Rutin (trihydrate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0899232
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0645125
WDR43 WD repeat domain 43 0.0409827
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0360379
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0356049
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0337941
TPM3 tropomyosin 3 0.0321793
ERRFI1 ERBB receptor feedback inhibitor 1 0.0313728
RBM39 RNA binding motif protein 39 0.0311477
CENPF centromere protein F, 350/400kDa 0.0302135
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0298011
MCL1 myeloid cell leukemia 1 0.0288161
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0265413
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0256711
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0249335
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0241781
RPL7 ribosomal protein L7 0.0238213
HMGA1 high mobility group AT-hook 1 0.0236709
RNF145 ring finger protein 145 0.0234164
RAD51B RAD51 paralog B 0.0230782
RPL19 ribosomal protein L19 0.0229656
EIF3H eukaryotic translation initiation factor 3, subunit H 0.022632
CABIN1 calcineurin binding protein 1 0.0226257
FAM168A family with sequence similarity 168, member A 0.0222233
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0220063
AKAP12 A kinase (PRKA) anchor protein 12 0.0218455
MYH9 myosin, heavy chain 9, non-muscle 0.0215809
TRA2A transformer 2 alpha homolog (Drosophila) 0.0211366
TES testin LIM domain protein 0.0198759
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0198556
PDLIM5 PDZ and LIM domain 5 0.0198284
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0198114
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0197401
RSRC2 arginine/serine-rich coiled-coil 2 0.0196818
MACF1 microtubule-actin crosslinking factor 1 0.0196759
ANXA1 annexin A1 0.0196438
TRIO trio Rho guanine nucleotide exchange factor 0.0194431
YBX1 Y box binding protein 1 0.0192535
NUP58 nucleoporin 58 0.0191369
CCNL1 cyclin L1 0.0190891
RPL3 ribosomal protein L3 0.0187639
PTK2 protein tyrosine kinase 2 0.0184062
USP3 ubiquitin specific peptidase 3 0.0181852
SND1 staphylococcal nuclease and tudor domain containing 1 0.0181462
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0181244
KMT2C lysine (K)-specific methyltransferase 2C 0.0176653
RPS7 ribosomal protein S7 0.017562
BCLAF1 BCL2-associated transcription factor 1 0.0169563
BAG6 BCL2-associated athanogene 6 0.0167486
CSDE1 cold shock domain containing E1, RNA-binding 0.0165873
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0165601
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0164044
FXR1 fragile X mental retardation, autosomal homolog 1 0.0162676
ADAR adenosine deaminase, RNA-specific 0.016255
SPAG5 sperm associated antigen 5 0.016253
WWOX WW domain containing oxidoreductase 0.0161534
HYOU1 hypoxia up-regulated 1 0.0161269
SPAG9 sperm associated antigen 9 0.0158034
AHR aryl hydrocarbon receptor 0.0157302
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.015432
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0154137
NUMA1 nuclear mitotic apparatus protein 1 0.0154134
HELZ helicase with zinc finger 0.015284
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0152044
CRY1 cryptochrome circadian clock 1 0.0151563
KMT2E lysine (K)-specific methyltransferase 2E 0.0149054
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0148948
PCBP2 poly(rC) binding protein 2 0.0148387
HDGF hepatoma-derived growth factor 0.0148269
EEF1G eukaryotic translation elongation factor 1 gamma 0.0147826
CTNNBL1 catenin, beta like 1 0.0147661
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0146813
PNN pinin, desmosome associated protein 0.0146767
ADGRG6 adhesion G protein-coupled receptor G6 0.0146664
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.0145569
LPP LIM domain containing preferred translocation partner in lipoma 0.0144795
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0144775
NUP153 nucleoporin 153kDa 0.0142943
ADAM9 ADAM metallopeptidase domain 9 0.0139892
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0138637
ENAH enabled homolog (Drosophila) 0.0138005
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0137476
APLP2 amyloid beta (A4) precursor-like protein 2 0.0136954
KIF5B kinesin family member 5B 0.0135093
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0134528
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0133959
DCAF5 DDB1 and CUL4 associated factor 5 0.0131296
MBNL1 muscleblind-like splicing regulator 1 0.0131226
PRR16 proline rich 16 0.0129848
PAWR PRKC, apoptosis, WT1, regulator 0.0128338
MLEC malectin 0.012806
MIDEAS mitotic deacetylase associated SANT domain protein 0.012624
ZNF292 zinc finger protein 292 0.0126151
GLS2 glutaminase 2 (liver, mitochondrial) 0.0125109
ANLN anillin, actin binding protein 0.0124994
PRKCE protein kinase C, epsilon 0.0123965
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0123412
MRTFA myocardin related transcription factor A 0.0122631
SPOPL speckle-type POZ protein-like 0.0122549
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0122245

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.389588
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.208434
TMSB10 thymosin beta 10 -0.184466
TM4SF1 transmembrane 4 L six family member 1 -0.0944808
IER3 immediate early response 3 -0.0909963
FTL ferritin, light polypeptide -0.0905546
RPS27A ribosomal protein S27a -0.0877178
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0864463
ACTG1 actin gamma 1 -0.0848158
PTMA prothymosin, alpha -0.0767573
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0755729
RPL23 ribosomal protein L23 -0.074381
UBC ubiquitin C -0.0651036
VIM vimentin -0.0644712
S100A6 S100 calcium binding protein A6 -0.0609637
AHNAK AHNAK nucleoprotein -0.0606658
GRAMD1B GRAM domain containing 1B -0.0533368
IGF2 insulin-like growth factor 2 -0.0527635
THSD4 thrombospondin, type I, domain containing 4 -0.0490152
OSMR oncostatin M receptor -0.0487684
CFLAR CASP8 and FADD-like apoptosis regulator -0.0459453
TPT1 tumor protein, translationally-controlled 1 -0.0438606
SVIL supervillin -0.0427953
C15ORF48 chromosome 15 open reading frame 48 -0.0427387
HLA-B major histocompatibility complex, class I, B -0.042511
FGB fibrinogen beta chain -0.0412661
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0400311
RPS29 ribosomal protein S29 -0.0397371
IGFBP3 insulin-like growth factor binding protein 3 -0.0391363
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0382527
POTEF POTE ankyrin domain family, member F -0.0373552
FAM107B family with sequence similarity 107, member B -0.0362679
RPL8 ribosomal protein L8 -0.0362321
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0356125
S100A10 S100 calcium binding protein A10 -0.0342682
CAVIN1 caveolae associated protein 1 -0.0337921
RPS8 ribosomal protein S8 -0.0336823
RPL31 ribosomal protein L31 -0.0335267
EGFR epidermal growth factor receptor -0.0332188
RPS6 ribosomal protein S6 -0.0323621
PYGL phosphorylase, glycogen, liver -0.0317222
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0315542
LOC102724023 ES1 protein homolog, mitochondrial -0.0311154
RPS21 ribosomal protein S21 -0.0300445
NUMB numb homolog (Drosophila) -0.0294044
EIF1 eukaryotic translation initiation factor 1 -0.0288846
BASP1 brain abundant, membrane attached signal protein 1 -0.0285475
ASPH aspartate beta-hydroxylase -0.0285405
RPLP1 ribosomal protein, large, P1 -0.0284273
SAMD4A sterile alpha motif domain containing 4A -0.0280909
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0273544
RPS19 ribosomal protein S19 -0.0264497
MT1X metallothionein 1X -0.0254377
CD99 CD99 molecule -0.0254058
JMJD1C jumonji domain containing 1C -0.0253398
ZMYND8 zinc finger, MYND-type containing 8 -0.0253032
NTN4 netrin 4 -0.0252397
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0251162
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0250179
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.02435
ENO1 enolase 1, (alpha) -0.0241532
ARHGAP26 Rho GTPase activating protein 26 -0.0237982
RPS15 ribosomal protein S15 -0.0234555
EEF2 eukaryotic translation elongation factor 2 -0.0233024
IL6 interleukin 6 -0.0230616
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0228522
ZFHX3 zinc finger homeobox 3 -0.0228466
RPL36 ribosomal protein L36 -0.0227665
NAV3 neuron navigator 3 -0.0226329
FUS FUS RNA binding protein -0.0224623
ZBTB20 zinc finger and BTB domain containing 20 -0.0224616
GNAS GNAS complex locus -0.0220748
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0220392
GLG1 golgi glycoprotein 1 -0.022017
CFDP1 craniofacial development protein 1 -0.0214736
SRGN serglycin -0.0212591
CDK12 cyclin-dependent kinase 12 -0.0212318
RPL28 ribosomal protein L28 -0.021097
CXCL8 chemokine (C-X-C motif) ligand 8 -0.02099
RPL35A ribosomal protein L35a -0.020953
HLA-E major histocompatibility complex, class I, E -0.0209115
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0205273
CALU calumenin -0.0204362
S100A11 S100 calcium binding protein A11 -0.0203045
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0201618
BICC1 BicC family RNA binding protein 1 -0.0201495
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0200546
S100A9 S100 calcium binding protein A9 -0.0200166
RPL34 ribosomal protein L34 -0.0200021
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0199831
IGFBP4 insulin-like growth factor binding protein 4 -0.0199464
TBCA tubulin folding cofactor A -0.0199291
RPS3 ribosomal protein S3 -0.0197925
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0196309
RBM25 RNA binding motif protein 25 -0.0196283
RPL36AL ribosomal protein L36a-like -0.0196227
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0193974
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0192365
TPM4 tropomyosin 4 -0.0191497
KYNU kynureninase -0.0191027