Rutin (trihydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.105064
MYH9 myosin, heavy chain 9, non-muscle 0.0967863
NDRG1 N-myc downstream regulated 1 0.0772138
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0551755
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0545252
DDIT4 DNA-damage-inducible transcript 4 0.0451404
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0427234
YEATS2 YEATS domain containing 2 0.0422647
PRELID2 PRELI domain containing 2 0.0410686
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0398928
TMF1 TATA element modulatory factor 1 0.0393313
NUP58 nucleoporin 58 0.0392356
GOLGA4 golgin A4 0.0360195
TBC1D22A TBC1 domain family, member 22A 0.0347364
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0345902
ZNF292 zinc finger protein 292 0.0333823
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0321325
HELZ helicase with zinc finger 0.032089
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0312583
DSPP dentin sialophosphoprotein 0.0302043
SEC31A SEC31 homolog A (S. cerevisiae) 0.0297074
KRT18 keratin 18, type I 0.0295581
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0289035
PLEC plectin 0.0280086
ARL5B ADP-ribosylation factor-like 5B 0.0274711
KDM7A lysine (K)-specific demethylase 7A 0.0272362
FNIP1 folliculin interacting protein 1 0.0268854
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0268125
ESYT2 extended synaptotagmin-like protein 2 0.026534
VEGFA vascular endothelial growth factor A 0.0263689
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0262676
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0260774
UBA6 ubiquitin-like modifier activating enzyme 6 0.0260116
FAM117B family with sequence similarity 117, member B 0.0258438
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0249632
FOXO3 forkhead box O3 0.0239695
SUCO SUN domain containing ossification factor 0.0227533
PFKP phosphofructokinase, platelet 0.0227421
GOLGA3 golgin A3 0.0227001
MAP2K1 mitogen-activated protein kinase kinase 1 0.0225767
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0223018
RAD51B RAD51 paralog B 0.0220842
GOLGA2 golgin A2 0.0219623
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0219397
INSIG2 insulin induced gene 2 0.0219097
KMT2C lysine (K)-specific methyltransferase 2C 0.0219018
HOOK2 hook microtubule-tethering protein 2 0.0215295
TMEM39A transmembrane protein 39A 0.0213493
RLF rearranged L-myc fusion 0.0210494
SHB Src homology 2 domain containing adaptor protein B 0.0209332
SND1 staphylococcal nuclease and tudor domain containing 1 0.0207462
ANKRD11 ankyrin repeat domain 11 0.0206838
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0201785
GOLGB1 golgin B1 0.0201304
ARRDC3 arrestin domain containing 3 0.0201269
OGA O-GlcNAcase 0.0199323
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0197711
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0197331
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0195813
AVL9 AVL9 homolog (S. cerevisiase) 0.0194887
WDR26 WD repeat domain 26 0.0190976
RPL3 ribosomal protein L3 0.0188325
BHLHE40 basic helix-loop-helix family, member e40 0.0186233
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.018605
HDLBP high density lipoprotein binding protein 0.018579
MIMS1 mitochondrial inner membrane scaffold 1 0.018579
CORO1C coronin, actin binding protein, 1C 0.0185769
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0184191
ARGLU1 arginine and glutamate rich 1 0.0183188
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0181307
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0180191
NUMA1 nuclear mitotic apparatus protein 1 0.0180057
EIF4B eukaryotic translation initiation factor 4B 0.0179206
SBF2 SET binding factor 2 0.0179096
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0178838
SPAG9 sperm associated antigen 9 0.0175729
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.017528
RAD23B RAD23 homolog B (S. cerevisiae) 0.0175089
LASP1 LIM and SH3 protein 1 0.0173681
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0172723
MYO1B myosin IB 0.017271
SFXN1 sideroflexin 1 0.0172634
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0172556
NBAS neuroblastoma amplified sequence 0.0170151
COPB1 coatomer protein complex, subunit beta 1 0.0167293
DAND5 DAN domain family member 5, BMP antagonist 0.0167081
SRP54 signal recognition particle 54kDa 0.0166565
RUNX1 runt-related transcription factor 1 0.0164811
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0164061
SEC24A SEC24 family member A 0.016307
CLTC clathrin, heavy chain (Hc) 0.0161073
COG6 component of oligomeric golgi complex 6 0.0160007
SEC24D SEC24 family member D 0.0159837
RNMT RNA (guanine-7-) methyltransferase 0.015942
TM9SF2 transmembrane 9 superfamily member 2 0.0158352
ARF4 ADP-ribosylation factor 4 0.0158243
LRRC59 leucine rich repeat containing 59 0.0157786
COPG1 coatomer protein complex, subunit gamma 1 0.0156829
MON2 MON2 homolog (S. cerevisiae) 0.0156508
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0156324

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.476306
PTMA prothymosin, alpha -0.189786
AHNAK AHNAK nucleoprotein -0.157715
TPT1 tumor protein, translationally-controlled 1 -0.141853
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.133521
TMSB10 thymosin beta 10 -0.12394
RPS6 ribosomal protein S6 -0.112199
RPS8 ribosomal protein S8 -0.0899556
RPL35A ribosomal protein L35a -0.0884302
RPS27A ribosomal protein S27a -0.0761513
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0709918
ENO1 enolase 1, (alpha) -0.0669482
UBC ubiquitin C -0.0643326
PKM pyruvate kinase, muscle -0.0634439
FTL ferritin, light polypeptide -0.0624995
POTEF POTE ankyrin domain family, member F -0.0611824
RPLP1 ribosomal protein, large, P1 -0.0577075
RPLP2 ribosomal protein, large, P2 -0.0563642
RPL23 ribosomal protein L23 -0.0552561
S100A10 S100 calcium binding protein A10 -0.0552478
RPL34 ribosomal protein L34 -0.054932
RPS3 ribosomal protein S3 -0.0547572
ACTG1 actin gamma 1 -0.0530918
RPS13 ribosomal protein S13 -0.0502476
RPL31 ribosomal protein L31 -0.0494297
RPS24 ribosomal protein S24 -0.0476827
MT2A metallothionein 2A -0.0465937
RPL8 ribosomal protein L8 -0.0459753
RPL26 ribosomal protein L26 -0.0457438
RPS15 ribosomal protein S15 -0.0454332
S100A9 S100 calcium binding protein A9 -0.0448314
TPM4 tropomyosin 4 -0.0442335
RPL37A ribosomal protein L37a -0.0431221
RPLP0 ribosomal protein, large, P0 -0.0425879
RPS19 ribosomal protein S19 -0.0420125
RPL7A ribosomal protein L7a -0.0418652
EGR1 early growth response 1 -0.0412175
RPS29 ribosomal protein S29 -0.0411184
FUS FUS RNA binding protein -0.0398441
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0381431
FAT1 FAT atypical cadherin 1 -0.0379638
RPS25 ribosomal protein S25 -0.0367483
RPS12 ribosomal protein S12 -0.0365109
RACK1 receptor for activated C kinase 1 -0.03641
EPCAM epithelial cell adhesion molecule -0.0354404
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0347785
RPL32 ribosomal protein L32 -0.0346533
RPL38 ribosomal protein L38 -0.0345965
RPL5 ribosomal protein L5 -0.0345431
RPL12 ribosomal protein L12 -0.0339245
RPL11 ribosomal protein L11 -0.0332643
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0332178
HLA-B major histocompatibility complex, class I, B -0.0331322
PDIA3 protein disulfide isomerase family A, member 3 -0.0330191
RPS21 ribosomal protein S21 -0.0329719
INTS6 integrator complex subunit 6 -0.0328934
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0326029
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0324478
RPL15 ribosomal protein L15 -0.0323067
RPL37 ribosomal protein L37 -0.0321832
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0317124
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.031656
RPL9 ribosomal protein L9 -0.0315568
BPTF bromodomain PHD finger transcription factor -0.0313826
FAF1 Fas (TNFRSF6) associated factor 1 -0.0307342
RPS5 ribosomal protein S5 -0.030496
RBM25 RNA binding motif protein 25 -0.030429
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0301063
RPL28 ribosomal protein L28 -0.0300982
RPL36 ribosomal protein L36 -0.0298495
CCNI cyclin I -0.0294142
RPS23 ribosomal protein S23 -0.0292024
RPS10 ribosomal protein S10 -0.0289964
TPI1 triosephosphate isomerase 1 -0.0289575
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0284024
PERP PERP, TP53 apoptosis effector -0.0283379
VCL vinculin -0.028325
RPS14 ribosomal protein S14 -0.0281866
KTN1 kinectin 1 (kinesin receptor) -0.0281279
RPL18 ribosomal protein L18 -0.0270022
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0267755
HLA-A major histocompatibility complex, class I, A -0.0267574
NAP1L1 nucleosome assembly protein 1-like 1 -0.0261406
RPS16 ribosomal protein S16 -0.0259207
LDHB lactate dehydrogenase B -0.0258319
KPNB1 karyopherin (importin) beta 1 -0.0255657
EIF5B eukaryotic translation initiation factor 5B -0.0254409
RPS11 ribosomal protein S11 -0.0247592
VDAC1 voltage-dependent anion channel 1 -0.0247517
WSB1 WD repeat and SOCS box containing 1 -0.0243739
CCND1 cyclin D1 -0.0243371
GLG1 golgi glycoprotein 1 -0.0243251
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0242784
RPS17 ribosomal protein S17 -0.0239993
S100A6 S100 calcium binding protein A6 -0.0238714
SPDYA speedy/RINGO cell cycle regulator family member A -0.0238268
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0234123
GPHN gephyrin -0.0233821
TBCA tubulin folding cofactor A -0.0232346
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0230804