Rutin (trihydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.15138
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.120666
MCL1 myeloid cell leukemia 1 0.108984
ASPH aspartate beta-hydroxylase 0.092189
FNDC3B fibronectin type III domain containing 3B 0.0859952
TRIO trio Rho guanine nucleotide exchange factor 0.0838556
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0792613
PSD3 pleckstrin and Sec7 domain containing 3 0.0738026
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0721143
NRCAM neuronal cell adhesion molecule 0.0655541
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0645078
LIMCH1 LIM and calponin homology domains 1 0.0621573
NEK7 NIMA-related kinase 7 0.060492
DOCK4 dedicator of cytokinesis 4 0.0537622
ESYT2 extended synaptotagmin-like protein 2 0.0536592
MYOF myoferlin 0.0532388
DST dystonin 0.053223
FLNB filamin B, beta 0.0531008
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0519775
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517523
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0459703
GRAMD1B GRAM domain containing 1B 0.0453359
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0451836
MSN moesin 0.0434911
ERRFI1 ERBB receptor feedback inhibitor 1 0.0421115
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0397119
CXCL8 chemokine (C-X-C motif) ligand 8 0.0395581
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0394253
COL8A1 collagen, type VIII, alpha 1 0.0389888
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0384559
SOD2 superoxide dismutase 2, mitochondrial 0.0384261
PCBP2 poly(rC) binding protein 2 0.0371431
TGFBR1 transforming growth factor, beta receptor 1 0.0365875
FLNA filamin A, alpha 0.0365408
KDM6A lysine (K)-specific demethylase 6A 0.0360829
TNIP1 TNFAIP3 interacting protein 1 0.0353225
SMOC1 SPARC related modular calcium binding 1 0.0345897
CTIF CBP80/20-dependent translation initiation factor 0.0337372
OGA O-GlcNAcase 0.0330805
NBAS neuroblastoma amplified sequence 0.0330542
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0327928
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0326279
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0325979
KMT2C lysine (K)-specific methyltransferase 2C 0.0320431
COL4A6 collagen, type IV, alpha 6 0.0313821
FAM13A family with sequence similarity 13, member A 0.0312734
USP9X ubiquitin specific peptidase 9, X-linked 0.0311097
HELZ helicase with zinc finger 0.0310654
PTEN phosphatase and tensin homolog 0.0309044
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0306225
TPM3 tropomyosin 3 0.0305857
BIRC6 baculoviral IAP repeat containing 6 0.0302147
ITPRID2 ITPR interacting domain containing 2 0.030161
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0299613
COL5A2 collagen, type V, alpha 2 0.0299194
SFPQ splicing factor proline/glutamine-rich 0.0297407
DNER delta/notch-like EGF repeat containing 0.0292792
KYNU kynureninase 0.0291544
ZNF292 zinc finger protein 292 0.0290617
SAMD4A sterile alpha motif domain containing 4A 0.0286185
MYH9 myosin, heavy chain 9, non-muscle 0.0281285
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0278963
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0278244
PDE4D phosphodiesterase 4D, cAMP-specific 0.0273016
PDE10A phosphodiesterase 10A 0.0272429
GPC6 glypican 6 0.0268058
SPAG9 sperm associated antigen 9 0.026422
RPL3 ribosomal protein L3 0.0262789
CD109 CD109 molecule 0.0260772
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0259491
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0259021
CENPF centromere protein F, 350/400kDa 0.0258673
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0257336
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0257226
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0249501
NCOR2 nuclear receptor corepressor 2 0.0249318
CSNK1A1 casein kinase 1, alpha 1 0.0247792
RTN4 reticulon 4 0.0241491
IGFBP3 insulin-like growth factor binding protein 3 0.0239304
ZEB2 zinc finger E-box binding homeobox 2 0.0236972
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236592
HSPA8 heat shock 70kDa protein 8 0.0235538
AGFG1 ArfGAP with FG repeats 1 0.0232111
USP34 ubiquitin specific peptidase 34 0.0231034
UBA6 ubiquitin-like modifier activating enzyme 6 0.0230915
BCAR3 breast cancer anti-estrogen resistance 3 0.0226253
ADAM9 ADAM metallopeptidase domain 9 0.0226118
AVL9 AVL9 homolog (S. cerevisiase) 0.0225264
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0224908
ZFC3H1 zinc finger, C3H1-type containing 0.0224654
DPY19L1 dpy-19-like 1 (C. elegans) 0.0223411
ELL2 elongation factor, RNA polymerase II, 2 0.0222829
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0222277
CTSC cathepsin C 0.022212
CDC73 cell division cycle 73 0.0221796
NUP58 nucleoporin 58 0.0220172
EGLN1 egl-9 family hypoxia-inducible factor 1 0.021902
CSRP1 cysteine and glycine-rich protein 1 0.0216541
MYO10 myosin X 0.0215255
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0213236

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.309876
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175804
TPT1 tumor protein, translationally-controlled 1 -0.141562
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.121999
TMSB10 thymosin beta 10 -0.117041
PTMA prothymosin, alpha -0.103503
RPLP1 ribosomal protein, large, P1 -0.103453
VIM vimentin -0.100608
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.099583
FTL ferritin, light polypeptide -0.0978837
RPS6 ribosomal protein S6 -0.0974688
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0804388
RPL35A ribosomal protein L35a -0.0682585
RPS24 ribosomal protein S24 -0.0658941
RPS8 ribosomal protein S8 -0.0640322
RPL31 ribosomal protein L31 -0.0626032
RPL12 ribosomal protein L12 -0.0590152
RPS19 ribosomal protein S19 -0.057847
RPL26 ribosomal protein L26 -0.0575845
RPL37A ribosomal protein L37a -0.056129
HLA-B major histocompatibility complex, class I, B -0.0553707
RPLP0 ribosomal protein, large, P0 -0.0538513
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0516906
SOX4 SRY (sex determining region Y)-box 4 -0.0496659
RPL34 ribosomal protein L34 -0.049404
RPS27A ribosomal protein S27a -0.0484143
TM4SF1 transmembrane 4 L six family member 1 -0.0482152
RPS3 ribosomal protein S3 -0.0476388
WSB1 WD repeat and SOCS box containing 1 -0.0466308
S100A6 S100 calcium binding protein A6 -0.0464043
ACTG1 actin gamma 1 -0.0445971
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0442042
RPL38 ribosomal protein L38 -0.0434984
RPL7A ribosomal protein L7a -0.0434472
RPLP2 ribosomal protein, large, P2 -0.0424575
RPS21 ribosomal protein S21 -0.0416773
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0414219
RPL36A ribosomal protein L36a -0.0411213
NAP1L1 nucleosome assembly protein 1-like 1 -0.0408552
RPS12 ribosomal protein S12 -0.0407818
MT2A metallothionein 2A -0.0399272
GNAS GNAS complex locus -0.0394466
RPS29 ribosomal protein S29 -0.0391889
RPS16 ribosomal protein S16 -0.0379092
B2M beta-2-microglobulin -0.037413
RPL9 ribosomal protein L9 -0.0371705
S100A10 S100 calcium binding protein A10 -0.0370361
TFPI2 tissue factor pathway inhibitor 2 -0.0370014
RACK1 receptor for activated C kinase 1 -0.0368225
RPL37 ribosomal protein L37 -0.0363398
RPL23 ribosomal protein L23 -0.0362918
EIF1 eukaryotic translation initiation factor 1 -0.0353829
RPS14 ribosomal protein S14 -0.0350765
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0347229
RPS23 ribosomal protein S23 -0.0343067
RPL11 ribosomal protein L11 -0.0339709
RPS13 ribosomal protein S13 -0.0336743
RPL36 ribosomal protein L36 -0.0334036
SMYD3 SET and MYND domain containing 3 -0.0331518
IER3 immediate early response 3 -0.0297925
RPL32 ribosomal protein L32 -0.0289146
ASTN2 astrotactin 2 -0.0285786
RPL8 ribosomal protein L8 -0.0280684
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0274333
RPS27 ribosomal protein S27 -0.0274081
HLA-A major histocompatibility complex, class I, A -0.027017
RPL13A ribosomal protein L13a -0.0264184
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0262236
VDAC1 voltage-dependent anion channel 1 -0.0261395
RPS28 ribosomal protein S28 -0.0258925
RPL28 ribosomal protein L28 -0.0255565
RPS25 ribosomal protein S25 -0.0252894
RPL35 ribosomal protein L35 -0.0248828
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0248039
SRGN serglycin -0.0246563
INHBA inhibin, beta A -0.0245699
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0238966
PNRC1 proline-rich nuclear receptor coactivator 1 -0.023264
FNDC3A fibronectin type III domain containing 3A -0.0227637
SQSTM1 sequestosome 1 -0.0226342
RPL39 ribosomal protein L39 -0.0225675
RPL19 ribosomal protein L19 -0.0224912
FOXC1 forkhead box C1 -0.0221242
RPL27 ribosomal protein L27 -0.0216317
NTN4 netrin 4 -0.0215554
NCOA7 nuclear receptor coactivator 7 -0.0214701
TBCA tubulin folding cofactor A -0.0212681
RPL27A ribosomal protein L27a -0.0210252
RPS5 ribosomal protein S5 -0.0210214
RPS15 ribosomal protein S15 -0.020984
SMAD2 SMAD family member 2 -0.0208505
MAP7 microtubule-associated protein 7 -0.0204628
RPL30 ribosomal protein L30 -0.0203707
BTG1 B-cell translocation gene 1, anti-proliferative -0.0199994
ESM1 endothelial cell-specific molecule 1 -0.0196677
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0196591
KPNB1 karyopherin (importin) beta 1 -0.0195868
RPL5 ribosomal protein L5 -0.019572
LOC102724023 ES1 protein homolog, mitochondrial -0.0192731
RPL18 ribosomal protein L18 -0.0192233