Rutin (trihydrate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.130868
PLEC plectin 0.123017
MYH9 myosin, heavy chain 9, non-muscle 0.107031
MYOF myoferlin 0.0927577
CEMIP cell migration inducing protein, hyaluronan binding 0.0843951
MTSS1 metastasis suppressor 1 0.0822247
TRIO trio Rho guanine nucleotide exchange factor 0.0786359
SMAD3 SMAD family member 3 0.0771073
MEF2A myocyte enhancer factor 2A 0.0697635
KIAA1217 KIAA1217 0.0634283
MACF1 microtubule-actin crosslinking factor 1 0.0631696
MSN moesin 0.0595999
FOXO1 forkhead box O1 0.0537309
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0531194
GRB10 growth factor receptor-bound protein 10 0.0522412
FLNA filamin A, alpha 0.0485244
BHLHE40 basic helix-loop-helix family, member e40 0.0478815
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.045659
KDM6A lysine (K)-specific demethylase 6A 0.0451053
OGA O-GlcNAcase 0.0444746
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0444018
FNDC3B fibronectin type III domain containing 3B 0.0441043
ACTN4 actinin, alpha 4 0.0438251
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0437523
AHNAK AHNAK nucleoprotein 0.0433672
NAMPT nicotinamide phosphoribosyltransferase 0.0429624
ANKRD33B ankyrin repeat domain 33B 0.0426944
PDLIM1 PDZ and LIM domain 1 0.042581
RICTOR RPTOR independent companion of MTOR, complex 2 0.0416918
PTK2 protein tyrosine kinase 2 0.0412663
CTNND1 catenin (cadherin-associated protein), delta 1 0.0397178
PRELID2 PRELI domain containing 2 0.0396166
ESYT2 extended synaptotagmin-like protein 2 0.0394649
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0394102
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0385688
NAV2 neuron navigator 2 0.0381627
MYO10 myosin X 0.037886
DOCK5 dedicator of cytokinesis 5 0.0367758
NEK7 NIMA-related kinase 7 0.0365109
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0353469
SLC45A4 solute carrier family 45, member 4 0.0352405
RIN2 Ras and Rab interactor 2 0.0347105
BCL2L1 BCL2-like 1 0.0344307
SBF2 SET binding factor 2 0.0341779
ASPH aspartate beta-hydroxylase 0.0341393
CUL4B cullin 4B 0.034101
ANLN anillin, actin binding protein 0.0339585
SEPTIN9 septin 9 0.0325635
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0325229
CD44 CD44 molecule (Indian blood group) 0.0323454
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0320566
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0319224
NCOR2 nuclear receptor corepressor 2 0.0310083
MEGF6 multiple EGF-like-domains 6 0.0308587
LOXL2 lysyl oxidase-like 2 0.0306579
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0305482
AFAP1 actin filament associated protein 1 0.0302065
VCL vinculin 0.0300954
PTPRJ protein tyrosine phosphatase, receptor type, J 0.030081
ZNF292 zinc finger protein 292 0.0300725
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0299504
MCL1 myeloid cell leukemia 1 0.0298339
AOPEP aminopeptidase O (putative) 0.0297775
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.029763
ARGLU1 arginine and glutamate rich 1 0.0296227
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0295862
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0289013
NCOA3 nuclear receptor coactivator 3 0.0288224
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0283791
PLAT plasminogen activator, tissue 0.0276849
BCAR3 breast cancer anti-estrogen resistance 3 0.0275647
MARCHF6 membrane associated ring-CH-type finger 6 0.0268332
ARRDC3 arrestin domain containing 3 0.0266913
NRIP1 nuclear receptor interacting protein 1 0.0266066
SOX13 SRY (sex determining region Y)-box 13 0.0265155
EXT1 exostosin glycosyltransferase 1 0.0262061
SH3PXD2A SH3 and PX domains 2A 0.0260208
TNIP1 TNFAIP3 interacting protein 1 0.0257855
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0253787
LIFR leukemia inhibitory factor receptor alpha 0.0253783
H1-0 H1.0 linker histone 0.0252183
SPAG9 sperm associated antigen 9 0.0251418
ARHGAP21 Rho GTPase activating protein 21 0.0251261
KMT2E lysine (K)-specific methyltransferase 2E 0.0251168
FOXP1 forkhead box P1 0.0250925
BLCAP bladder cancer associated protein 0.0246331
TGM2 transglutaminase 2 0.0246185
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0244339
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0243157
APLP2 amyloid beta (A4) precursor-like protein 2 0.0242359
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0239743
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0238284
KDM3A lysine (K)-specific demethylase 3A 0.0233235
RBM39 RNA binding motif protein 39 0.0232376
DIDO1 death inducer-obliterator 1 0.0232102
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0230468
MED13L mediator complex subunit 13-like 0.022956
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0229338
CAPRIN2 caprin family member 2 0.02282
ANXA11 annexin A11 0.0227594

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.146519
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.100255
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0958658
PTMA prothymosin, alpha -0.070563
MT2A metallothionein 2A -0.0690505
RPS6 ribosomal protein S6 -0.0614469
TMSB10 thymosin beta 10 -0.0605558
B2M beta-2-microglobulin -0.0599252
HLA-B major histocompatibility complex, class I, B -0.0518615
RPS8 ribosomal protein S8 -0.047854
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0465447
TPT1 tumor protein, translationally-controlled 1 -0.0462142
RPLP2 ribosomal protein, large, P2 -0.0453478
RPLP1 ribosomal protein, large, P1 -0.0446034
S100A10 S100 calcium binding protein A10 -0.0418771
RPS13 ribosomal protein S13 -0.0415583
IGF2 insulin-like growth factor 2 -0.0409862
RPS3 ribosomal protein S3 -0.0406024
FTL ferritin, light polypeptide -0.0405178
RPS21 ribosomal protein S21 -0.0404668
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0379697
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0361663
RPL37 ribosomal protein L37 -0.0360479
ZMYND8 zinc finger, MYND-type containing 8 -0.0357554
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0355619
RPS19 ribosomal protein S19 -0.0355117
LDHA lactate dehydrogenase A -0.034822
INTS6 integrator complex subunit 6 -0.0338409
RPL35A ribosomal protein L35a -0.0331154
S100A11 S100 calcium binding protein A11 -0.033059
IFITM3 interferon induced transmembrane protein 3 -0.0322793
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0320435
ALCAM activated leukocyte cell adhesion molecule -0.0318838
DPYD dihydropyrimidine dehydrogenase -0.030575
PDLIM5 PDZ and LIM domain 5 -0.0305329
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0299897
S100A9 S100 calcium binding protein A9 -0.0299402
GNAS GNAS complex locus -0.0298617
RPL37A ribosomal protein L37a -0.0295212
HM13 histocompatibility (minor) 13 -0.0292463
RPL8 ribosomal protein L8 -0.0291633
S100A6 S100 calcium binding protein A6 -0.0288306
RPL34 ribosomal protein L34 -0.0280549
CAV1 caveolin 1, caveolae protein, 22kDa -0.0278877
RPS25 ribosomal protein S25 -0.0278367
IFITM1 interferon induced transmembrane protein 1 -0.0273726
CSTB cystatin B (stefin B) -0.0267093
EGR1 early growth response 1 -0.0267062
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0260248
RPL12 ribosomal protein L12 -0.026
POTEF POTE ankyrin domain family, member F -0.0255177
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.025212
RACK1 receptor for activated C kinase 1 -0.0243319
VDAC1 voltage-dependent anion channel 1 -0.0240407
WASF2 WAS protein family, member 2 -0.023866
PFN1 profilin 1 -0.0236697
SQLE squalene epoxidase -0.0235672
ACTG1 actin gamma 1 -0.0235488
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0231592
RPL7A ribosomal protein L7a -0.0231115
RPL9 ribosomal protein L9 -0.0230503
S100A2 S100 calcium binding protein A2 -0.0229951
MTDH metadherin -0.0227321
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0227124
RPS24 ribosomal protein S24 -0.0226468
CNRIP1 cannabinoid receptor interacting protein 1 -0.0224005
RPL11 ribosomal protein L11 -0.0221891
ANXA1 annexin A1 -0.0220477
RPS29 ribosomal protein S29 -0.0219734
MT1X metallothionein 1X -0.0215284
RPS14 ribosomal protein S14 -0.0215013
EIF1 eukaryotic translation initiation factor 1 -0.0207857
RPS12 ribosomal protein S12 -0.0207738
ENO2 enolase 2 (gamma, neuronal) -0.0205728
THBD thrombomodulin -0.0205197
RPS27A ribosomal protein S27a -0.0201378
RPL26 ribosomal protein L26 -0.0199688
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0199615
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0199116
RPL27A ribosomal protein L27a -0.0197786
ABI3BP ABI family, member 3 (NESH) binding protein -0.0196759
RPL31 ribosomal protein L31 -0.0196586
RPL23 ribosomal protein L23 -0.0195812
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0193949
SRRM2 serine/arginine repetitive matrix 2 -0.0191826
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0186819
MDK midkine (neurite growth-promoting factor 2) -0.0186618
IFI27 interferon, alpha-inducible protein 27 -0.0185183
RPL28 ribosomal protein L28 -0.0183484
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0182627
MYADM myeloid-associated differentiation marker -0.018169
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0181205
MORF4L2 mortality factor 4 like 2 -0.018056
FSCN1 fascin actin-bundling protein 1 -0.0179446
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0179037
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.017893
MT1E metallothionein 1E -0.0178453
KISS1 KiSS-1 metastasis-suppressor -0.0177529
CAV2 caveolin 2 -0.0176108
CYB5R3 cytochrome b5 reductase 3 -0.0175834