Rutin (trihydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.08796
ZNF292 zinc finger protein 292 0.0692209
KDM3A lysine (K)-specific demethylase 3A 0.0658754
DSCAM Down syndrome cell adhesion molecule 0.0595848
ZEB1 zinc finger E-box binding homeobox 1 0.0537124
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.053156
CAMTA1 calmodulin binding transcription activator 1 0.0518937
EZR ezrin 0.051872
FLNB filamin B, beta 0.0518261
PDGFC platelet derived growth factor C 0.0516363
TMSB4X thymosin beta 4, X-linked 0.0509604
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0503704
NCKAP1 NCK-associated protein 1 0.0484184
EML4 echinoderm microtubule associated protein like 4 0.0468403
RTN4 reticulon 4 0.0465052
NAMPT nicotinamide phosphoribosyltransferase 0.0436525
CDC73 cell division cycle 73 0.0429203
RBM39 RNA binding motif protein 39 0.0425561
QKI QKI, KH domain containing, RNA binding 0.0399854
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0399347
PDE4D phosphodiesterase 4D, cAMP-specific 0.0389108
FAT1 FAT atypical cadherin 1 0.0383768
ADAM10 ADAM metallopeptidase domain 10 0.0366015
SOX6 SRY (sex determining region Y)-box 6 0.0363
MSI2 musashi RNA-binding protein 2 0.0355531
ZFAND3 zinc finger, AN1-type domain 3 0.0353143
ECT2 epithelial cell transforming 2 0.0351988
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0349276
TMEM65 transmembrane protein 65 0.0335938
TGFBR3 transforming growth factor, beta receptor III 0.0335184
GSK3B glycogen synthase kinase 3 beta 0.0330669
PICALM phosphatidylinositol binding clathrin assembly protein 0.0330625
KDM6A lysine (K)-specific demethylase 6A 0.0329966
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0328717
TXNIP thioredoxin interacting protein 0.0313729
YAP1 Yes-associated protein 1 0.0306273
ZNF608 zinc finger protein 608 0.030368
HELZ helicase with zinc finger 0.0300331
GNPDA1 glucosamine-6-phosphate deaminase 1 0.029956
KMT2E lysine (K)-specific methyltransferase 2E 0.029926
CCNL1 cyclin L1 0.0296822
WAC WW domain containing adaptor with coiled-coil 0.0294488
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0289535
HSPA8 heat shock 70kDa protein 8 0.0289396
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0289224
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.028822
BIRC6 baculoviral IAP repeat containing 6 0.0283014
OGA O-GlcNAcase 0.0282322
FNDC3B fibronectin type III domain containing 3B 0.0280742
PRELID2 PRELI domain containing 2 0.0280175
RPL3 ribosomal protein L3 0.0279464
PTBP2 polypyrimidine tract binding protein 2 0.0274451
CASC3 cancer susceptibility candidate 3 0.0272213
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0271723
ZMYM2 zinc finger, MYM-type 2 0.0270031
HOOK2 hook microtubule-tethering protein 2 0.0266148
ADAM9 ADAM metallopeptidase domain 9 0.0263524
PUM2 pumilio RNA-binding family member 2 0.0263511
PUM1 pumilio RNA-binding family member 1 0.0261755
GLS2 glutaminase 2 (liver, mitochondrial) 0.0259914
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.025833
BRWD1 bromodomain and WD repeat domain containing 1 0.02542
CTNND1 catenin (cadherin-associated protein), delta 1 0.025316
SSBP2 single-stranded DNA binding protein 2 0.0249191
XPO1 exportin 1 0.0246543
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0246425
XRN2 5'-3' exoribonuclease 2 0.0243941
CRY1 cryptochrome circadian clock 1 0.0243916
PYGB phosphorylase, glycogen; brain 0.0242545
NBAS neuroblastoma amplified sequence 0.0241796
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0241456
TLK2 tousled-like kinase 2 0.0241138
PGK1 phosphoglycerate kinase 1 0.0239738
ZNF644 zinc finger protein 644 0.0238589
UBQLN1 ubiquilin 1 0.0238176
SREBF2 sterol regulatory element binding transcription factor 2 0.0235975
NUP58 nucleoporin 58 0.0235852
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0235573
IGF1R insulin-like growth factor 1 receptor 0.0233461
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.023264
SFPQ splicing factor proline/glutamine-rich 0.0231968
ADAM17 ADAM metallopeptidase domain 17 0.0230782
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0230678
PTK2 protein tyrosine kinase 2 0.0228461
PRPF38B pre-mRNA processing factor 38B 0.0226274
ZMIZ1 zinc finger, MIZ-type containing 1 0.0223371
YTHDC1 YTH domain containing 1 0.0220831
HJURP Holliday junction recognition protein 0.0219797
TFG TRK-fused gene 0.0217335
ANKRD11 ankyrin repeat domain 11 0.0212821
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0211586
STAG2 stromal antigen 2 0.0210989
RBM33 RNA binding motif protein 33 0.0208787
PER1 period circadian clock 1 0.0208672
YEATS2 YEATS domain containing 2 0.0208433
WDR43 WD repeat domain 43 0.0207959
SPAG9 sperm associated antigen 9 0.0207901
SEC23A Sec23 homolog A (S. cerevisiae) 0.0207716
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.020347
TMEM39A transmembrane protein 39A 0.0201921

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.202787
PTMA prothymosin, alpha -0.190856
RPS6 ribosomal protein S6 -0.0999382
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0994476
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0849342
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0831583
ACTG1 actin gamma 1 -0.0697189
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0694761
FOXP1 forkhead box P1 -0.069039
TPT1 tumor protein, translationally-controlled 1 -0.0555417
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0531053
RPS8 ribosomal protein S8 -0.0530128
NBEA neurobeachin -0.0522157
RPL35A ribosomal protein L35a -0.048564
PDE4B phosphodiesterase 4B, cAMP-specific -0.0485152
PFN1 profilin 1 -0.0473733
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0459617
RPLP1 ribosomal protein, large, P1 -0.0427913
FTL ferritin, light polypeptide -0.0389698
RPLP0 ribosomal protein, large, P0 -0.0385392
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0382751
S100A6 S100 calcium binding protein A6 -0.0370231
RPL31 ribosomal protein L31 -0.0361373
RPS19 ribosomal protein S19 -0.0355916
ZMYND8 zinc finger, MYND-type containing 8 -0.0350028
RPS3 ribosomal protein S3 -0.0345721
CCND1 cyclin D1 -0.0334616
RPL26 ribosomal protein L26 -0.0319985
RPLP2 ribosomal protein, large, P2 -0.0314414
DPYD dihydropyrimidine dehydrogenase -0.0311916
ARL4C ADP-ribosylation factor-like 4C -0.0305303
BPTF bromodomain PHD finger transcription factor -0.0304195
RPL34 ribosomal protein L34 -0.0299324
POTEF POTE ankyrin domain family, member F -0.0296916
RPL9 ribosomal protein L9 -0.029631
HSPB1 heat shock 27kDa protein 1 -0.0289607
RPL8 ribosomal protein L8 -0.0284796
RPL11 ribosomal protein L11 -0.0276719
S100A4 S100 calcium binding protein A4 -0.0274683
TXNRD1 thioredoxin reductase 1 -0.0272999
RPL7A ribosomal protein L7a -0.0272619
S100A9 S100 calcium binding protein A9 -0.0268902
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0268398
MT2A metallothionein 2A -0.0261893
DUSP6 dual specificity phosphatase 6 -0.0258489
RPL37A ribosomal protein L37a -0.0257143
RPL12 ribosomal protein L12 -0.0256997
RPL23 ribosomal protein L23 -0.0255534
LOC102724023 ES1 protein homolog, mitochondrial -0.025539
PRDX2 peroxiredoxin 2 -0.0246612
NPAS2 neuronal PAS domain protein 2 -0.0244938
RPS25 ribosomal protein S25 -0.0243758
DSTN destrin (actin depolymerizing factor) -0.0238916
TTC3 tetratricopeptide repeat domain 3 -0.023881
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0237641
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0236822
GLI3 GLI family zinc finger 3 -0.0236753
RPL5 ribosomal protein L5 -0.0233419
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0232363
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.023219
BMP10 bone morphogenetic protein 10 -0.0230099
CCNI cyclin I -0.0227034
TPM4 tropomyosin 4 -0.0225488
RPS13 ribosomal protein S13 -0.0223748
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0221272
RPS27A ribosomal protein S27a -0.0220858
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0217901
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0216876
RACK1 receptor for activated C kinase 1 -0.0215007
RPL19 ribosomal protein L19 -0.021408
VDAC1 voltage-dependent anion channel 1 -0.0212896
RPL32 ribosomal protein L32 -0.0212185
DLG1 discs, large homolog 1 (Drosophila) -0.0210808
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0210187
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0209773
RPL36 ribosomal protein L36 -0.0209286
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0208376
RPS16 ribosomal protein S16 -0.0207946
RPL27A ribosomal protein L27a -0.020525
RPS12 ribosomal protein S12 -0.0204282
ANKRD17 ankyrin repeat domain 17 -0.0200026
RPS29 ribosomal protein S29 -0.0198351
MTDH metadherin -0.0195229
RPS5 ribosomal protein S5 -0.0193127
SMC3 structural maintenance of chromosomes 3 -0.0191825
RPL10A ribosomal protein L10a -0.0189409
PDE7B phosphodiesterase 7B -0.0189041
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0186771
EIF5B eukaryotic translation initiation factor 5B -0.0186137
RPL13A ribosomal protein L13a -0.018607
HMGB1 high mobility group box 1 -0.0185199
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0184538
RPS11 ribosomal protein S11 -0.0184242
TMSB10 thymosin beta 10 -0.0181972
CALR calreticulin -0.0181721
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0178755
GCLM glutamate-cysteine ligase, modifier subunit -0.0174261
TAS2R14 taste receptor, type 2, member 14 -0.0173211
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0173206
S100A10 S100 calcium binding protein A10 -0.0172403