Rutin (trihydrate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

138 genes differentially expressed following the Rutin (trihydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GOLGA4 golgin A4 0.150633
EIF1 eukaryotic translation initiation factor 1 0.122728
ZCCHC7 zinc finger, CCHC domain containing 7 0.11849
MSI2 musashi RNA-binding protein 2 0.11599
KMT2E lysine (K)-specific methyltransferase 2E 0.106831
ACTN4 actinin, alpha 4 0.0980458
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0972702
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0970747
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0957865
NBEA neurobeachin 0.0927008
PGK1 phosphoglycerate kinase 1 0.0879096
NDRG1 N-myc downstream regulated 1 0.0868966
FRYL FRY-like 0.0835911
MYO1E myosin IE 0.0757734
SLIT2 slit homolog 2 (Drosophila) 0.0754966
FTH1 ferritin, heavy polypeptide 1 0.0716983
SPAG9 sperm associated antigen 9 0.0714022
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0697993
SOD2 superoxide dismutase 2, mitochondrial 0.0614531
GMDS GDP-mannose 4,6-dehydratase 0.0614193
PTMA prothymosin, alpha 0.060653
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0601555
SLC38A1 solute carrier family 38, member 1 0.0528807
KMT2C lysine (K)-specific methyltransferase 2C 0.0522664
NKD1 naked cuticle homolog 1 (Drosophila) 0.0510264
APP amyloid beta (A4) precursor protein 0.0467555
GPC6 glypican 6 0.0459788
RPS6 ribosomal protein S6 0.0451037
RAB7A RAB7A, member RAS oncogene family 0.0449643
GNPDA1 glucosamine-6-phosphate deaminase 1 0.044435
LDHA lactate dehydrogenase A 0.0442615
DST dystonin 0.0420564
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0412533
TRIO trio Rho guanine nucleotide exchange factor 0.0399595
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0364275
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0311625
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0263002
ZFAND3 zinc finger, AN1-type domain 3 0.0260993
KDM2A lysine (K)-specific demethylase 2A 0.0246168
NAP1L1 nucleosome assembly protein 1-like 1 0.0242348
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0242334
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.024214
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0239568
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0236495
GRB10 growth factor receptor-bound protein 10 0.0227987
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0194159
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0186035
DLG1 discs, large homolog 1 (Drosophila) 0.0183974
DSCAM Down syndrome cell adhesion molecule 0.0175895
ATP9B ATPase, class II, type 9B 0.0172705
PARD3 par-3 family cell polarity regulator 0.0151405
SRPK2 SRSF protein kinase 2 0.0141663
FN1 fibronectin 1 0.0135427
JMJD1C jumonji domain containing 1C 0.0131601
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.00919611
TAS2R14 taste receptor, type 2, member 14 0.00822735
NAMPT nicotinamide phosphoribosyltransferase 0.00740645
AOPEP aminopeptidase O (putative) 0.00724544
TCF12 transcription factor 12 0.0063211
RIGI RNA sensor RIG-I 0.00149748
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 9.03983E-4

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.268175
EGFR epidermal growth factor receptor -0.167709
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.133739
PSD3 pleckstrin and Sec7 domain containing 3 -0.133613
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.124119
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.123477
LIMS1 LIM and senescent cell antigen-like domains 1 -0.113927
SAMD4A sterile alpha motif domain containing 4A -0.111626
FNDC3B fibronectin type III domain containing 3B -0.107075
AKAP12 A kinase (PRKA) anchor protein 12 -0.0946964
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0875442
MAML3 mastermind-like 3 (Drosophila) -0.086834
EFNA5 ephrin-A5 -0.0855174
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0853681
TMSB10 thymosin beta 10 -0.0817659
CDH13 cadherin 13 -0.0816919
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0799461
CD44 CD44 molecule (Indian blood group) -0.0739532
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0733377
INHBA inhibin, beta A -0.0708315
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0694399
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0638603
NALF1 NALCN channel auxiliary factor 1 -0.063289
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0631919
DOCK4 dedicator of cytokinesis 4 -0.0624199
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0594903
GPHN gephyrin -0.0564525
THSD4 thrombospondin, type I, domain containing 4 -0.0560091
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0548095
COL6A3 collagen, type VI, alpha 3 -0.0545607
AKAP13 A kinase (PRKA) anchor protein 13 -0.0541153
ENO1 enolase 1, (alpha) -0.0539601
FAM13A family with sequence similarity 13, member A -0.0531723
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0526523
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0524943
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0512517
VIM vimentin -0.0510804
MYOF myoferlin -0.0494778
WSB1 WD repeat and SOCS box containing 1 -0.0487416
EXT1 exostosin glycosyltransferase 1 -0.0467812
PDE10A phosphodiesterase 10A -0.0457081
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0450643
USP34 ubiquitin specific peptidase 34 -0.0435624
FNDC3A fibronectin type III domain containing 3A -0.0399218
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.038575
ZBTB20 zinc finger and BTB domain containing 20 -0.0375336
ASPH aspartate beta-hydroxylase -0.0371656
ALCAM activated leukocyte cell adhesion molecule -0.0331936
SLTM SAFB-like, transcription modulator -0.0330198
SETD5 SET domain containing 5 -0.0328996
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0322891
PDLIM5 PDZ and LIM domain 5 -0.0313587
PRRC2C proline-rich coiled-coil 2C -0.0285551
WDFY3 WD repeat and FYVE domain containing 3 -0.0280009
MED13L mediator complex subunit 13-like -0.0277233
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0258587
RORA RAR-related orphan receptor A -0.0254483
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0222903
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0205741
SBF2 SET binding factor 2 -0.0190316
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0190141
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0189631
DOCK5 dedicator of cytokinesis 5 -0.0173518
MARCHF7 membrane associated ring-CH-type finger 7 -0.0173502
TMSB4X thymosin beta 4, X-linked -0.0147398
BBX bobby sox homolog (Drosophila) -0.0131512
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0127113
TPT1 tumor protein, translationally-controlled 1 -0.00953457
TXNRD1 thioredoxin reductase 1 -0.0092355
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00837504
SMAD3 SMAD family member 3 -0.00776765
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00731564
CUX1 cut-like homeobox 1 -0.00594199
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.00495224
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.00489057
ESYT2 extended synaptotagmin-like protein 2 -0.00482123
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00232628