Rutin (trihydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.12905
FNDC3B fibronectin type III domain containing 3B 0.100171
FLNB filamin B, beta 0.0928698
SMAD3 SMAD family member 3 0.0897146
APP amyloid beta (A4) precursor protein 0.0886544
PLEC plectin 0.0822451
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0772431
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0697227
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0687935
PRELID2 PRELI domain containing 2 0.0677814
FLNA filamin A, alpha 0.0648699
IGFBP3 insulin-like growth factor binding protein 3 0.0635074
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0625663
MACF1 microtubule-actin crosslinking factor 1 0.0541723
PAX8 paired box 8 0.0541215
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0534038
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0533323
LPP LIM domain containing preferred translocation partner in lipoma 0.0527711
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0522708
HELZ helicase with zinc finger 0.0515059
TRIO trio Rho guanine nucleotide exchange factor 0.0506273
AHNAK AHNAK nucleoprotein 0.0490067
ERRFI1 ERBB receptor feedback inhibitor 1 0.0487201
NDRG1 N-myc downstream regulated 1 0.0477307
FHIT fragile histidine triad 0.0459376
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0455912
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.044131
ACTN4 actinin, alpha 4 0.0439033
BHLHE40 basic helix-loop-helix family, member e40 0.0427199
RAD51B RAD51 paralog B 0.0417018
FMNL2 formin-like 2 0.0410186
PSD3 pleckstrin and Sec7 domain containing 3 0.0408818
DDIT4 DNA-damage-inducible transcript 4 0.0402021
EGFR epidermal growth factor receptor 0.0396183
TMSB4X thymosin beta 4, X-linked 0.0396026
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0393124
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.039165
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0386022
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0372372
PTK2 protein tyrosine kinase 2 0.0363335
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0363207
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0362938
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0358793
CTBP2 C-terminal binding protein 2 0.0358198
TNIP1 TNFAIP3 interacting protein 1 0.0355169
SOD2 superoxide dismutase 2, mitochondrial 0.0351183
KDM3A lysine (K)-specific demethylase 3A 0.034205
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0340314
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0333979
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0330851
OGA O-GlcNAcase 0.0330725
OSBPL10 oxysterol binding protein-like 10 0.0328934
USP9X ubiquitin specific peptidase 9, X-linked 0.0324672
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0310096
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0302061
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0300012
SEPTIN9 septin 9 0.029907
BCAR3 breast cancer anti-estrogen resistance 3 0.0298236
ZFAND3 zinc finger, AN1-type domain 3 0.0294299
ANO6 anoctamin 6 0.0292813
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0292256
CALR calreticulin 0.029149
LAMB3 laminin, beta 3 0.0289633
SPAG9 sperm associated antigen 9 0.0287972
YEATS2 YEATS domain containing 2 0.0287001
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0286895
AFDN afadin, adherens junction formation factor 0.0283636
SBF2 SET binding factor 2 0.0281742
HSPA8 heat shock 70kDa protein 8 0.0275666
MSI2 musashi RNA-binding protein 2 0.0275388
CORO1C coronin, actin binding protein, 1C 0.0275154
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0274816
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0274709
SHB Src homology 2 domain containing adaptor protein B 0.0274208
MYOF myoferlin 0.0271958
EZR ezrin 0.0271787
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0271064
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0269962
ASPH aspartate beta-hydroxylase 0.0266334
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0263967
SQSTM1 sequestosome 1 0.0263889
ZC3H11A zinc finger CCCH-type containing 11A 0.0263596
LDHA lactate dehydrogenase A 0.0262704
SMYD3 SET and MYND domain containing 3 0.0262045
ATXN1 ataxin 1 0.0259496
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0256496
MPRIP myosin phosphatase Rho interacting protein 0.0255385
ANXA1 annexin A1 0.0254807
ADAM9 ADAM metallopeptidase domain 9 0.0254785
AKAP13 A kinase (PRKA) anchor protein 13 0.0254707
ANKRD11 ankyrin repeat domain 11 0.0254264
DIAPH1 diaphanous-related formin 1 0.0251512
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0248869
ANKRD10 ankyrin repeat domain 10 0.0248636
RAD23B RAD23 homolog B (S. cerevisiae) 0.0247643
DSPP dentin sialophosphoprotein 0.024726
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0245376
UTRN utrophin 0.0244509
RNF213 ring finger protein 213 0.0244136
ANXA2 annexin A2 0.0242554

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.156599
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149561
TMSB10 thymosin beta 10 -0.11942
ACTG1 actin gamma 1 -0.115234
FTL ferritin, light polypeptide -0.0988847
RPS6 ribosomal protein S6 -0.0910101
RPL35A ribosomal protein L35a -0.0832105
TPT1 tumor protein, translationally-controlled 1 -0.0637414
RPS19 ribosomal protein S19 -0.0577452
POTEF POTE ankyrin domain family, member F -0.0542308
RPLP1 ribosomal protein, large, P1 -0.0517677
RPL23 ribosomal protein L23 -0.0500727
RPL12 ribosomal protein L12 -0.0492032
PTMA prothymosin, alpha -0.0447693
RPS8 ribosomal protein S8 -0.0447461
B2M beta-2-microglobulin -0.0422496
RPL32 ribosomal protein L32 -0.0414328
S100A9 S100 calcium binding protein A9 -0.0410188
RPLP0 ribosomal protein, large, P0 -0.0390226
RPL34 ribosomal protein L34 -0.0378496
RPL31 ribosomal protein L31 -0.0370177
RPL9 ribosomal protein L9 -0.03643
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0351287
RPL28 ribosomal protein L28 -0.035035
EGR1 early growth response 1 -0.03446
RPL5 ribosomal protein L5 -0.0335409
RPLP2 ribosomal protein, large, P2 -0.0329031
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0327253
S100A10 S100 calcium binding protein A10 -0.0324391
PFN1 profilin 1 -0.0322069
RPS24 ribosomal protein S24 -0.0320269
RACK1 receptor for activated C kinase 1 -0.0314889
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0313575
RPS14 ribosomal protein S14 -0.0302736
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0297359
RBM25 RNA binding motif protein 25 -0.0297276
S100A6 S100 calcium binding protein A6 -0.0295851
MKI67 marker of proliferation Ki-67 -0.0279774
RPL26 ribosomal protein L26 -0.0278389
RPS5 ribosomal protein S5 -0.0275917
RPL8 ribosomal protein L8 -0.0272902
BPTF bromodomain PHD finger transcription factor -0.02724
RPS3 ribosomal protein S3 -0.0264959
MYL12B myosin, light chain 12B, regulatory -0.0260936
RPS29 ribosomal protein S29 -0.0260259
TUBB4B tubulin, beta 4B class IVb -0.0259747
MT1X metallothionein 1X -0.0258402
VDAC1 voltage-dependent anion channel 1 -0.025391
EIF5B eukaryotic translation initiation factor 5B -0.0245518
RPS12 ribosomal protein S12 -0.0243074
RPS13 ribosomal protein S13 -0.0241837
RPL35 ribosomal protein L35 -0.0241661
HMGB1 high mobility group box 1 -0.0237224
RPS21 ribosomal protein S21 -0.0236319
RPS27A ribosomal protein S27a -0.0231557
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0230538
PKM pyruvate kinase, muscle -0.023017
RPL18 ribosomal protein L18 -0.0227615
RPL37A ribosomal protein L37a -0.0227448
CBX3 chromobox homolog 3 -0.0219272
TXNRD1 thioredoxin reductase 1 -0.0217992
SEPTIN7 septin 7 -0.0217539
RPS15 ribosomal protein S15 -0.021717
RPS23 ribosomal protein S23 -0.0215941
DLG1 discs, large homolog 1 (Drosophila) -0.0211205
RPL11 ribosomal protein L11 -0.0210343
RANBP17 RAN binding protein 17 -0.0207163
UQCRB ubiquinol-cytochrome c reductase binding protein -0.020655
FTH1 ferritin, heavy polypeptide 1 -0.0205229
RPL36 ribosomal protein L36 -0.0204496
GNAS GNAS complex locus -0.0204262
RPL38 ribosomal protein L38 -0.0200533
RPS16 ribosomal protein S16 -0.0198134
RAB7A RAB7A, member RAS oncogene family -0.0197968
WWC1 WW and C2 domain containing 1 -0.0197504
GSTP1 glutathione S-transferase pi 1 -0.0196244
RPL30 ribosomal protein L30 -0.019555
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0189329
HMGA1 high mobility group AT-hook 1 -0.0187696
DEK DEK proto-oncogene -0.0184408
LOC102724023 ES1 protein homolog, mitochondrial -0.0184172
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.018399
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0183586
SMC4 structural maintenance of chromosomes 4 -0.0182723
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.018207
EIF1 eukaryotic translation initiation factor 1 -0.0179888
GOLGA4 golgin A4 -0.0174154
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.017212
UBXN4 UBX domain protein 4 -0.017143
RPL7A ribosomal protein L7a -0.0170851
NAP1L1 nucleosome assembly protein 1-like 1 -0.0169314
GCC2 GRIP and coiled-coil domain containing 2 -0.0166233
RPS10 ribosomal protein S10 -0.0165289
GPHN gephyrin -0.0164788
RPS11 ribosomal protein S11 -0.0160792
KIF18B kinesin family member 18B -0.0159823
RPL27A ribosomal protein L27a -0.0159592
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0155859
PKP4 plakophilin 4 -0.0155692
CCND1 cyclin D1 -0.0154024