| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rutin (trihydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rutin (trihydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.327395 |
| VGF | VGF nerve growth factor inducible | 0.111283 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0890822 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0823308 |
| TENM1 | teneurin transmembrane protein 1 | 0.0740461 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0694798 |
| FAT1 | FAT atypical cadherin 1 | 0.0640086 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0615723 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0576152 |
| PEG10 | paternally expressed 10 | 0.0567383 |
| CENPF | centromere protein F, 350/400kDa | 0.0554245 |
| ZNF292 | zinc finger protein 292 | 0.0541339 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0539025 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0500333 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0489731 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0478462 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0475593 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0433631 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0430919 |
| XPO1 | exportin 1 | 0.0421832 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0419681 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0418231 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0417782 |
| MATR3 | matrin 3 | 0.0411905 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0410772 |
| GRAMD4 | GRAM domain containing 4 | 0.0409319 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.040656 |
| RTN4 | reticulon 4 | 0.038674 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0385852 |
| PCBP2 | poly(rC) binding protein 2 | 0.0377528 |
| CADM1 | cell adhesion molecule 1 | 0.035888 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0345244 |
| PCM1 | pericentriolar material 1 | 0.0340962 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0338535 |
| PGK1 | phosphoglycerate kinase 1 | 0.0331364 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0330733 |
| RIT2 | Ras-like without CAAX 2 | 0.0328198 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0321608 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0316057 |
| ENO1 | enolase 1, (alpha) | 0.0314855 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.031211 |
| AOPEP | aminopeptidase O (putative) | 0.0311921 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.031155 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0308791 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0308084 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0301731 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0301234 |
| RPL7 | ribosomal protein L7 | 0.0300605 |
| MKI67 | marker of proliferation Ki-67 | 0.0299825 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0297877 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0289456 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.028427 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0280638 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0279232 |
| MTMR7 | myotubularin related protein 7 | 0.0278079 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0275691 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.0275611 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0274753 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0274406 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0273944 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0272798 |
| NLGN1 | neuroligin 1 | 0.0271509 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0269196 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0267546 |
| TPM3 | tropomyosin 3 | 0.0264561 |
| DST | dystonin | 0.0261787 |
| LMNB1 | lamin B1 | 0.0260493 |
| IRS2 | insulin receptor substrate 2 | 0.0258869 |
| STMN1 | stathmin 1 | 0.025661 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0256575 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0255673 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.025547 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0255232 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0251444 |
| TXNRD1 | thioredoxin reductase 1 | 0.0249841 |
| CA8 | carbonic anhydrase VIII | 0.0248512 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0246583 |
| YY1AP1 | YY1 associated protein 1 | 0.024501 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0243003 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0242413 |
| ECT2 | epithelial cell transforming 2 | 0.0241209 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0239562 |
| ADAR | adenosine deaminase, RNA-specific | 0.0239366 |
| NCKAP1 | NCK-associated protein 1 | 0.0236301 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0235511 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0231568 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0230762 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0230706 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0230421 |
| NBAS | neuroblastoma amplified sequence | 0.0229435 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0227841 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.022766 |
| SPAG5 | sperm associated antigen 5 | 0.0227638 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.0227129 |
| CABIN1 | calcineurin binding protein 1 | 0.0225759 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0224398 |
| NCAM1 | neural cell adhesion molecule 1 | 0.022413 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0223465 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0223224 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0221425 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.0886678 |
| SNTG1 | syntrophin, gamma 1 | -0.0862983 |
| NRG1 | neuregulin 1 | -0.0817626 |
| GPC5 | glypican 5 | -0.0569159 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.055594 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0535685 |
| STC1 | stanniocalcin 1 | -0.0510383 |
| KIF26B | kinesin family member 26B | -0.0494264 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0443946 |
| RORA | RAR-related orphan receptor A | -0.0437382 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0437329 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.042648 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0413257 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0412097 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.040912 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0407111 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0399936 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0396737 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0359471 |
| PTCHD4 | patched domain containing 4 | -0.0351622 |
| NBEA | neurobeachin | -0.0331007 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0329746 |
| EGR1 | early growth response 1 | -0.032536 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0309647 |
| CDK13 | cyclin-dependent kinase 13 | -0.0306957 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.030614 |
| HM13 | histocompatibility (minor) 13 | -0.0299233 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0293924 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0289469 |
| ACTG1 | actin gamma 1 | -0.0286382 |
| SCG2 | secretogranin II | -0.0286314 |
| MCL1 | myeloid cell leukemia 1 | -0.0283813 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0281734 |
| ESRRG | estrogen-related receptor gamma | -0.0276608 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0276262 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0270556 |
| HOMER1 | homer scaffolding protein 1 | -0.0269605 |
| SMYD3 | SET and MYND domain containing 3 | -0.0268482 |
| DENND4A | DENN/MADD domain containing 4A | -0.0262152 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0258213 |
| MAP1B | microtubule-associated protein 1B | -0.0256859 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0239333 |
| NELL1 | NEL-like 1 (chicken) | -0.02348 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0232361 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0222812 |
| MYT1L | myelin transcription factor 1-like | -0.0222059 |
| GNAS | GNAS complex locus | -0.0219438 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0212903 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0210938 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.020478 |
| FOXC1 | forkhead box C1 | -0.0202897 |
| SETX | senataxin | -0.0199665 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0197593 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0197287 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0195867 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0195712 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0195674 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0194977 |
| CNKSR3 | CNKSR family member 3 | -0.019491 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0194063 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | -0.0192874 |
| EPHA6 | EPH receptor A6 | -0.0192107 |
| ONECUT2 | one cut homeobox 2 | -0.0191436 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.018865 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0186985 |
| ZNF804A | zinc finger protein 804A | -0.0186267 |
| MT2A | metallothionein 2A | -0.0185184 |
| KLHL29 | kelch-like family member 29 | -0.0184735 |
| RPL37A | ribosomal protein L37a | -0.0182604 |
| TMEM165 | transmembrane protein 165 | -0.0180254 |
| ATF6 | activating transcription factor 6 | -0.0178901 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0178811 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0177377 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.017711 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.017521 |
| SCFD1 | sec1 family domain containing 1 | -0.0174733 |
| ZFHX3 | zinc finger homeobox 3 | -0.0169111 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0167916 |
| RPL37 | ribosomal protein L37 | -0.0164947 |
| JUN | jun proto-oncogene | -0.0164828 |
| NAV2 | neuron navigator 2 | -0.0164389 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.016391 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0161598 |
| SP100 | SP100 nuclear antigen | -0.0160607 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0160591 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0158744 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0158635 |
| INTS6 | integrator complex subunit 6 | -0.0154666 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0154347 |
| NDRG1 | N-myc downstream regulated 1 | -0.0150194 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0149787 |
| S100A9 | S100 calcium binding protein A9 | -0.0148335 |
| EGFR | epidermal growth factor receptor | -0.0148102 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0147904 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0147799 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.014381 |
| SVIL | supervillin | -0.0142046 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0141892 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | -0.0141488 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0141262 |
