Rutin (trihydrate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.105778
SOD2 superoxide dismutase 2, mitochondrial 0.0946798
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0940245
CXCL8 chemokine (C-X-C motif) ligand 8 0.0852606
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0767917
NDRG1 N-myc downstream regulated 1 0.07333
FNDC3B fibronectin type III domain containing 3B 0.0721885
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0664862
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0644222
CD109 CD109 molecule 0.0628992
FLNA filamin A, alpha 0.0608102
TRIO trio Rho guanine nucleotide exchange factor 0.0559836
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0544036
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0541916
APLP2 amyloid beta (A4) precursor-like protein 2 0.0539543
FAT1 FAT atypical cadherin 1 0.0519783
STC2 stanniocalcin 2 0.0519332
SUCO SUN domain containing ossification factor 0.0499967
LOXL2 lysyl oxidase-like 2 0.0497844
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0492819
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0487927
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0478792
SMAD3 SMAD family member 3 0.0474539
SHB Src homology 2 domain containing adaptor protein B 0.0453079
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.044352
VEGFA vascular endothelial growth factor A 0.0424498
AFDN afadin, adherens junction formation factor 0.041655
FAM13A family with sequence similarity 13, member A 0.0401358
TPM3 tropomyosin 3 0.0390656
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0384549
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0384483
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0367676
ARRDC3 arrestin domain containing 3 0.0366765
ZMIZ1 zinc finger, MIZ-type containing 1 0.0364031
DDIT4 DNA-damage-inducible transcript 4 0.0357692
GRB10 growth factor receptor-bound protein 10 0.0357486
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0354409
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0354313
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0351
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0346334
NAMPT nicotinamide phosphoribosyltransferase 0.0342528
CTBP2 C-terminal binding protein 2 0.0339735
RNF145 ring finger protein 145 0.0335147
KMT2C lysine (K)-specific methyltransferase 2C 0.0333424
NUP58 nucleoporin 58 0.0332732
MCL1 myeloid cell leukemia 1 0.0331896
ESYT2 extended synaptotagmin-like protein 2 0.032054
ANXA5 annexin A5 0.031168
ZNF292 zinc finger protein 292 0.030331
PLEC plectin 0.0299603
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.029926
CCNL1 cyclin L1 0.0296155
PRPF8 pre-mRNA processing factor 8 0.0293009
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.028937
TNIP1 TNFAIP3 interacting protein 1 0.0286594
SEC23A Sec23 homolog A (S. cerevisiae) 0.0282945
GPC6 glypican 6 0.0276833
HDGF hepatoma-derived growth factor 0.0272974
SETD5 SET domain containing 5 0.02724
HYOU1 hypoxia up-regulated 1 0.0272369
CAMTA1 calmodulin binding transcription activator 1 0.0271109
KDM6A lysine (K)-specific demethylase 6A 0.0269897
ADAM17 ADAM metallopeptidase domain 17 0.0268613
FLNB filamin B, beta 0.0267685
PLIN2 perilipin 2 0.0262628
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0258479
UBA6 ubiquitin-like modifier activating enzyme 6 0.0255232
ERRFI1 ERBB receptor feedback inhibitor 1 0.0250393
ACTN4 actinin, alpha 4 0.0249653
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0248743
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.024806
PICALM phosphatidylinositol binding clathrin assembly protein 0.0246959
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0245191
BIRC6 baculoviral IAP repeat containing 6 0.0241769
RAB8B RAB8B, member RAS oncogene family 0.0240268
FOSL2 FOS-like antigen 2 0.023794
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0237554
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0237431
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0236344
PRELID2 PRELI domain containing 2 0.0236179
WAC WW domain containing adaptor with coiled-coil 0.0235842
XPO1 exportin 1 0.0235211
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0233605
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0233157
HELZ helicase with zinc finger 0.0228511
AHR aryl hydrocarbon receptor 0.0225419
MACF1 microtubule-actin crosslinking factor 1 0.0225242
FAM219A family with sequence similarity 219, member A 0.0223405
AKAP13 A kinase (PRKA) anchor protein 13 0.0222785
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0220932
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0218671
ZSWIM6 zinc finger, SWIM-type containing 6 0.021701
ANLN anillin, actin binding protein 0.0216445
PTK2 protein tyrosine kinase 2 0.0215736
CORO1C coronin, actin binding protein, 1C 0.0215604
APP amyloid beta (A4) precursor protein 0.0214411
COPA coatomer protein complex, subunit alpha 0.0211616
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.02115
NFE2L1 nuclear factor, erythroid 2-like 1 0.0208216
DOCK5 dedicator of cytokinesis 5 0.0207752

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.293074
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.241005
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.176711
MT2A metallothionein 2A -0.126565
SQSTM1 sequestosome 1 -0.117844
NRG1 neuregulin 1 -0.109259
HLA-B major histocompatibility complex, class I, B -0.104726
FTL ferritin, light polypeptide -0.0950542
IFI27 interferon, alpha-inducible protein 27 -0.0804019
ITGA1 integrin, alpha 1 -0.0797187
TMEM156 transmembrane protein 156 -0.0776657
TMSB10 thymosin beta 10 -0.0763451
GLIS3 GLIS family zinc finger 3 -0.0692035
SYT1 synaptotagmin I -0.0644623
HMGA2 high mobility group AT-hook 2 -0.0605768
TPT1 tumor protein, translationally-controlled 1 -0.0576928
RPL35A ribosomal protein L35a -0.0565365
ETV1 ets variant 1 -0.0549263
NRP1 neuropilin 1 -0.0545512
OSMR oncostatin M receptor -0.0524894
S100A6 S100 calcium binding protein A6 -0.0512127
RPS6 ribosomal protein S6 -0.0479058
FOXP1 forkhead box P1 -0.045523
ASPH aspartate beta-hydroxylase -0.0447431
KLHL5 kelch-like family member 5 -0.0436577
IFI16 interferon, gamma-inducible protein 16 -0.0422969
RPS21 ribosomal protein S21 -0.0407963
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0407789
RPLP1 ribosomal protein, large, P1 -0.0398406
RPS24 ribosomal protein S24 -0.0397023
RPL9 ribosomal protein L9 -0.0396053
RPL31 ribosomal protein L31 -0.0387345
GNAS GNAS complex locus -0.0385334
RPL34 ribosomal protein L34 -0.0384886
IER3 immediate early response 3 -0.0383672
RPL23 ribosomal protein L23 -0.0375201
WSB1 WD repeat and SOCS box containing 1 -0.0370163
RPL26 ribosomal protein L26 -0.0365185
RPL38 ribosomal protein L38 -0.036377
RACK1 receptor for activated C kinase 1 -0.0361651
RPL12 ribosomal protein L12 -0.0360208
PTMA prothymosin, alpha -0.0357596
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0355956
S100A9 S100 calcium binding protein A9 -0.0350388
RPS19 ribosomal protein S19 -0.0336161
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.033452
RPS5 ribosomal protein S5 -0.0318264
RPL28 ribosomal protein L28 -0.0311537
BICD1 bicaudal D homolog 1 (Drosophila) -0.0308351
RPS27A ribosomal protein S27a -0.0305195
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0305181
FTH1 ferritin, heavy polypeptide 1 -0.0302348
B2M beta-2-microglobulin -0.0296946
RPL37 ribosomal protein L37 -0.0292378
RIGI RNA sensor RIG-I -0.0290559
RPS29 ribosomal protein S29 -0.0288333
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0287259
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0286128
FN1 fibronectin 1 -0.0279745
TXNRD1 thioredoxin reductase 1 -0.027917
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0277172
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0274221
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0272868
LOC102724023 ES1 protein homolog, mitochondrial -0.0269833
LY6E lymphocyte antigen 6 complex, locus E -0.0264128
SOX4 SRY (sex determining region Y)-box 4 -0.0263209
RPS8 ribosomal protein S8 -0.0257042
IFI6 interferon, alpha-inducible protein 6 -0.0254796
ACTG1 actin gamma 1 -0.0254347
RPL37A ribosomal protein L37a -0.0253293
MCTP2 multiple C2 domains, transmembrane 2 -0.0252929
MAP1B microtubule-associated protein 1B -0.0247145
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.024341
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0243121
LOC112694756 uncharaterized LOC112694756 -0.0236749
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0236033
RANBP17 RAN binding protein 17 -0.0232572
RPS28 ribosomal protein S28 -0.0232118
DNAH5 dynein, axonemal, heavy chain 5 -0.0230565
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0230325
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0228285
MGST1 microsomal glutathione S-transferase 1 -0.022396
CD63 CD63 molecule -0.0222659
HMGB1 high mobility group box 1 -0.0222413
EIF1 eukaryotic translation initiation factor 1 -0.0221418
BASP1 brain abundant, membrane attached signal protein 1 -0.0217828
NCOA7 nuclear receptor coactivator 7 -0.0216861
NAP1L1 nucleosome assembly protein 1-like 1 -0.0216225
RPLP0 ribosomal protein, large, P0 -0.0215891
SMIM14 small integral membrane protein 14 -0.0214452
SEC61G Sec61 gamma subunit -0.0212758
RPS12 ribosomal protein S12 -0.0212614
RPL36 ribosomal protein L36 -0.0211116
RPS20 ribosomal protein S20 -0.0208781
RPL8 ribosomal protein L8 -0.0207384
BPTF bromodomain PHD finger transcription factor -0.0207376
RPS15 ribosomal protein S15 -0.0205636
RPLP2 ribosomal protein, large, P2 -0.0204308
TMEM263 transmembrane protein 263 -0.0203238
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0202288