Rutin (trihydrate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rutin (trihydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rutin (trihydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.109363
SOD2 superoxide dismutase 2, mitochondrial 0.0993101
COL6A3 collagen, type VI, alpha 3 0.0758134
FNDC3B fibronectin type III domain containing 3B 0.0543006
LOXL2 lysyl oxidase-like 2 0.0416149
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0400643
ELL2 elongation factor, RNA polymerase II, 2 0.0398094
SMAD3 SMAD family member 3 0.0364256
JARID2 jumonji, AT rich interactive domain 2 0.0357426
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0327763
NAV2 neuron navigator 2 0.0309937
TRIO trio Rho guanine nucleotide exchange factor 0.0284997
PDE4D phosphodiesterase 4D, cAMP-specific 0.026915
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0269039
NAMPT nicotinamide phosphoribosyltransferase 0.0268206
ARHGAP21 Rho GTPase activating protein 21 0.0264659
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0255926
SEPTIN9 septin 9 0.0242562
PALM2AKAP2 PALM2 and AKAP2 fusion 0.023885
ATP13A3 ATPase type 13A3 0.0232877
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0232323
DSCAM Down syndrome cell adhesion molecule 0.0231419
SPAG9 sperm associated antigen 9 0.0222909
APOLD1 apolipoprotein L domain containing 1 0.0221535
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0219271
PDE8A phosphodiesterase 8A 0.0217244
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0215525
AMPD3 adenosine monophosphate deaminase 3 0.0211846
CLTC clathrin, heavy chain (Hc) 0.020678
APAF1 apoptotic peptidase activating factor 1 0.0205988
FLNA filamin A, alpha 0.0204753
FAM13A family with sequence similarity 13, member A 0.0203377
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0202216
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0201797
FN1 fibronectin 1 0.0192446
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0177595
RUNX1 runt-related transcription factor 1 0.0177226
CAMTA1 calmodulin binding transcription activator 1 0.0173709
MSI2 musashi RNA-binding protein 2 0.0170482
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0167701
MYOF myoferlin 0.0167063
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0164471
HSPA8 heat shock 70kDa protein 8 0.0163053
COG6 component of oligomeric golgi complex 6 0.0162785
HDLBP high density lipoprotein binding protein 0.0162298
G0S2 G0/G1 switch 2 0.0158444
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0158379
MSN moesin 0.0157115
PLEC plectin 0.0155848
CHD1 chromodomain helicase DNA binding protein 1 0.0155243
DST dystonin 0.0150351
PLPP3 phospholipid phosphatase 3 0.014905
BIRC6 baculoviral IAP repeat containing 6 0.0147082
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0146025
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0145719
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0144852
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0144056
CEP192 centrosomal protein 192kDa 0.0143371
NBAS neuroblastoma amplified sequence 0.0140987
OGA O-GlcNAcase 0.014023
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0133828
EPAS1 endothelial PAS domain protein 1 0.0130425
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0130152
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0129774
BHLHE40 basic helix-loop-helix family, member e40 0.0128607
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0127706
NGLY1 N-glycanase 1 0.0127234
KIAA1217 KIAA1217 0.012676
EGFR epidermal growth factor receptor 0.0124942
TM9SF2 transmembrane 9 superfamily member 2 0.0124862
TNPO1 transportin 1 0.0124318
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0123362
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0121997
OSBPL3 oxysterol binding protein-like 3 0.0121827
RPL3 ribosomal protein L3 0.0121626
ARRDC3 arrestin domain containing 3 0.0121036
RNF213 ring finger protein 213 0.0119813
USP9X ubiquitin specific peptidase 9, X-linked 0.0118624
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0118426
COL4A2 collagen, type IV, alpha 2 0.0118239
CDK17 cyclin-dependent kinase 17 0.0118106
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0117808
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0117068
APP amyloid beta (A4) precursor protein 0.0116916
RNF19B ring finger protein 19B 0.0116401
CLIP2 CAP-GLY domain containing linker protein 2 0.0115038
GPR107 G protein-coupled receptor 107 0.0114823
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0114683
NCKAP1 NCK-associated protein 1 0.0114203
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0113924
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0113814
KDM3A lysine (K)-specific demethylase 3A 0.0113596
MAP2K1 mitogen-activated protein kinase kinase 1 0.0113553
TNS1 tensin 1 0.0112934
SAR1A secretion associated, Ras related GTPase 1A 0.0112577
NDEL1 nudE neurodevelopment protein 1-like 1 0.011162
TRAM2 translocation associated membrane protein 2 0.0110854
FRMD6 FERM domain containing 6 0.0110787
SMOX spermine oxidase 0.0110761
DSPP dentin sialophosphoprotein 0.0109945

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.240012
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207288
COL1A1 collagen, type I, alpha 1 -0.116914
HLA-B major histocompatibility complex, class I, B -0.114339
TMSB10 thymosin beta 10 -0.113524
AKAP12 A kinase (PRKA) anchor protein 12 -0.105474
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.089907
B2M beta-2-microglobulin -0.0807321
FTL ferritin, light polypeptide -0.0719639
RPS6 ribosomal protein S6 -0.067223
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0650237
ACTG1 actin gamma 1 -0.0639806
NALF1 NALCN channel auxiliary factor 1 -0.0616454
TPT1 tumor protein, translationally-controlled 1 -0.0582341
PRKG1 protein kinase, cGMP-dependent, type I -0.0581737
COL1A2 collagen, type I, alpha 2 -0.0572861
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0563942
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0513407
RPLP1 ribosomal protein, large, P1 -0.0512611
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0506935
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0500574
MT2A metallothionein 2A -0.0494793
TPM4 tropomyosin 4 -0.043787
COL6A1 collagen, type VI, alpha 1 -0.0415057
STC1 stanniocalcin 1 -0.0410419
RPS8 ribosomal protein S8 -0.0404338
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0399708
EIF1 eukaryotic translation initiation factor 1 -0.03987
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0398435
RPL35A ribosomal protein L35a -0.0387235
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0384407
POTEF POTE ankyrin domain family, member F -0.0381256
RPS19 ribosomal protein S19 -0.035662
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0355459
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0346568
CDH13 cadherin 13 -0.0345969
CLMP CXADR-like membrane protein -0.0332363
EMP1 epithelial membrane protein 1 -0.0331232
RPL34 ribosomal protein L34 -0.0316247
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0316043
WSB1 WD repeat and SOCS box containing 1 -0.0312431
HLA-A major histocompatibility complex, class I, A -0.0309768
PTMA prothymosin, alpha -0.0300747
OXR1 oxidation resistance 1 -0.0298921
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0295459
PDIA3 protein disulfide isomerase family A, member 3 -0.0282012
S100A9 S100 calcium binding protein A9 -0.0281567
RPL37A ribosomal protein L37a -0.0273732
RPL28 ribosomal protein L28 -0.0271306
RPL23 ribosomal protein L23 -0.0268544
MYO10 myosin X -0.0266835
ADM adrenomedullin -0.0265662
HMGA2 high mobility group AT-hook 2 -0.0260875
RPL9 ribosomal protein L9 -0.0257764
PFN1 profilin 1 -0.0256349
RPL31 ribosomal protein L31 -0.0255397
KTN1 kinectin 1 (kinesin receptor) -0.0250485
RPLP2 ribosomal protein, large, P2 -0.0249621
PKM pyruvate kinase, muscle -0.0246913
S100A6 S100 calcium binding protein A6 -0.0243197
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0240213
RPL12 ribosomal protein L12 -0.0239741
MMP1 matrix metallopeptidase 1 -0.0237086
RPS13 ribosomal protein S13 -0.0237027
NPTX1 neuronal pentraxin I -0.0234427
TGFBI transforming growth factor, beta-induced, 68kDa -0.0234176
KIAA1549L KIAA1549-like -0.0231451
COL6A2 collagen, type VI, alpha 2 -0.0230317
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0226724
RPS14 ribosomal protein S14 -0.0222578
RPS12 ribosomal protein S12 -0.0222283
GREM1 gremlin 1, DAN family BMP antagonist -0.0220608
CALR calreticulin -0.0212568
PRRX1 paired related homeobox 1 -0.0211363
HILPDA hypoxia inducible lipid droplet-associated -0.0209571
TFPI2 tissue factor pathway inhibitor 2 -0.0209419
RPS3 ribosomal protein S3 -0.020708
MYADM myeloid-associated differentiation marker -0.0207001
FRMD4A FERM domain containing 4A -0.0202776
IGFBP7 insulin-like growth factor binding protein 7 -0.0202511
ALCAM activated leukocyte cell adhesion molecule -0.0200465
LMAN1 lectin, mannose-binding, 1 -0.0198801
LTBP1 latent transforming growth factor beta binding protein 1 -0.0198549
SAMD3 sterile alpha motif domain containing 3 -0.0198368
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0195928
CAVIN1 caveolae associated protein 1 -0.0195633
TM4SF1 transmembrane 4 L six family member 1 -0.0193222
RPS16 ribosomal protein S16 -0.0191991
RPLP0 ribosomal protein, large, P0 -0.0189165
TMEM165 transmembrane protein 165 -0.0189105
CEMIP cell migration inducing protein, hyaluronan binding -0.0188669
FOXP1 forkhead box P1 -0.0187536
RPL11 ribosomal protein L11 -0.0187115
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0186766
RPL26 ribosomal protein L26 -0.0186423
CYB5R3 cytochrome b5 reductase 3 -0.0185419
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0185347
RPL32 ribosomal protein L32 -0.0182254
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0179824
RPL7A ribosomal protein L7a -0.0178854