Rutin (trihydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.132432
MYH9 myosin, heavy chain 9, non-muscle 0.122726
NAV2 neuron navigator 2 0.119588
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.103588
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.103326
PCBP2 poly(rC) binding protein 2 0.102612
AKAP12 A kinase (PRKA) anchor protein 12 0.100965
PLEC plectin 0.100559
KRT18 keratin 18, type I 0.0945326
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0909922
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0884154
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0878097
ESYT2 extended synaptotagmin-like protein 2 0.08672
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.085819
ITGA6 integrin, alpha 6 0.0812726
EZR ezrin 0.080474
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0803227
MACF1 microtubule-actin crosslinking factor 1 0.077968
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0758492
PDGFA platelet-derived growth factor alpha polypeptide 0.0750809
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0740395
EEF2 eukaryotic translation elongation factor 2 0.0729925
FLNB filamin B, beta 0.072834
NKD1 naked cuticle homolog 1 (Drosophila) 0.0682994
ARGLU1 arginine and glutamate rich 1 0.0674729
MSN moesin 0.0673916
SEPTIN9 septin 9 0.0671675
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0666627
ITPRID2 ITPR interacting domain containing 2 0.0659014
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.062332
HDAC4 histone deacetylase 4 0.061201
ACTN4 actinin, alpha 4 0.059265
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0585365
ETNK1 ethanolamine kinase 1 0.058115
UBA6 ubiquitin-like modifier activating enzyme 6 0.0520278
DSPP dentin sialophosphoprotein 0.051593
ANLN anillin, actin binding protein 0.051294
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0506237
ANO1 anoctamin 1, calcium activated chloride channel 0.0505152
CDH13 cadherin 13 0.0497745
ASPH aspartate beta-hydroxylase 0.0493364
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0486908
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0481608
SETD5 SET domain containing 5 0.04803
CMIP c-Maf inducing protein 0.0479124
ITGB4 integrin, beta 4 0.0478002
EEF1G eukaryotic translation elongation factor 1 gamma 0.0474858
FLNA filamin A, alpha 0.0471861
BIRC6 baculoviral IAP repeat containing 6 0.0457802
DST dystonin 0.0453813
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0437047
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0428568
KDM6A lysine (K)-specific demethylase 6A 0.0422866
TPM3 tropomyosin 3 0.0417894
MAML2 mastermind-like 2 (Drosophila) 0.0415229
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0413345
KMT2C lysine (K)-specific methyltransferase 2C 0.0410647
LDHA lactate dehydrogenase A 0.0405507
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0396269
ABHD2 abhydrolase domain containing 2 0.0395603
WAC WW domain containing adaptor with coiled-coil 0.0393282
ENO1 enolase 1, (alpha) 0.0392277
PGK1 phosphoglycerate kinase 1 0.0391575
ERRFI1 ERBB receptor feedback inhibitor 1 0.0391111
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.038901
NDRG1 N-myc downstream regulated 1 0.0382662
ACTN1 actinin, alpha 1 0.03825
KMT2E lysine (K)-specific methyltransferase 2E 0.0380177
NUMA1 nuclear mitotic apparatus protein 1 0.0373621
RPL3 ribosomal protein L3 0.0372012
PICALM phosphatidylinositol binding clathrin assembly protein 0.0366838
PRPF8 pre-mRNA processing factor 8 0.0363652
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0363473
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0356012
EIF4B eukaryotic translation initiation factor 4B 0.0354364
ATXN1 ataxin 1 0.0353729
TRIO trio Rho guanine nucleotide exchange factor 0.0353671
RBM26 RNA binding motif protein 26 0.0351066
DDIT4 DNA-damage-inducible transcript 4 0.034823
ADAM17 ADAM metallopeptidase domain 17 0.0346446
MCL1 myeloid cell leukemia 1 0.0345142
USP34 ubiquitin specific peptidase 34 0.0342906
BHLHE40 basic helix-loop-helix family, member e40 0.0341899
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0341686
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0336389
SBF2 SET binding factor 2 0.0334017
USP9X ubiquitin specific peptidase 9, X-linked 0.0333563
TMF1 TATA element modulatory factor 1 0.0332572
CEMIP cell migration inducing protein, hyaluronan binding 0.0331286
TNIK TRAF2 and NCK interacting kinase 0.0329764
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.032641
VMP1 vacuole membrane protein 1 0.0324576
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0321216
EFNB2 ephrin-B2 0.0319427
DSCAM Down syndrome cell adhesion molecule 0.0316783
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0316101
RCOR1 REST corepressor 1 0.031538
TM9SF2 transmembrane 9 superfamily member 2 0.0315158
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0314771
AKAP13 A kinase (PRKA) anchor protein 13 0.0310671

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.129362
TPT1 tumor protein, translationally-controlled 1 -0.115273
RPS6 ribosomal protein S6 -0.0953361
RPL35A ribosomal protein L35a -0.0917105
RPS24 ribosomal protein S24 -0.0650534
RPLP1 ribosomal protein, large, P1 -0.0623145
TMSB10 thymosin beta 10 -0.0600987
PTMA prothymosin, alpha -0.0565771
ACTG1 actin gamma 1 -0.0520473
RPS8 ribosomal protein S8 -0.0515814
RPLP2 ribosomal protein, large, P2 -0.0484034
RPS19 ribosomal protein S19 -0.046684
HMGB1 high mobility group box 1 -0.0442071
RPS21 ribosomal protein S21 -0.043746
RPL23 ribosomal protein L23 -0.0425201
RPS27A ribosomal protein S27a -0.0418093
RPLP0 ribosomal protein, large, P0 -0.0409215
RPL38 ribosomal protein L38 -0.0384225
RPL34 ribosomal protein L34 -0.0371387
RPL26 ribosomal protein L26 -0.0369998
SYT1 synaptotagmin I -0.0330171
RPS16 ribosomal protein S16 -0.0329257
RPL12 ribosomal protein L12 -0.0327275
MT2A metallothionein 2A -0.0326581
RPL37A ribosomal protein L37a -0.0321947
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0314007
RPL9 ribosomal protein L9 -0.0298607
RPS13 ribosomal protein S13 -0.0294897
FTL ferritin, light polypeptide -0.0293437
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0283251
RPS15 ribosomal protein S15 -0.0282952
RPL31 ribosomal protein L31 -0.0282683
WWOX WW domain containing oxidoreductase -0.0262842
RPL36 ribosomal protein L36 -0.0260949
RACK1 receptor for activated C kinase 1 -0.0252433
GNAS GNAS complex locus -0.0247003
UBB ubiquitin B -0.024138
RPS5 ribosomal protein S5 -0.0236526
NAP1L1 nucleosome assembly protein 1-like 1 -0.0233911
RPL28 ribosomal protein L28 -0.0231825
H3-3B H3.3 histone B -0.0231648
FUS FUS RNA binding protein -0.0228047
SYK spleen tyrosine kinase -0.0227163
S100A9 S100 calcium binding protein A9 -0.0227097
RPL32 ribosomal protein L32 -0.0225969
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0225828
RPL36A ribosomal protein L36a -0.0221372
IER3 immediate early response 3 -0.0220702
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0219382
RPL35 ribosomal protein L35 -0.0215919
FOXP1 forkhead box P1 -0.0215077
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0212629
LOC102724023 ES1 protein homolog, mitochondrial -0.0208679
RPL5 ribosomal protein L5 -0.0207313
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0206981
RPS3 ribosomal protein S3 -0.0206855
RPL27A ribosomal protein L27a -0.0201716
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0201716
RPL8 ribosomal protein L8 -0.0201542
DEK DEK proto-oncogene -0.0200267
SOX4 SRY (sex determining region Y)-box 4 -0.0199043
RPS14 ribosomal protein S14 -0.0195794
EIF1 eukaryotic translation initiation factor 1 -0.01956
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0195164
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0191371
RPL11 ribosomal protein L11 -0.0190034
BMP5 bone morphogenetic protein 5 -0.0189789
RPS29 ribosomal protein S29 -0.0188625
RPL18 ribosomal protein L18 -0.0186007
RPL6 ribosomal protein L6 -0.01856
H1-0 H1.0 linker histone -0.0185046
RPL37 ribosomal protein L37 -0.0184153
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0180998
RPS20 ribosomal protein S20 -0.0178728
PDE4D phosphodiesterase 4D, cAMP-specific -0.0178587
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0178059
CCND1 cyclin D1 -0.0175643
KPNB1 karyopherin (importin) beta 1 -0.0175137
TRIM56 tripartite motif containing 56 -0.0174512
VDAC1 voltage-dependent anion channel 1 -0.0174211
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.01715
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0167776
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0166768
MTAP methylthioadenosine phosphorylase -0.016657
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0166184
NPR2 natriuretic peptide receptor 2 -0.0163843
GPHN gephyrin -0.0163725
SMYD3 SET and MYND domain containing 3 -0.0163063
ATP5F1E ATP synthase F1 subunit epsilon -0.016131
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0161203
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0157969
BPTF bromodomain PHD finger transcription factor -0.015777
RHOBTB3 Rho-related BTB domain containing 3 -0.0156992
RPL7A ribosomal protein L7a -0.0156565
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0156298
PCLO piccolo presynaptic cytomatrix protein -0.0155315
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0155234
SEC61G Sec61 gamma subunit -0.0151242
TM4SF1 transmembrane 4 L six family member 1 -0.0151135
RSL1D1 ribosomal L1 domain containing 1 -0.0149068