT1 synaptotagmin I -0.0823492
EIF1 eukaryotic translation initiation factor 1 -0.0777507
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0771307
RPL34 ribosomal protein L34 -0.0769571
COL1A1 collagen, type I, alpha 1 -0.075654
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.07527
TPT1 tumor protein, translationally-controlled 1 -0.0747611
BPTF bromodomain PHD finger transcription factor -0.0621002
VCL vinculin -0.0610222
RPL38 ribosomal protein L38 -0.05608
RPS19 ribosomal protein S19 -0.0555534
RPS24 ribosomal protein S24 -0.0544709
MAP1B microtubule-associated protein 1B -0.0531849
AKAP12 A kinase (PRKA) anchor protein 12 -0.0513895
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0505252
IER3 immediate early response 3 -0.0505115
TMSB10 thymosin beta 10 -0.050274
FTL ferritin, light polypeptide -0.0495401
RPL36 ribosomal protein L36 -0.0478386
RPL19 ribosomal protein L19 -0.0469739
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0457682
FNBP1 formin binding protein 1 -0.045756
S100A6 S100 calcium binding protein A6 -0.0443106
RACK1 receptor for activated C kinase 1 -0.0428432
RPLP0 ribosomal protein, large, P0 -0.0423726
RPS27A ribosomal protein S27a -0.041855
MBD5 methyl-CpG binding domain protein 5 -0.0417127
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.041328
RPL31 ribosomal protein L31 -0.0401248
NCAM2 neural cell adhesion molecule 2 -0.039592
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0386742
PCDH9 protocadherin 9 -0.0386628
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0358555
RPL32 ribosomal protein L32 -0.0356276
RPS14 ribosomal protein S14 -0.0355733
RPL35 ribosomal protein L35 -0.0355128
RPS29 ribosomal protein S29 -0.0344699
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0344054
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0342213
RPL12 ribosomal protein L12 -0.03417
PTPRD protein tyrosine phosphatase, receptor type, D -0.0338092
PKM pyruvate kinase, muscle -0.0335207
RPS3 ribosomal protein S3 -0.0333421
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0330175
RPS15 ribosomal protein S15 -0.0327997
KPNB1 karyopherin (importin) beta 1 -0.0324986
RPS8 ribosomal protein S8 -0.0324976
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.032448
RPS27 ribosomal protein S27 -0.0320107
RPS21 ribosomal protein S21 -0.0320105
RPS25 ribosomal protein S25 -0.0316063
S100A9 S100 calcium binding protein A9 -0.030926
VDAC1 voltage-dependent anion channel 1 -0.0308109
EGR1 early growth response 1 -0.0305614
RHOBTB3 Rho-related BTB domain containing 3 -0.0304201
H3-3B H3.3 histone B -0.0297486
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0297099
LSAMP limbic system-associated membrane protein -0.0296889
LMNA lamin A/C -0.0294295
HAND2 heart and neural crest derivatives expressed 2 -0.0291251
RPS23 ribosomal protein S23 -0.0291125
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0287882
RSL1D1 ribosomal L1 domain containing 1 -0.0287632
RPL27 ribosomal protein L27 -0.0284219
RPL30 ribosomal protein L30 -0.0280886
TPI1 triosephosphate isomerase 1 -0.0279804
NAP1L1 nucleosome assembly protein 1-like 1 -0.027822
RPL7A ribosomal protein L7a -0.0275689
CADM2 cell adhesion molecule 2 -0.0272883
FBXL20 F-box and leucine-rich repeat protein 20 -0.0272289
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0271243
RPL37 ribosomal protein L37 -0.0268036
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0266471
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0265527
MBTD1 mbt domain containing 1 -0.0265456
BCAS3 breast carcinoma amplified sequence 3 -0.0261804
ARF1 ADP-ribosylation factor 1 -0.0261542
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0260961
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0257367
IARS1 isoleucyl-tRNA synthetase 1 -0.0253295
CCNI cyclin I -0.0252085
RPL26 ribosomal protein L26 -0.0251522
CALD1 caldesmon 1 -0.0251382
GDF15 growth differentiation factor 15 -0.0248968
CEP350 centrosomal protein 350kDa -0.0246646
TENT5A terminal nucleotidyltransferase 5A -0.0246251
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0244087
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.024284
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0242537
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0240944
HMGA1 high mobility group AT-hook 1 -0.0239036