| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rutin (trihydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Rutin (trihydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.138242 |
| APOB | apolipoprotein B | 0.116301 |
| FNDC3B | fibronectin type III domain containing 3B | 0.105219 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0928084 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0909504 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0849009 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.079887 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0709825 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0698653 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0698001 |
| RPL11 | ribosomal protein L11 | 0.0576693 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0561103 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0556413 |
| PTMA | prothymosin, alpha | 0.0530202 |
| TF | transferrin | 0.0496198 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0478759 |
| RPL35A | ribosomal protein L35a | 0.0468122 |
| RPS12 | ribosomal protein S12 | 0.0467589 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0465471 |
| SDC4 | syndecan 4 | 0.0451804 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0402027 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0397937 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0396774 |
| RPS24 | ribosomal protein S24 | 0.0390463 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0386152 |
| RPL7 | ribosomal protein L7 | 0.0385098 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0377232 |
| AFDN | afadin, adherens junction formation factor | 0.0373229 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0368154 |
| SBF2 | SET binding factor 2 | 0.0367906 |
| FN1 | fibronectin 1 | 0.0361301 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0355948 |
| RPLP2 | ribosomal protein, large, P2 | 0.0354266 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0352849 |
| RPL26 | ribosomal protein L26 | 0.0346181 |
| APOA2 | apolipoprotein A-II | 0.0343513 |
| RANBP9 | RAN binding protein 9 | 0.0341059 |
| RPS23 | ribosomal protein S23 | 0.033925 |
| RPL19 | ribosomal protein L19 | 0.0337566 |
| CFB | complement factor B | 0.0334282 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0329023 |
| TRIM26 | tripartite motif containing 26 | 0.032818 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0327841 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0327102 |
| TOP1 | topoisomerase (DNA) I | 0.0326729 |
| MT2A | metallothionein 2A | 0.0325664 |
| SPAG9 | sperm associated antigen 9 | 0.0323987 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0321125 |
| RPS27A | ribosomal protein S27a | 0.0317909 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0315436 |
| TMSB10 | thymosin beta 10 | 0.0308979 |
| RPS25 | ribosomal protein S25 | 0.0307643 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0303698 |
| RPL37A | ribosomal protein L37a | 0.0303631 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0299551 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0294654 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0294635 |
| PDZD8 | PDZ domain containing 8 | 0.0294177 |
| DTNA | dystrobrevin, alpha | 0.0291284 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0286777 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0286132 |
| RPL4 | ribosomal protein L4 | 0.0283932 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0281084 |
| YTHDC1 | YTH domain containing 1 | 0.027856 |
| JAK1 | Janus kinase 1 | 0.0278306 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0278091 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0278053 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0277285 |
| RPS6 | ribosomal protein S6 | 0.0271529 |
| RPL9 | ribosomal protein L9 | 0.0268809 |
| ZNF292 | zinc finger protein 292 | 0.0263376 |
| CTSB | cathepsin B | 0.0260887 |
| FAT1 | FAT atypical cadherin 1 | 0.0257748 |
| ENO1 | enolase 1, (alpha) | 0.0257005 |
| RPS29 | ribosomal protein S29 | 0.0253626 |
| RPL36A | ribosomal protein L36a | 0.0252952 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0250452 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0250443 |
| RAB1A | RAB1A, member RAS oncogene family | 0.024927 |
| RPLP1 | ribosomal protein, large, P1 | 0.0249119 |
| RPS14 | ribosomal protein S14 | 0.0248979 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0247771 |
| GPC3 | glypican 3 | 0.0247392 |
| ARRDC3 | arrestin domain containing 3 | 0.024721 |
| MCL1 | myeloid cell leukemia 1 | 0.0245846 |
| RPL5 | ribosomal protein L5 | 0.0245722 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0244972 |
| RPL34 | ribosomal protein L34 | 0.0244855 |
| PLEC | plectin | 0.0244607 |
| RPS8 | ribosomal protein S8 | 0.0244446 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0242264 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0241279 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0241056 |
| RPL31 | ribosomal protein L31 | 0.0240767 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0238482 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0237696 |
| FTL | ferritin, light polypeptide | 0.0236064 |
| PTK2 | protein tyrosine kinase 2 | 0.0234778 |
| A2M | alpha-2-macroglobulin | 0.0234082 |
| RPL12 | ribosomal protein L12 | 0.0232589 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.442067 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.143687 |
| EHBP1 | EH domain binding protein 1 | -0.127487 |
| GPC6 | glypican 6 | -0.111202 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.110645 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0868651 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0817024 |
| C3 | complement component 3 | -0.0700883 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0696403 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0673827 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0652296 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0567369 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0497615 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0495569 |
| FRMD5 | FERM domain containing 5 | -0.0448874 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0438531 |
| ATXN1 | ataxin 1 | -0.0437264 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0435284 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0417741 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0412162 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0403402 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0391621 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0389015 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0380102 |
| RUNX1 | runt-related transcription factor 1 | -0.0366274 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0360189 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0349977 |
| ITGA1 | integrin, alpha 1 | -0.0344456 |
| PTCHD4 | patched domain containing 4 | -0.0343998 |
| DST | dystonin | -0.0337645 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0325716 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0325368 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.031524 |
| KIZ | kizuna centrosomal protein | -0.0306856 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0299312 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.029573 |
| PLIN2 | perilipin 2 | -0.0293883 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0292501 |
| FOXP1 | forkhead box P1 | -0.0287846 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0280745 |
| VMP1 | vacuole membrane protein 1 | -0.0275148 |
| FILIP1L | filamin A interacting protein 1-like | -0.0267354 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0259299 |
| NABP1 | nucleic acid binding protein 1 | -0.025854 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.02573 |
| MALT1 | MALT1 paracaspase | -0.0256548 |
| FAM135A | family with sequence similarity 135, member A | -0.0256123 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0252955 |
| STK17A | serine/threonine kinase 17a | -0.0251279 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0247287 |
| TMEM123 | transmembrane protein 123 | -0.0239346 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0237263 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0236597 |
| PDLIM5 | PDZ and LIM domain 5 | -0.023599 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0234393 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0231127 |
| RNASET2 | ribonuclease T2 | -0.0231053 |
| GK | glycerol kinase | -0.0230694 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0225291 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0223285 |
| CDK6 | cyclin-dependent kinase 6 | -0.0220345 |
| ZNF638 | zinc finger protein 638 | -0.0216428 |
| PRKCA | protein kinase C, alpha | -0.0213916 |
| DISC1 | disrupted in schizophrenia 1 | -0.0212611 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0208291 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0206198 |
| ASPH | aspartate beta-hydroxylase | -0.0203446 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0202418 |
| GLIS3 | GLIS family zinc finger 3 | -0.0202142 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0201931 |
| TNS3 | tensin 3 | -0.0201173 |
| FKTN | fukutin | -0.019563 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0193781 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0191392 |
| HDAC4 | histone deacetylase 4 | -0.0191246 |
| PLXDC2 | plexin domain containing 2 | -0.0189498 |
| UTRN | utrophin | -0.0185108 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0181592 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0181391 |
| RAD51B | RAD51 paralog B | -0.0178347 |
| TMEM45B | transmembrane protein 45B | -0.01715 |
| PEG10 | paternally expressed 10 | -0.0171457 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0168395 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0167821 |
| CCN2 | cellular communication network factor 2 | -0.0165448 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0165017 |
| TOX3 | TOX high mobility group box family member 3 | -0.0164939 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0163161 |
| LOX | lysyl oxidase | -0.0162699 |
| CP | ceruloplasmin (ferroxidase) | -0.0160903 |
| CNKSR3 | CNKSR family member 3 | -0.016036 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0158733 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0155781 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0155665 |
| MYO1E | myosin IE | -0.0155514 |
| PERP | PERP, TP53 apoptosis effector | -0.0155377 |
| PKP4 | plakophilin 4 | -0.0154505 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0153434 |
| MPZL2 | myelin protein zero-like 2 | -0.0151261 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.015122 |
