Rutin (trihydrate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.333055
FN1 fibronectin 1 0.267203
MYH9 myosin, heavy chain 9, non-muscle 0.211245
FNDC3B fibronectin type III domain containing 3B 0.122354
NAV2 neuron navigator 2 0.100252
TRIO trio Rho guanine nucleotide exchange factor 0.095718
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0943928
FRMD4A FERM domain containing 4A 0.0786622
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0734468
MYOF myoferlin 0.0731866
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0706706
FLNA filamin A, alpha 0.0693747
MSN moesin 0.0679483
TNIP1 TNFAIP3 interacting protein 1 0.0618639
PDE10A phosphodiesterase 10A 0.0580717
OGA O-GlcNAcase 0.0566171
SMAD3 SMAD family member 3 0.0559603
CENPF centromere protein F, 350/400kDa 0.0559112
VCL vinculin 0.055247
CADM1 cell adhesion molecule 1 0.0533183
USP9X ubiquitin specific peptidase 9, X-linked 0.0531626
ARRDC3 arrestin domain containing 3 0.0514072
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0489133
TENT5A terminal nucleotidyltransferase 5A 0.0485867
RB1CC1 RB1-inducible coiled-coil 1 0.0479949
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0477219
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0470763
PABPC1 poly(A) binding protein, cytoplasmic 1 0.046758
SPAG9 sperm associated antigen 9 0.0464728
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0455133
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0449993
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0444526
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0442684
DST dystonin 0.0436781
MKI67 marker of proliferation Ki-67 0.0406786
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0403814
HELZ helicase with zinc finger 0.0399565
PCBP2 poly(rC) binding protein 2 0.0397937
ZMIZ1 zinc finger, MIZ-type containing 1 0.0395553
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0391196
ZNF292 zinc finger protein 292 0.0382046
ELL2 elongation factor, RNA polymerase II, 2 0.037563
LAMP2 lysosomal-associated membrane protein 2 0.0362306
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0358635
ANLN anillin, actin binding protein 0.0357457
JMJD1C jumonji domain containing 1C 0.0356538
EEF2 eukaryotic translation elongation factor 2 0.0341874
NAMPT nicotinamide phosphoribosyltransferase 0.0337173
TNS3 tensin 3 0.0326931
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0324824
ACTN4 actinin, alpha 4 0.0320419
AFDN afadin, adherens junction formation factor 0.0319945
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0318246
PICALM phosphatidylinositol binding clathrin assembly protein 0.0314221
SBF2 SET binding factor 2 0.0310681
CCNL1 cyclin L1 0.0308889
SHB Src homology 2 domain containing adaptor protein B 0.0308041
FNIP1 folliculin interacting protein 1 0.0302098
COL6A3 collagen, type VI, alpha 3 0.0298033
CEP250 centrosomal protein 250kDa 0.029628
PRELID2 PRELI domain containing 2 0.0291544
ATXN1 ataxin 1 0.0288836
FLNB filamin B, beta 0.028423
LOXL2 lysyl oxidase-like 2 0.0283817
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0281358
APLP2 amyloid beta (A4) precursor-like protein 2 0.0279316
KDM6A lysine (K)-specific demethylase 6A 0.0277823
ICAM1 intercellular adhesion molecule 1 0.0275934
TSC22D2 TSC22 domain family, member 2 0.0274267
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0272124
EXT1 exostosin glycosyltransferase 1 0.0270795
UBA6 ubiquitin-like modifier activating enzyme 6 0.0269598
MX1 MX dynamin-like GTPase 1 0.0263462
COL8A1 collagen, type VIII, alpha 1 0.0262056
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0254147
TRIP12 thyroid hormone receptor interactor 12 0.0251472
RBM39 RNA binding motif protein 39 0.0249623
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0249623
CKAP5 cytoskeleton associated protein 5 0.0247106
RTN4 reticulon 4 0.0242184
DIAPH3 diaphanous-related formin 3 0.0238393
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0236651
GOLGA4 golgin A4 0.0234456
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0231695
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0230376
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0230351
PRKCSH protein kinase C substrate 80K-H 0.0229933
AKAP13 A kinase (PRKA) anchor protein 13 0.0228219
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0228206
DENND5A DENN/MADD domain containing 5A 0.022695
KIF4A kinesin family member 4A 0.0226877
CORO1C coronin, actin binding protein, 1C 0.0226518
VMP1 vacuole membrane protein 1 0.0220969
DUSP5 dual specificity phosphatase 5 0.0217985
ESYT2 extended synaptotagmin-like protein 2 0.0215322
ADAR adenosine deaminase, RNA-specific 0.0212982
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0207709
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0207326
SFPQ splicing factor proline/glutamine-rich 0.020682
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0205922

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.205844
HLA-B major histocompatibility complex, class I, B -0.139877
IGFBP3 insulin-like growth factor binding protein 3 -0.117433
IER3 immediate early response 3 -0.114714
FTL ferritin, light polypeptide -0.108879
AKAP12 A kinase (PRKA) anchor protein 12 -0.108058
TPT1 tumor protein, translationally-controlled 1 -0.105495
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0880093
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0841798
TMSB10 thymosin beta 10 -0.0755487
GLIS3 GLIS family zinc finger 3 -0.0744784
HMGA2 high mobility group AT-hook 2 -0.0634398
MT2A metallothionein 2A -0.0617143
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0615555
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0561076
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.055436
BTG1 B-cell translocation gene 1, anti-proliferative -0.0544825
HLA-A major histocompatibility complex, class I, A -0.0523045
FTH1 ferritin, heavy polypeptide 1 -0.0521877
ZMYND8 zinc finger, MYND-type containing 8 -0.0506348
RPS6 ribosomal protein S6 -0.0496739
RPS8 ribosomal protein S8 -0.0471589
BASP1 brain abundant, membrane attached signal protein 1 -0.0445231
CDH13 cadherin 13 -0.0417999
NDRG1 N-myc downstream regulated 1 -0.0409427
ADM adrenomedullin -0.040929
B2M beta-2-microglobulin -0.0392941
SLC38A1 solute carrier family 38, member 1 -0.0374776
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0369828
NAP1L1 nucleosome assembly protein 1-like 1 -0.0368683
STC1 stanniocalcin 1 -0.0361338
RPL35A ribosomal protein L35a -0.0361142
WSB1 WD repeat and SOCS box containing 1 -0.0346343
RPLP1 ribosomal protein, large, P1 -0.0344622
RPLP2 ribosomal protein, large, P2 -0.033561
SFRP1 secreted frizzled-related protein 1 -0.0334217
GNAS GNAS complex locus -0.0329388
RAI14 retinoic acid induced 14 -0.0325658
CTSD cathepsin D -0.0315426
RPS24 ribosomal protein S24 -0.0313808
PTMA prothymosin, alpha -0.0307288
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0303616
HLA-E major histocompatibility complex, class I, E -0.030284
IFI16 interferon, gamma-inducible protein 16 -0.030099
CLMP CXADR-like membrane protein -0.0299228
LOX lysyl oxidase -0.0297957
IFITM3 interferon induced transmembrane protein 3 -0.029689
SQSTM1 sequestosome 1 -0.029344
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0291091
SAMD3 sterile alpha motif domain containing 3 -0.0288721
RAB7A RAB7A, member RAS oncogene family -0.0288656
RPL37A ribosomal protein L37a -0.0286399
EIF1 eukaryotic translation initiation factor 1 -0.0282924
RPS3 ribosomal protein S3 -0.02752
CD44 CD44 molecule (Indian blood group) -0.0272107
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0271166
RPS13 ribosomal protein S13 -0.0267857
RPL12 ribosomal protein L12 -0.0266203
PLIN2 perilipin 2 -0.0262208
TMEM132D transmembrane protein 132D -0.0261517
ARL4C ADP-ribosylation factor-like 4C -0.0260441
LOC102724023 ES1 protein homolog, mitochondrial -0.0258219
CAVIN1 caveolae associated protein 1 -0.0255845
ACTG1 actin gamma 1 -0.0254577
COL1A1 collagen, type I, alpha 1 -0.0252539
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0249036
DIAPH2 diaphanous-related formin 2 -0.0248044
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0246319
MMP12 matrix metallopeptidase 12 -0.0245642
TCEAL9 transcription elongation factor A like 9 -0.0240735
RPL37 ribosomal protein L37 -0.0239752
RPS19 ribosomal protein S19 -0.0237683
CANX calnexin -0.0236797
RPL31 ribosomal protein L31 -0.0236726
RPL7A ribosomal protein L7a -0.0234884
RPS27A ribosomal protein S27a -0.023205
RACK1 receptor for activated C kinase 1 -0.0227105
GDF15 growth differentiation factor 15 -0.0227001
RPL9 ribosomal protein L9 -0.0226669
RPL34 ribosomal protein L34 -0.022581
RPL23 ribosomal protein L23 -0.0222935
EFNA5 ephrin-A5 -0.0221854
EGR1 early growth response 1 -0.0220606
NRN1 neuritin 1 -0.0218136
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0212449
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0211836
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0211627
FRMPD4 FERM and PDZ domain containing 4 -0.0209378
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0207735
RND3 Rho family GTPase 3 -0.0206953
RPL38 ribosomal protein L38 -0.0199483
TBCA tubulin folding cofactor A -0.0199041
RPL36A ribosomal protein L36a -0.0198917
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0197782
RPL26 ribosomal protein L26 -0.0195797
VDAC1 voltage-dependent anion channel 1 -0.0194849
ZBTB20 zinc finger and BTB domain containing 20 -0.0194572
INHBA inhibin, beta A -0.0192513
RPS29 ribosomal protein S29 -0.0190984
AFF3 AF4/FMR2 family, member 3 -0.0189007