Rutin (trihydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.108531
PDE4B phosphodiesterase 4B, cAMP-specific 0.0854217
LMO7 LIM domain 7 0.0851208
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0824312
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0806705
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0786163
PLAUR plasminogen activator, urokinase receptor 0.0771117
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0762805
FERMT1 fermitin family member 1 0.0728294
ITPRID2 ITPR interacting domain containing 2 0.0712427
DSPP dentin sialophosphoprotein 0.07055
LAMC2 laminin, gamma 2 0.0664357
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0662564
EGFR epidermal growth factor receptor 0.0657871
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0630683
TXNRD1 thioredoxin reductase 1 0.062903
FAT1 FAT atypical cadherin 1 0.0548318
EPHA2 EPH receptor A2 0.0535239
NDRG1 N-myc downstream regulated 1 0.0534697
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.051188
KMT2C lysine (K)-specific methyltransferase 2C 0.0497952
RAB10 RAB10, member RAS oncogene family 0.0490388
MYO5B myosin VB 0.0489042
AXIN2 axin 2 0.0473845
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0472031
RUNX2 runt-related transcription factor 2 0.0466347
EREG epiregulin 0.0466046
EZR ezrin 0.046355
RPL3 ribosomal protein L3 0.0463334
TOP1 topoisomerase (DNA) I 0.0461094
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0460637
OXR1 oxidation resistance 1 0.0459217
ZNRF3 zinc and ring finger 3 0.0456484
LAMB3 laminin, beta 3 0.0451617
MYH9 myosin, heavy chain 9, non-muscle 0.0445587
ACTN4 actinin, alpha 4 0.0436486
GSK3B glycogen synthase kinase 3 beta 0.0435443
MACF1 microtubule-actin crosslinking factor 1 0.0433983
KDM6A lysine (K)-specific demethylase 6A 0.0430943
DSCAM Down syndrome cell adhesion molecule 0.0428954
NIBAN2 niban apoptosis regulator 2 0.0428733
CD9 CD9 molecule 0.0419364
HSPA8 heat shock 70kDa protein 8 0.0413257
PCBP2 poly(rC) binding protein 2 0.0411987
ITGA6 integrin, alpha 6 0.0409888
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0409022
ZNF292 zinc finger protein 292 0.0402698
ANKRD11 ankyrin repeat domain 11 0.0400129
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0397161
SNX9 sorting nexin 9 0.0388883
ANXA11 annexin A11 0.0388658
EEF2 eukaryotic translation elongation factor 2 0.0385797
SEPTIN9 septin 9 0.0381283
NUP58 nucleoporin 58 0.0376042
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0374524
ESRP1 epithelial splicing regulatory protein 1 0.0364655
WAC WW domain containing adaptor with coiled-coil 0.036005
AREG amphiregulin 0.0359735
YAP1 Yes-associated protein 1 0.0357288
ESYT2 extended synaptotagmin-like protein 2 0.0351703
CTSB cathepsin B 0.0350106
SFPQ splicing factor proline/glutamine-rich 0.0349893
RNF43 ring finger protein 43 0.0347041
FLNA filamin A, alpha 0.0344644
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0340378
ATXN1 ataxin 1 0.0335163
PFKP phosphofructokinase, platelet 0.0333837
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0333824
RREB1 ras responsive element binding protein 1 0.0328596
NCKAP1 NCK-associated protein 1 0.0328189
ARRDC3 arrestin domain containing 3 0.032813
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0317272
RANBP9 RAN binding protein 9 0.0315158
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0307077
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0302572
NAV2 neuron navigator 2 0.0299949
ZFAND3 zinc finger, AN1-type domain 3 0.0296915
MKI67 marker of proliferation Ki-67 0.0293621
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0292973
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0283633
GCLC glutamate-cysteine ligase, catalytic subunit 0.0282418
MED13L mediator complex subunit 13-like 0.0282194
GOLGA4 golgin A4 0.0281688
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.028084
CENPF centromere protein F, 350/400kDa 0.0278921
TSC22D2 TSC22 domain family, member 2 0.0278664
BCL2L1 BCL2-like 1 0.0271558
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0270145
RBM39 RNA binding motif protein 39 0.0269612
EIF4B eukaryotic translation initiation factor 4B 0.026523
FAR1 fatty acyl CoA reductase 1 0.0261669
IPO7 importin 7 0.0260556
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0259539
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0258582
ARHGAP32 Rho GTPase activating protein 32 0.0257026
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0256846
KIAA0040 KIAA0040 0.0256756
CCNL1 cyclin L1 0.0255511
UBA6 ubiquitin-like modifier activating enzyme 6 0.0255036
EWSR1 EWS RNA-binding protein 1 0.0252018

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.0751142
TMSB10 thymosin beta 10 -0.0656408
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.054039
RPS6 ribosomal protein S6 -0.0536174
PTMA prothymosin, alpha -0.0473842
VCL vinculin -0.0468801
FRAS1 Fraser extracellular matrix complex subunit 1 -0.042955
RPLP1 ribosomal protein, large, P1 -0.0388485
GPC5 glypican 5 -0.0384825
RPL35A ribosomal protein L35a -0.038435
RPS8 ribosomal protein S8 -0.0377425
HMGA2 high mobility group AT-hook 2 -0.0345449
FHIT fragile histidine triad -0.0334866
RPS24 ribosomal protein S24 -0.0326884
EMP1 epithelial membrane protein 1 -0.0309089
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0308385
RPS3 ribosomal protein S3 -0.0304021
RPL34 ribosomal protein L34 -0.0301153
RPLP0 ribosomal protein, large, P0 -0.0292018
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0286335
CDK13 cyclin-dependent kinase 13 -0.0277201
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0266583
RPS19 ribosomal protein S19 -0.0264738
RPS29 ribosomal protein S29 -0.0264223
TPT1 tumor protein, translationally-controlled 1 -0.0256791
RPL36 ribosomal protein L36 -0.0254417
CREB5 cAMP responsive element binding protein 5 -0.0245772
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0243496
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.024138
IER3 immediate early response 3 -0.0239178
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0234845
SQSTM1 sequestosome 1 -0.0228885
RPL37A ribosomal protein L37a -0.0225429
RPL31 ribosomal protein L31 -0.0223685
ANKRD17 ankyrin repeat domain 17 -0.0218898
RPS5 ribosomal protein S5 -0.0217444
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0216708
RPS13 ribosomal protein S13 -0.0212419
IARS1 isoleucyl-tRNA synthetase 1 -0.0211115
RACK1 receptor for activated C kinase 1 -0.0204598
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0202157
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0201857
RPLP2 ribosomal protein, large, P2 -0.0200177
RPL35 ribosomal protein L35 -0.0198896
CUX1 cut-like homeobox 1 -0.0197048
UBAP2 ubiquitin associated protein 2 -0.019541
CDHR3 cadherin-related family member 3 -0.0194108
AKAP9 A kinase (PRKA) anchor protein 9 -0.0190871
RPL12 ribosomal protein L12 -0.0189736
KLF5 Kruppel-like factor 5 (intestinal) -0.0188722
PDLIM5 PDZ and LIM domain 5 -0.0188577
RPL23 ribosomal protein L23 -0.0188084
S100A9 S100 calcium binding protein A9 -0.0186544
TTC3 tetratricopeptide repeat domain 3 -0.0184124
MT1X metallothionein 1X -0.0183169
FTL ferritin, light polypeptide -0.0179885
RPS16 ribosomal protein S16 -0.0173841
EGR1 early growth response 1 -0.0173738
TAS2R14 taste receptor, type 2, member 14 -0.0170418
MTAP methylthioadenosine phosphorylase -0.0170133
CHRM3 cholinergic receptor, muscarinic 3 -0.0166375
RPS28 ribosomal protein S28 -0.016591
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.016573
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0165504
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.016147
HOMER1 homer scaffolding protein 1 -0.0161266
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0160582
NPR2 natriuretic peptide receptor 2 -0.0159157
GLCCI1 glucocorticoid induced 1 -0.0158585
RPL26 ribosomal protein L26 -0.015788
RSU1 Ras suppressor protein 1 -0.0156065
RPS15 ribosomal protein S15 -0.0152363
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0152099
CMIP c-Maf inducing protein -0.015173
PERP PERP, TP53 apoptosis effector -0.0151179
PHF14 PHD finger protein 14 -0.015102
RPL13A ribosomal protein L13a -0.0148656
ANXA1 annexin A1 -0.0144455
RPS25 ribosomal protein S25 -0.0144337
DOCK5 dedicator of cytokinesis 5 -0.0143218
RPL32 ribosomal protein L32 -0.0141265
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0139588
NABP1 nucleic acid binding protein 1 -0.0138892
RPL9 ribosomal protein L9 -0.0136709
INTS6 integrator complex subunit 6 -0.0135598
RTN3 reticulon 3 -0.013541
MTDH metadherin -0.0134764
EIF5B eukaryotic translation initiation factor 5B -0.0133357
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0132978
TRAP1 TNF receptor-associated protein 1 -0.0132749
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.013206
RPL6 ribosomal protein L6 -0.0131111
DSTN destrin (actin depolymerizing factor) -0.0129142
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -0.0128597
ARF1 ADP-ribosylation factor 1 -0.0128449
MRPS6 mitochondrial ribosomal protein S6 -0.0128166
PCNX4 pecanex 4 -0.0126744
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0126165
DYM dymeclin -0.0125678
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0125502