Rutin (trihydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0741941
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0547001
MYH9 myosin, heavy chain 9, non-muscle 0.0545252
CD109 CD109 molecule 0.0531139
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0521835
LSAMP limbic system-associated membrane protein 0.0500877
MCL1 myeloid cell leukemia 1 0.0449618
FLNA filamin A, alpha 0.0438722
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0437283
CORO1C coronin, actin binding protein, 1C 0.0424171
FN1 fibronectin 1 0.0409777
NUP58 nucleoporin 58 0.0400618
UBA6 ubiquitin-like modifier activating enzyme 6 0.0391464
ELL2 elongation factor, RNA polymerase II, 2 0.0390889
CXCL8 chemokine (C-X-C motif) ligand 8 0.035793
VEZT vezatin, adherens junctions transmembrane protein 0.0340011
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0301837
AKAP12 A kinase (PRKA) anchor protein 12 0.0301165
SPAG9 sperm associated antigen 9 0.0297756
MSN moesin 0.0295009
ADAM9 ADAM metallopeptidase domain 9 0.0288103
HSPA8 heat shock 70kDa protein 8 0.0287962
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0279464
RNF145 ring finger protein 145 0.0275589
OGA O-GlcNAcase 0.0275519
DDIT4 DNA-damage-inducible transcript 4 0.0275128
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0273819
ARRDC3 arrestin domain containing 3 0.0265711
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0262012
EEF2 eukaryotic translation elongation factor 2 0.02595
MALT1 MALT1 paracaspase 0.0257593
CASC3 cancer susceptibility candidate 3 0.0256609
ARGLU1 arginine and glutamate rich 1 0.0254481
EIF4B eukaryotic translation initiation factor 4B 0.0241028
ANXA2 annexin A2 0.023816
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0235954
TAC4 tachykinin 4 (hemokinin) 0.0235652
CCNL1 cyclin L1 0.0235456
HOOK2 hook microtubule-tethering protein 2 0.0233368
HILPDA hypoxia inducible lipid droplet-associated 0.0228871
FGFR1 fibroblast growth factor receptor 1 0.0221858
EGLN1 egl-9 family hypoxia-inducible factor 1 0.022138
KLF6 Kruppel-like factor 6 0.0220804
PLEC plectin 0.0217445
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0217042
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0208297
ADM adrenomedullin 0.0208252
MMP12 matrix metallopeptidase 12 0.0207883
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0206217
ABI1 abl-interactor 1 0.0203625
HELZ helicase with zinc finger 0.0201838
RTTN rotatin 0.020092
DST dystonin 0.0200299
RIMKLB ribosomal modification protein rimK-like family member B 0.019886
MAP2K1 mitogen-activated protein kinase kinase 1 0.0195349
YTHDC1 YTH domain containing 1 0.0194568
TPM3 tropomyosin 3 0.019227
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0191357
SETD5 SET domain containing 5 0.0191192
KDM3A lysine (K)-specific demethylase 3A 0.0190956
COLEC11 collectin sub-family member 11 0.0190529
MIDEAS mitotic deacetylase associated SANT domain protein 0.0188169
PFKP phosphofructokinase, platelet 0.0187908
APLP2 amyloid beta (A4) precursor-like protein 2 0.0186877
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0183033
RAB8B RAB8B, member RAS oncogene family 0.018221
RPL19 ribosomal protein L19 0.0182203
UGCG UDP-glucose ceramide glucosyltransferase 0.0181903
ENO2 enolase 2 (gamma, neuronal) 0.0180899
WDR45B WD repeat domain 45B 0.0180311
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.017766
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0174262
ZMYM2 zinc finger, MYM-type 2 0.0173575
MYO10 myosin X 0.01732
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0170317
PCBP2 poly(rC) binding protein 2 0.0164894
MYO1B myosin IB 0.0163792
RARB retinoic acid receptor, beta 0.016174
CHD1L chromodomain helicase DNA binding protein 1-like 0.0161563
ACTN4 actinin, alpha 4 0.015609
ESYT2 extended synaptotagmin-like protein 2 0.015542
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0153512
SPAG5 sperm associated antigen 5 0.0153252
ANXA1 annexin A1 0.0153197
CTNND1 catenin (cadherin-associated protein), delta 1 0.015284
RAD23B RAD23 homolog B (S. cerevisiae) 0.0152158
ACVR1 activin A receptor, type I 0.0151822
MB21D2 Mab-21 domain containing 2 0.0150839
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0149332
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0149311
ARHGAP21 Rho GTPase activating protein 21 0.0149139
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0149003
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0147563
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.014599
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0145625
EEF1G eukaryotic translation elongation factor 1 gamma 0.0143003
RPL3 ribosomal protein L3 0.0141295
ARID1A AT rich interactive domain 1A (SWI-like) 0.0141254
SECISBP2L SECIS binding protein 2-like 0.0140451
RAB6A RAB6A, member RAS oncogene family 0.0140408

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.404074
ACTG1 actin gamma 1 -0.153808
RPS6 ribosomal protein S6 -0.148027
EFNA5 ephrin-A5 -0.0977688
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0958902
PRKG1 protein kinase, cGMP-dependent, type I -0.092471
TPT1 tumor protein, translationally-controlled 1 -0.0833761
SAMD3 sterile alpha motif domain containing 3 -0.0749534
FTL ferritin, light polypeptide -0.0745606
AHNAK AHNAK nucleoprotein -0.0717338
ALCAM activated leukocyte cell adhesion molecule -0.067558
ASPH aspartate beta-hydroxylase -0.066483
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0609335
CALD1 caldesmon 1 -0.0583199
RPL23 ribosomal protein L23 -0.0570655
RPS8 ribosomal protein S8 -0.0567824
DPYD dihydropyrimidine dehydrogenase -0.0557047
RPLP1 ribosomal protein, large, P1 -0.0546251
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0545919
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0541289
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0532516
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.053005
NAP1L1 nucleosome assembly protein 1-like 1 -0.0521055
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.049846
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0495876
SDCCAG8 serologically defined colon cancer antigen 8 -0.049325
BPTF bromodomain PHD finger transcription factor -0.0490588
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0486148
PTPRG protein tyrosine phosphatase, receptor type, G -0.0479454
GPHN gephyrin -0.0472642
NF1 neurofibromin 1 -0.0468708
SAMD4A sterile alpha motif domain containing 4A -0.0461901
RPL35A ribosomal protein L35a -0.0460229
INTS6 integrator complex subunit 6 -0.0450485
FOXP1 forkhead box P1 -0.0447505
RPS13 ribosomal protein S13 -0.0443116
MBD5 methyl-CpG binding domain protein 5 -0.0438201
MCTP1 multiple C2 domains, transmembrane 1 -0.0433785
LDHA lactate dehydrogenase A -0.0427433
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0425733
PTCHD4 patched domain containing 4 -0.0422797
RPL12 ribosomal protein L12 -0.0412584
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0411431
RPS3 ribosomal protein S3 -0.0399598
USP34 ubiquitin specific peptidase 34 -0.0398801
RPS24 ribosomal protein S24 -0.0394875
RUNX1 runt-related transcription factor 1 -0.0391555
RPL8 ribosomal protein L8 -0.03852
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0384196
MT2A metallothionein 2A -0.0383311
TXNRD1 thioredoxin reductase 1 -0.0382462
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0375572
RPLP2 ribosomal protein, large, P2 -0.0375051
PTPRD protein tyrosine phosphatase, receptor type, D -0.0373594
TMPRSS15 transmembrane protease, serine 15 -0.0371268
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0369734
RPS21 ribosomal protein S21 -0.0360675
RTN4 reticulon 4 -0.0359051
KTN1 kinectin 1 (kinesin receptor) -0.0355328
KYNU kynureninase -0.0350247
HMGA2 high mobility group AT-hook 2 -0.0349529
KIAA1217 KIAA1217 -0.0349289
MYO9A myosin IXA -0.0348197
TMSB10 thymosin beta 10 -0.0347981
RPL32 ribosomal protein L32 -0.0345258
CDH13 cadherin 13 -0.0341001
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0340372
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0339568
RPS27A ribosomal protein S27a -0.0339176
DOCK4 dedicator of cytokinesis 4 -0.0338378
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0334576
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0334545
PTMA prothymosin, alpha -0.0333861
RPLP0 ribosomal protein, large, P0 -0.0333311
RPL11 ribosomal protein L11 -0.0332851
RPL26 ribosomal protein L26 -0.033242
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0328846
PARD3 par-3 family cell polarity regulator -0.0327915
NALF1 NALCN channel auxiliary factor 1 -0.0326789
RPL34 ribosomal protein L34 -0.0326635
SP100 SP100 nuclear antigen -0.0325842
ZBTB20 zinc finger and BTB domain containing 20 -0.032215
RPS2 ribosomal protein S2 -0.0322099
RPL31 ribosomal protein L31 -0.0320839
RPL38 ribosomal protein L38 -0.031558
TAS2R14 taste receptor, type 2, member 14 -0.0315265
RPS19 ribosomal protein S19 -0.0310356
EGR1 early growth response 1 -0.0310256
ERBIN erbb2 interacting protein -0.0309593
CD44 CD44 molecule (Indian blood group) -0.0308353
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0307434
ANKRD28 ankyrin repeat domain 28 -0.0305805
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0304617
OSBPL8 oxysterol binding protein-like 8 -0.0302067
ZFAND3 zinc finger, AN1-type domain 3 -0.0301619
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0300858
PDE4D phosphodiesterase 4D, cAMP-specific -0.0299885
RPL28 ribosomal protein L28 -0.0299742
SON SON DNA binding protein -0.029964
EIF1 eukaryotic translation initiation factor 1 -0.0297311