Rutin (trihydrate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.166418
KRT17 keratin 17, type I 0.0864053
MYH9 myosin, heavy chain 9, non-muscle 0.0843861
SMAD3 SMAD family member 3 0.080156
MACF1 microtubule-actin crosslinking factor 1 0.0796068
LAMC2 laminin, gamma 2 0.072116
TNIP1 TNFAIP3 interacting protein 1 0.064177
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.063426
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0618946
CTNND1 catenin (cadherin-associated protein), delta 1 0.0601317
KRT18 keratin 18, type I 0.0594924
PLEC plectin 0.0554696
BHLHE40 basic helix-loop-helix family, member e40 0.0544289
SPTBN1 spectrin, beta, non-erythrocytic 1 0.053727
ARRDC3 arrestin domain containing 3 0.0532818
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0517188
SPAG9 sperm associated antigen 9 0.051598
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0515527
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0507233
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0502598
MYO6 myosin VI 0.0502077
G0S2 G0/G1 switch 2 0.0498634
ACTN4 actinin, alpha 4 0.048855
DSPP dentin sialophosphoprotein 0.0487968
MUC4 mucin 4, cell surface associated 0.0485724
DSCAM Down syndrome cell adhesion molecule 0.0472278
KDM3A lysine (K)-specific demethylase 3A 0.0466109
LMO7 LIM domain 7 0.0461429
CALR calreticulin 0.0446923
NAV2 neuron navigator 2 0.0445339
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0441842
DDIT4 DNA-damage-inducible transcript 4 0.0424125
TRIO trio Rho guanine nucleotide exchange factor 0.042163
TSC22D2 TSC22 domain family, member 2 0.0416246
ZFAND3 zinc finger, AN1-type domain 3 0.0414249
WAC WW domain containing adaptor with coiled-coil 0.0394778
AFDN afadin, adherens junction formation factor 0.0385203
OGA O-GlcNAcase 0.0384078
APP amyloid beta (A4) precursor protein 0.0383782
MYO5B myosin VB 0.0375551
KDM6A lysine (K)-specific demethylase 6A 0.0367575
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0364744
RPL19 ribosomal protein L19 0.0364381
UBE2H ubiquitin-conjugating enzyme E2H 0.0362386
ARGLU1 arginine and glutamate rich 1 0.0361289
TMSB4X thymosin beta 4, X-linked 0.0353492
SOD2 superoxide dismutase 2, mitochondrial 0.0342286
FLNB filamin B, beta 0.0334517
OSBPL3 oxysterol binding protein-like 3 0.0329466
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0321639
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0320665
ATP13A3 ATPase type 13A3 0.0311249
FLNA filamin A, alpha 0.0306444
NUMA1 nuclear mitotic apparatus protein 1 0.0298183
SEPTIN9 septin 9 0.0297512
PELI1 pellino E3 ubiquitin protein ligase 1 0.0293058
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0289841
NCOA3 nuclear receptor coactivator 3 0.028893
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0288681
PICALM phosphatidylinositol binding clathrin assembly protein 0.0288433
BCAR3 breast cancer anti-estrogen resistance 3 0.0287072
APLP2 amyloid beta (A4) precursor-like protein 2 0.0282664
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0281735
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0280824
KRT8 keratin 8, type II 0.0278683
ERRFI1 ERBB receptor feedback inhibitor 1 0.0277205
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0276135
TM9SF2 transmembrane 9 superfamily member 2 0.0275357
TJP2 tight junction protein 2 0.0272607
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0270817
AFAP1 actin filament associated protein 1 0.0270601
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0269356
RBM33 RNA binding motif protein 33 0.0267705
GRB10 growth factor receptor-bound protein 10 0.02676
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0264264
LASP1 LIM and SH3 protein 1 0.0262211
FNDC3B fibronectin type III domain containing 3B 0.025805
SAMD4A sterile alpha motif domain containing 4A 0.0256006
USP12 ubiquitin specific peptidase 12 0.0250327
LRRC1 leucine rich repeat containing 1 0.0249415
RCOR1 REST corepressor 1 0.0246571
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0240609
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0238276
BMAL2 basic helix-loop-helix ARNT like 2 0.023673
NCKAP1 NCK-associated protein 1 0.0234272
RIOK3 RIO kinase 3 0.0233331
IRF6 interferon regulatory factor 6 0.0230159
HSPA8 heat shock 70kDa protein 8 0.0228475
EEF2 eukaryotic translation elongation factor 2 0.0228393
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0224614
EIF4B eukaryotic translation initiation factor 4B 0.0224098
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0223278
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0222445
RIMKLB ribosomal modification protein rimK-like family member B 0.0221615
ANXA11 annexin A11 0.0220724
SERINC1 serine incorporator 1 0.022002
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0216649
RYK receptor-like tyrosine kinase 0.0212603
FXR1 fragile X mental retardation, autosomal homolog 1 0.0211905
NUP153 nucleoporin 153kDa 0.0211036

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.456799
RPS6 ribosomal protein S6 -0.11242
RPL35A ribosomal protein L35a -0.0846425
HMGA1 high mobility group AT-hook 1 -0.0826384
TMSB10 thymosin beta 10 -0.0753387
IFI27 interferon, alpha-inducible protein 27 -0.0745469
RPL23 ribosomal protein L23 -0.0739583
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0714998
FTL ferritin, light polypeptide -0.0668914
TXNIP thioredoxin interacting protein -0.0665598
POTEF POTE ankyrin domain family, member F -0.0653574
EGR1 early growth response 1 -0.0635478
TPT1 tumor protein, translationally-controlled 1 -0.0630364
LOC102724023 ES1 protein homolog, mitochondrial -0.0598902
ACTG1 actin gamma 1 -0.0574647
RPS13 ribosomal protein S13 -0.0567827
MT2A metallothionein 2A -0.0566726
RPLP1 ribosomal protein, large, P1 -0.0561348
LY6E lymphocyte antigen 6 complex, locus E -0.053857
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0531605
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0531453
RPS19 ribosomal protein S19 -0.0513792
TOP2A topoisomerase (DNA) II alpha 170kDa -0.051296
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0506283
RPS8 ribosomal protein S8 -0.0500968
RACK1 receptor for activated C kinase 1 -0.0495473
B2M beta-2-microglobulin -0.0462027
RPL8 ribosomal protein L8 -0.0453651
RPS15 ribosomal protein S15 -0.0450325
SMC4 structural maintenance of chromosomes 4 -0.0431538
LDHA lactate dehydrogenase A -0.0431
FOSL1 FOS-like antigen 1 -0.0418309
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0414571
DLG1 discs, large homolog 1 (Drosophila) -0.0408157
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0399133
RPL12 ribosomal protein L12 -0.0398355
S100A6 S100 calcium binding protein A6 -0.0395954
RPS21 ribosomal protein S21 -0.0395586
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0393652
KRT19 keratin 19, type I -0.037767
FTH1 ferritin, heavy polypeptide 1 -0.0374768
S100A9 S100 calcium binding protein A9 -0.0368228
KTN1 kinectin 1 (kinesin receptor) -0.0366555
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0360084
RPS5 ribosomal protein S5 -0.0353421
RPL28 ribosomal protein L28 -0.0352456
ZBTB20 zinc finger and BTB domain containing 20 -0.0351288
S100A10 S100 calcium binding protein A10 -0.0348425
EMP1 epithelial membrane protein 1 -0.0348373
RPLP2 ribosomal protein, large, P2 -0.0344301
RPL31 ribosomal protein L31 -0.0334766
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0328582
RPS14 ribosomal protein S14 -0.032689
VIM vimentin -0.0317848
PKM pyruvate kinase, muscle -0.031517
RPS23 ribosomal protein S23 -0.0312193
TM4SF1 transmembrane 4 L six family member 1 -0.0300172
HLA-A major histocompatibility complex, class I, A -0.0297718
RPS24 ribosomal protein S24 -0.0294274
RPL34 ribosomal protein L34 -0.0288537
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.028562
IFITM1 interferon induced transmembrane protein 1 -0.028214
PTMA prothymosin, alpha -0.0281555
TAPBP TAP binding protein (tapasin) -0.0280486
BPTF bromodomain PHD finger transcription factor -0.0277036
RPL36 ribosomal protein L36 -0.0276977
MX2 MX dynamin-like GTPase 2 -0.0275472
HMGB1 high mobility group box 1 -0.0275411
PFN1 profilin 1 -0.027257
RPS16 ribosomal protein S16 -0.0271768
CENPF centromere protein F, 350/400kDa -0.0268214
RPS29 ribosomal protein S29 -0.0266886
TPM4 tropomyosin 4 -0.0266592
IFITM3 interferon induced transmembrane protein 3 -0.0263813
CAV1 caveolin 1, caveolae protein, 22kDa -0.02577
CCNI cyclin I -0.0257636
NF1 neurofibromin 1 -0.0256407
PCLO piccolo presynaptic cytomatrix protein -0.0255064
MAML2 mastermind-like 2 (Drosophila) -0.02541
CD44 CD44 molecule (Indian blood group) -0.0254092
WFDC2 WAP four-disulfide core domain 2 -0.025319
IFI16 interferon, gamma-inducible protein 16 -0.0250248
NFIB nuclear factor I/B -0.0250139
RUNX1 runt-related transcription factor 1 -0.0248707
EFNA5 ephrin-A5 -0.0245463
AKAP9 A kinase (PRKA) anchor protein 9 -0.0245405
RPLP0 ribosomal protein, large, P0 -0.0244778
GOLGB1 golgin B1 -0.0244513
MX1 MX dynamin-like GTPase 1 -0.0243912
CBX3 chromobox homolog 3 -0.0242999
SMYD3 SET and MYND domain containing 3 -0.023958
RPL32 ribosomal protein L32 -0.0237508
RPL35 ribosomal protein L35 -0.0237299
BLZF1 basic leucine zipper nuclear factor 1 -0.0235475
ANXA1 annexin A1 -0.0234717
BTG1 B-cell translocation gene 1, anti-proliferative -0.0234692
RPL18 ribosomal protein L18 -0.0233871
RPL9 ribosomal protein L9 -0.0232722
DEK DEK proto-oncogene -0.0232313
S100A11 S100 calcium binding protein A11 -0.0231697