Rutin (trihydrate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.150007
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0923219
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0851304
EZR ezrin 0.0791874
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0788805
SPAG9 sperm associated antigen 9 0.0723497
MACF1 microtubule-actin crosslinking factor 1 0.0685879
TMSB4X thymosin beta 4, X-linked 0.0647052
DST dystonin 0.0639988
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0631331
MYH9 myosin, heavy chain 9, non-muscle 0.0618959
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0602139
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0483274
SLC38A2 solute carrier family 38, member 2 0.0478797
LOXL2 lysyl oxidase-like 2 0.0476151
OGA O-GlcNAcase 0.0473797
AHNAK AHNAK nucleoprotein 0.0467796
CAPRIN2 caprin family member 2 0.0459658
EEF2 eukaryotic translation elongation factor 2 0.0447995
APP amyloid beta (A4) precursor protein 0.0440059
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0429734
FLNB filamin B, beta 0.0425398
HOOK2 hook microtubule-tethering protein 2 0.0415786
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0415186
ANKRD11 ankyrin repeat domain 11 0.040708
XPO1 exportin 1 0.0403761
TXNRD1 thioredoxin reductase 1 0.0391142
CANX calnexin 0.0390791
RAI1 retinoic acid induced 1 0.0370705
ADAM17 ADAM metallopeptidase domain 17 0.0369456
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0369075
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0364055
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.036374
CENPF centromere protein F, 350/400kDa 0.0358739
DSCAM Down syndrome cell adhesion molecule 0.0352395
YEATS2 YEATS domain containing 2 0.0348138
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0347744
CSNK1A1 casein kinase 1, alpha 1 0.0343107
TRIO trio Rho guanine nucleotide exchange factor 0.0336402
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0326305
SMAD3 SMAD family member 3 0.0322995
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0322022
TRIP12 thyroid hormone receptor interactor 12 0.0319196
PLEC plectin 0.0315726
RTN4 reticulon 4 0.0309561
KDM3A lysine (K)-specific demethylase 3A 0.0308918
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0303296
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0302459
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0301115
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0299995
PYGL phosphorylase, glycogen, liver 0.0299431
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0297145
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0295968
SBF2 SET binding factor 2 0.0293944
PGK1 phosphoglycerate kinase 1 0.0293803
MCL1 myeloid cell leukemia 1 0.0289334
ATP13A3 ATPase type 13A3 0.0288029
SFPQ splicing factor proline/glutamine-rich 0.0282998
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0280619
HSPA8 heat shock 70kDa protein 8 0.0279798
MSN moesin 0.0278459
HDLBP high density lipoprotein binding protein 0.027636
FMNL2 formin-like 2 0.0274805
USP9X ubiquitin specific peptidase 9, X-linked 0.0271027
ESYT2 extended synaptotagmin-like protein 2 0.027061
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0269928
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0269477
CSDE1 cold shock domain containing E1, RNA-binding 0.0268551
ANXA1 annexin A1 0.0264414
TPM3 tropomyosin 3 0.0260832
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0260113
IQGAP1 IQ motif containing GTPase activating protein 1 0.0258445
CKAP5 cytoskeleton associated protein 5 0.0257342
PRPF8 pre-mRNA processing factor 8 0.0255191
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0254491
KMT2C lysine (K)-specific methyltransferase 2C 0.0251592
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0250385
DOCK11 dedicator of cytokinesis 11 0.024987
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0249863
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0249356
CAMTA1 calmodulin binding transcription activator 1 0.0246049
PYGB phosphorylase, glycogen; brain 0.0244864
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0243848
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0243445
ETNK1 ethanolamine kinase 1 0.0242411
ANLN anillin, actin binding protein 0.0240817
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0240427
ZNF292 zinc finger protein 292 0.0240267
PUM2 pumilio RNA-binding family member 2 0.0239212
ARRDC3 arrestin domain containing 3 0.0238568
RBM39 RNA binding motif protein 39 0.0238459
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0238123
AFF4 AF4/FMR2 family, member 4 0.0235605
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0233777
DENND5A DENN/MADD domain containing 5A 0.0229688
KLF6 Kruppel-like factor 6 0.0227496
ADAR adenosine deaminase, RNA-specific 0.0226996
BIRC6 baculoviral IAP repeat containing 6 0.0226328
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0225749
PCBP2 poly(rC) binding protein 2 0.0225038

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.289788
MT2A metallothionein 2A -0.249222
TP63 tumor protein p63 -0.121056
TMSB10 thymosin beta 10 -0.120183
FTL ferritin, light polypeptide -0.114107
VIM vimentin -0.0909269
HLA-B major histocompatibility complex, class I, B -0.0745692
POTEF POTE ankyrin domain family, member F -0.0676647
RPL35A ribosomal protein L35a -0.0674689
RPS6 ribosomal protein S6 -0.0656732
MT1E metallothionein 1E -0.0617123
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0608532
RPS8 ribosomal protein S8 -0.0602492
PTMA prothymosin, alpha -0.058788
RPS19 ribosomal protein S19 -0.0570074
ACTG1 actin gamma 1 -0.0524491
MT1X metallothionein 1X -0.0523537
CADM2 cell adhesion molecule 2 -0.0504041
CD44 CD44 molecule (Indian blood group) -0.049959
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0493478
EGR1 early growth response 1 -0.0471313
RPL12 ribosomal protein L12 -0.0466945
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0458439
RPL31 ribosomal protein L31 -0.0440099
RPLP2 ribosomal protein, large, P2 -0.0421019
RPLP1 ribosomal protein, large, P1 -0.0409496
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0391464
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0388036
RPL37A ribosomal protein L37a -0.0387296
TPT1 tumor protein, translationally-controlled 1 -0.0379349
RPL36 ribosomal protein L36 -0.0378732
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0360566
RPL28 ribosomal protein L28 -0.0330542
SP100 SP100 nuclear antigen -0.03282
DPYD dihydropyrimidine dehydrogenase -0.0319935
RIGI RNA sensor RIG-I -0.0318499
SRGN serglycin -0.0309009
B2M beta-2-microglobulin -0.0299065
IFITM1 interferon induced transmembrane protein 1 -0.0295163
KTN1 kinectin 1 (kinesin receptor) -0.0285376
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.028319
S100A9 S100 calcium binding protein A9 -0.0282139
RPL34 ribosomal protein L34 -0.028048
MCTP1 multiple C2 domains, transmembrane 1 -0.0279729
RPS3 ribosomal protein S3 -0.0278416
RACK1 receptor for activated C kinase 1 -0.0275453
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0273246
IFI6 interferon, alpha-inducible protein 6 -0.0271812
RPL23 ribosomal protein L23 -0.0267575
RPL8 ribosomal protein L8 -0.0265771
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.026175
RPS29 ribosomal protein S29 -0.0259955
RAB7A RAB7A, member RAS oncogene family -0.0256483
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0256076
RPL26 ribosomal protein L26 -0.0253963
RPS24 ribosomal protein S24 -0.0251704
RPS13 ribosomal protein S13 -0.0250507
RPS21 ribosomal protein S21 -0.0239844
RPS15 ribosomal protein S15 -0.0235484
INTS6 integrator complex subunit 6 -0.0233599
RPS12 ribosomal protein S12 -0.0230428
RPL38 ribosomal protein L38 -0.022991
RPS10 ribosomal protein S10 -0.0229105
LOC102724023 ES1 protein homolog, mitochondrial -0.0227633
RPS14 ribosomal protein S14 -0.0225395
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0223958
RPL18 ribosomal protein L18 -0.0223743
HMGA1 high mobility group AT-hook 1 -0.022322
PFN1 profilin 1 -0.0222599
RPL37 ribosomal protein L37 -0.0222264
HLA-A major histocompatibility complex, class I, A -0.0219862
IFIH1 interferon induced with helicase C domain 1 -0.0218297
RPL36A ribosomal protein L36a -0.021319
PDE10A phosphodiesterase 10A -0.0211377
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0210939
RPL35 ribosomal protein L35 -0.0208563
RPS23 ribosomal protein S23 -0.0208141
RPL5 ribosomal protein L5 -0.0207615
RPL27 ribosomal protein L27 -0.0205907
TRIM56 tripartite motif containing 56 -0.0205879
EPHA4 EPH receptor A4 -0.0205581
PLSCR1 phospholipid scramblase 1 -0.0204963
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0203817
RPLP0 ribosomal protein, large, P0 -0.0201562
RPL11 ribosomal protein L11 -0.0198858
RPS16 ribosomal protein S16 -0.019866
AREG amphiregulin -0.0195252
BPTF bromodomain PHD finger transcription factor -0.0195179
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0195018
CSMD3 CUB and Sushi multiple domains 3 -0.0194973
BICD1 bicaudal D homolog 1 (Drosophila) -0.0193535
RPL7A ribosomal protein L7a -0.0193456
RPL9 ribosomal protein L9 -0.0191327
RUNX1 runt-related transcription factor 1 -0.0191028
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.019071
TNS3 tensin 3 -0.0189401
PMP22 peripheral myelin protein 22 -0.0187896
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0186717
TIMP1 TIMP metallopeptidase inhibitor 1 -0.018574
RPS27 ribosomal protein S27 -0.0185487