Rutin (trihydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.27683
MYH9 myosin, heavy chain 9, non-muscle 0.118078
FNDC3B fibronectin type III domain containing 3B 0.116464
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.10605
GRB10 growth factor receptor-bound protein 10 0.0882996
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0834585
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0748007
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0720899
ASPH aspartate beta-hydroxylase 0.0698086
TRIO trio Rho guanine nucleotide exchange factor 0.0639874
PLEC plectin 0.0635697
FAM13A family with sequence similarity 13, member A 0.0612651
NAMPT nicotinamide phosphoribosyltransferase 0.0599641
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0597702
TSC22D2 TSC22 domain family, member 2 0.058295
APLP2 amyloid beta (A4) precursor-like protein 2 0.0524181
ELL2 elongation factor, RNA polymerase II, 2 0.0500913
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0488314
ERRFI1 ERBB receptor feedback inhibitor 1 0.0478722
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0446653
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0444168
SPTBN1 spectrin, beta, non-erythrocytic 1 0.044395
CANX calnexin 0.0436977
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0434669
PTK2 protein tyrosine kinase 2 0.042886
DSPP dentin sialophosphoprotein 0.0413942
BHLHE40 basic helix-loop-helix family, member e40 0.0410561
FXR1 fragile X mental retardation, autosomal homolog 1 0.0405111
HSPA8 heat shock 70kDa protein 8 0.0399441
LAMC2 laminin, gamma 2 0.0397166
NAV2 neuron navigator 2 0.0394389
ARRDC3 arrestin domain containing 3 0.0386845
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.03828
KDM3A lysine (K)-specific demethylase 3A 0.0376187
NDRG1 N-myc downstream regulated 1 0.0374577
RNF145 ring finger protein 145 0.0367987
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0359024
RAD21 RAD21 homolog (S. pombe) 0.0358269
UBA6 ubiquitin-like modifier activating enzyme 6 0.0346537
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0341897
TFG TRK-fused gene 0.0339406
APP amyloid beta (A4) precursor protein 0.033757
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0333925
FLNA filamin A, alpha 0.0331404
FLNB filamin B, beta 0.0327661
TPM3 tropomyosin 3 0.0326858
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0318537
MARCHF6 membrane associated ring-CH-type finger 6 0.0316431
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0305813
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0305441
IRF6 interferon regulatory factor 6 0.030176
MSN moesin 0.0299615
ZNF292 zinc finger protein 292 0.0297186
ADAM9 ADAM metallopeptidase domain 9 0.0293812
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0290092
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0288981
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0287927
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0283502
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0282588
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.028203
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0281294
CDC73 cell division cycle 73 0.0278671
CALR calreticulin 0.0277035
TNIP1 TNFAIP3 interacting protein 1 0.0273614
HMGB2 high mobility group box 2 0.0268749
CD46 CD46 molecule, complement regulatory protein 0.0268386
PCBP2 poly(rC) binding protein 2 0.0264607
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0259478
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0257077
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0256723
NUP58 nucleoporin 58 0.0256436
YTHDC1 YTH domain containing 1 0.0255698
IQGAP1 IQ motif containing GTPase activating protein 1 0.0251303
EEF2 eukaryotic translation elongation factor 2 0.0250339
TOP1 topoisomerase (DNA) I 0.0250248
RPL3 ribosomal protein L3 0.0248196
KDM6A lysine (K)-specific demethylase 6A 0.0247292
NCKAP1 NCK-associated protein 1 0.0246681
RPL4 ribosomal protein L4 0.0243754
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0241619
KMT2E lysine (K)-specific methyltransferase 2E 0.0236418
RAD23B RAD23 homolog B (S. cerevisiae) 0.0235934
SMG7 SMG7 nonsense mediated mRNA decay factor 0.023419
SPAG9 sperm associated antigen 9 0.0232387
WAC WW domain containing adaptor with coiled-coil 0.023082
ZC3H11A zinc finger CCCH-type containing 11A 0.0230238
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0227672
PAPOLA poly(A) polymerase alpha 0.022594
RBM39 RNA binding motif protein 39 0.0225728
USP9X ubiquitin specific peptidase 9, X-linked 0.0224863
CCNL1 cyclin L1 0.0223492
SMAD3 SMAD family member 3 0.0222288
SOD2 superoxide dismutase 2, mitochondrial 0.0219437
HELZ helicase with zinc finger 0.0217814
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0215566
USP3 ubiquitin specific peptidase 3 0.021551
ANLN anillin, actin binding protein 0.0214428
PGK1 phosphoglycerate kinase 1 0.0208948
RYK receptor-like tyrosine kinase 0.0208234
QKI QKI, KH domain containing, RNA binding 0.0207526

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.302641
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.268525
TMSB10 thymosin beta 10 -0.201912
ACTG1 actin gamma 1 -0.145603
PTMA prothymosin, alpha -0.125948
IFI27 interferon, alpha-inducible protein 27 -0.104438
RPL35A ribosomal protein L35a -0.100453
RPLP1 ribosomal protein, large, P1 -0.0819356
MT2A metallothionein 2A -0.0808377
S100A6 S100 calcium binding protein A6 -0.0766326
TPT1 tumor protein, translationally-controlled 1 -0.072939
RPS19 ribosomal protein S19 -0.070683
RPLP2 ribosomal protein, large, P2 -0.0705946
POTEF POTE ankyrin domain family, member F -0.0680658
RPL34 ribosomal protein L34 -0.065744
RPL8 ribosomal protein L8 -0.0631774
ISG15 ISG15 ubiquitin-like modifier -0.0612326
IFI6 interferon, alpha-inducible protein 6 -0.0596861
RPS29 ribosomal protein S29 -0.0569031
S100A9 S100 calcium binding protein A9 -0.0558829
HLA-B major histocompatibility complex, class I, B -0.0557141
S100A10 S100 calcium binding protein A10 -0.0548504
RPS13 ribosomal protein S13 -0.0523676
RPS6 ribosomal protein S6 -0.050663
EIF1 eukaryotic translation initiation factor 1 -0.0498844
IFITM3 interferon induced transmembrane protein 3 -0.0486874
CSTB cystatin B (stefin B) -0.0484077
RPS8 ribosomal protein S8 -0.0477497
RPL23 ribosomal protein L23 -0.0476288
SOX4 SRY (sex determining region Y)-box 4 -0.0475846
RPS23 ribosomal protein S23 -0.0468759
RPL32 ribosomal protein L32 -0.0461058
IFITM1 interferon induced transmembrane protein 1 -0.0433213
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0422527
RPS21 ribosomal protein S21 -0.0416041
MDK midkine (neurite growth-promoting factor 2) -0.0415234
RPL9 ribosomal protein L9 -0.0395908
WSB1 WD repeat and SOCS box containing 1 -0.0388423
HSPB1 heat shock 27kDa protein 1 -0.0370561
RPS14 ribosomal protein S14 -0.0366875
RPL28 ribosomal protein L28 -0.0354047
FBXO32 F-box protein 32 -0.034534
RPL31 ribosomal protein L31 -0.0329811
LY6E lymphocyte antigen 6 complex, locus E -0.0328632
RPL37A ribosomal protein L37a -0.0322678
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0318833
RPS15 ribosomal protein S15 -0.0318783
RPL37 ribosomal protein L37 -0.031434
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0313332
RPL36 ribosomal protein L36 -0.0311023
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0310628
RPL12 ribosomal protein L12 -0.0309812
HLA-A major histocompatibility complex, class I, A -0.0305182
KRT7 keratin 7, type II -0.0304874
IFI16 interferon, gamma-inducible protein 16 -0.0303997
RPL15 ribosomal protein L15 -0.0303737
RPS3 ribosomal protein S3 -0.0303455
CD63 CD63 molecule -0.0290945
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.028892
S100A11 S100 calcium binding protein A11 -0.028774
RAB7A RAB7A, member RAS oncogene family -0.0285686
RPS27 ribosomal protein S27 -0.0273937
RPS27A ribosomal protein S27a -0.0273228
EXT1 exostosin glycosyltransferase 1 -0.0271292
RPS10 ribosomal protein S10 -0.02683
RPS16 ribosomal protein S16 -0.0267725
RBM25 RNA binding motif protein 25 -0.0267216
H3-3B H3.3 histone B -0.0264032
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0255259
RPL38 ribosomal protein L38 -0.0255013
C15ORF48 chromosome 15 open reading frame 48 -0.025484
GNAS GNAS complex locus -0.025338
LGALS1 lectin, galactoside-binding, soluble, 1 -0.025077
RACK1 receptor for activated C kinase 1 -0.0246973
RPS25 ribosomal protein S25 -0.0245879
RPS24 ribosomal protein S24 -0.0244631
LOC102724023 ES1 protein homolog, mitochondrial -0.024241
CLDN4 claudin 4 -0.0242325
ENO2 enolase 2 (gamma, neuronal) -0.023655
PFN1 profilin 1 -0.02298
RPS11 ribosomal protein S11 -0.0229513
TM4SF1 transmembrane 4 L six family member 1 -0.0228648
LMNA lamin A/C -0.0227745
RPL36AL ribosomal protein L36a-like -0.0223458
MX2 MX dynamin-like GTPase 2 -0.0220315
BASP1 brain abundant, membrane attached signal protein 1 -0.0219124
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0217798
RPS5 ribosomal protein S5 -0.0216988
YY1 YY1 transcription factor -0.0216166
RPL36A ribosomal protein L36a -0.0216164
CCNI cyclin I -0.0215524
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0215357
ASTN2 astrotactin 2 -0.0215198
RPL7A ribosomal protein L7a -0.0214754
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0213585
HMGA1 high mobility group AT-hook 1 -0.0212884
EGR1 early growth response 1 -0.0209908
TXNIP thioredoxin interacting protein -0.0209725
TBCA tubulin folding cofactor A -0.0209696
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0209636