Ruxolitinib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/25126798
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Genes

198 proteins with high or low expression in Ruxolitinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
FBRSL1 fibrosin-like 1 2.75
CLK1 CDC-like kinase 1 1.26
GNB5 guanine nucleotide binding protein (G protein), beta 5 1.25
CEP290 centrosomal protein 290kDa 1.0
CCNL1 cyclin L1 0.91
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 0.79
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.78
CREBZF CREB/ATF bZIP transcription factor 0.73
RUNX3 runt-related transcription factor 3 0.71
HOOK2 hook microtubule-tethering protein 2 0.7
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.67
OASL 2'-5'-oligoadenylate synthetase-like 0.66
CCNL2 cyclin L2 0.63
DUSP4 dual specificity phosphatase 4 0.61
SERINC5 serine incorporator 5 0.6
KBTBD8 kelch repeat and BTB (POZ) domain containing 8 0.59
NRP1 neuropilin 1 0.58
PLD6 phospholipase D family, member 6 0.57
ACAD11 acyl-CoA dehydrogenase family, member 11 0.56
KMT2B lysine (K)-specific methyltransferase 2B 0.56
PBX3 pre-B-cell leukemia homeobox 3 0.56
ODC1 ornithine decarboxylase 1 0.52
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.52
CBR1 carbonyl reductase 1 0.52
PIP prolactin-induced protein 0.52
FOXC1 forkhead box C1 0.51
DCAF15 DDB1 and CUL4 associated factor 15 0.51
TFCP2L1 transcription factor CP2-like 1 0.51
TEC tec protein tyrosine kinase 0.5
KLF13 Kruppel-like factor 13 0.49
SF1 splicing factor 1 0.49
PEX19 peroxisomal biogenesis factor 19 0.49
ORC1 origin recognition complex, subunit 1 0.48
TBX3 T-box 3 0.48
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.48
HIST2H3A histone cluster 2, H3a 0.48
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein 0.48
SLC45A1 solute carrier family 45, member 1 0.47
C5ORF30 chromosome 5 open reading frame 30 0.46
RANBP6 RAN binding protein 6 0.46
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.46
NDFIP2 Nedd4 family interacting protein 2 0.46
FOXO1 forkhead box O1 0.46
ZNF799 zinc finger protein 799 0.45
DCLRE1C DNA cross-link repair 1C 0.45
GRB7 growth factor receptor-bound protein 7 0.45
ULK1 unc-51 like autophagy activating kinase 1 0.45
RABAC1 Rab acceptor 1 (prenylated) 0.44
APOB apolipoprotein B 0.44
PRELID3B PRELI domain containing 3B 0.44
ERBB3 erb-b2 receptor tyrosine kinase 3 0.43
FAM133B family with sequence similarity 133, member B 0.43
LCORL ligand dependent nuclear receptor corepressor-like 0.43
ZNF503 zinc finger protein 503 0.43
PGRMC1 progesterone receptor membrane component 1 0.43
RPP21 ribonuclease P/MRP 21kDa subunit 0.42
FCF1 FCF1 rRNA-processing protein 0.42
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 0.42
ZNF616 zinc finger protein 616 0.42
CCN2 cellular communication network factor 2 0.41
SNAP91 synaptosomal-associated protein, 91kDa 0.41
CLK3 CDC-like kinase 3 0.41
IQSEC2 IQ motif and Sec7 domain 2 0.41
RBMXL3 RNA binding motif protein, X-linked-like 3 0.41
SAP30BP SAP30 binding protein 0.41
ETV5 ets variant 5 0.41
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.41
PRPF3 pre-mRNA processing factor 3 0.41
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.4
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.4
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.4
GTPBP8 GTP-binding protein 8 (putative) 0.4
TRIM68 tripartite motif containing 68 0.4
MYL9 myosin, light chain 9, regulatory 0.4
JPH1 junctophilin 1 0.39
MTF1 metal-regulatory transcription factor 1 0.39
TMEM242 transmembrane protein 242 0.39
APOE apolipoprotein E 0.39
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.39
GATAD2A GATA zinc finger domain containing 2A 0.39
SMAD9 SMAD family member 9 0.39
SESN2 sestrin 2 0.38
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.38
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.38
DST dystonin 0.38
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 0.38
ONECUT2 one cut homeobox 2 0.38
AKTIP AKT interacting protein 0.38
PLIN2 perilipin 2 0.38
CPN1 carboxypeptidase N, polypeptide 1 0.37
NOTCH3 notch 3 0.37
OTUD3 OTU deubiquitinase 3 0.37
CRY1 cryptochrome circadian clock 1 0.37
RBL2 retinoblastoma-like 2 0.37
CYTH3 cytohesin 3 0.37
PTBP2 polypyrimidine tract binding protein 2 0.37
HOXA7 homeobox A7 0.37
LMBRD1 LMBR1 domain containing 1 0.37
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.37
KIFC3 kinesin family member C3 0.37

low expression

Symbol Name Standardized Value
UNC93B1 unc-93 homolog B1 (C. elegans) -1.29
MLXIPL MLX interacting protein-like -1.05
NR1D1 nuclear receptor subfamily 1, group D, member 1 -1.02
F3 coagulation factor III (thromboplastin, tissue factor) -0.92
MZT2B mitotic spindle organizing protein 2B -0.89
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -0.81
LAMB2 laminin, beta 2 (laminin S) -0.73
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.73
C1ORF43 chromosome 1 open reading frame 43 -0.72
BORCS7 BLOC-1 related complex subunit 7 -0.68
JUN jun proto-oncogene -0.67
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -0.65
CSRP2 cysteine and glycine-rich protein 2 -0.63
DSTYK dual serine/threonine and tyrosine protein kinase -0.62
RND3 Rho family GTPase 3 -0.59
WDR20 WD repeat domain 20 -0.58
KLK6 kallikrein-related peptidase 6 -0.57
ABLIM2 actin binding LIM protein family, member 2 -0.56
POLI polymerase (DNA directed) iota -0.54
RHOBTB3 Rho-related BTB domain containing 3 -0.54
LTBP3 latent transforming growth factor beta binding protein 3 -0.54
SON SON DNA binding protein -0.54
TBC1D30 TBC1 domain family, member 30 -0.53
ZFYVE19 zinc finger, FYVE domain containing 19 -0.53
CCDC90B coiled-coil domain containing 90B -0.53
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -0.53
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 -0.53
TRAF4 TNF receptor-associated factor 4 -0.52
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.52
FCSK fucose kinase -0.52
PAWR PRKC, apoptosis, WT1, regulator -0.51
CUEDC1 CUE domain containing 1 -0.51
TRABD TraB domain containing -0.51
E2F2 E2F transcription factor 2 -0.5
BMT2 base methyltransferase of 25S rRNA 2 homolog -0.5
UNC13D unc-13 homolog D (C. elegans) -0.49
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.49
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.49
RPLP1 ribosomal protein, large, P1 -0.49
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -0.49
SAPCD2 suppressor APC domain containing 2 -0.48
C6ORF62 chromosome 6 open reading frame 62 -0.48
ARHGAP23 Rho GTPase activating protein 23 -0.48
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.48
LAMA5 laminin, alpha 5 -0.47
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -0.47
MYO9A myosin IXA -0.47
PAM peptidylglycine alpha-amidating monooxygenase -0.47
TRMO tRNA methyltransferase O -0.47
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -0.46
UBQLN2 ubiquilin 2 -0.46
ZDHHC2 zinc finger, DHHC-type containing 2 -0.45
BHLHE40 basic helix-loop-helix family, member e40 -0.45
COL18A1 collagen, type XVIII, alpha 1 -0.45
ATF6B activating transcription factor 6 beta -0.45
RABL2A RAB, member of RAS oncogene family-like 2A -0.44
PRMT2IP PRMT2 interacting protein -0.44
ENTR1 endosome associated trafficking regulator 1 -0.44
PGLS 6-phosphogluconolactonase -0.44
ANGPTL4 angiopoietin-like 4 -0.44
CPA4 carboxypeptidase A4 -0.43
CTHRC1 collagen triple helix repeat containing 1 -0.43
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.43
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -0.43
CD109 CD109 molecule -0.43
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.42
H1-2 H1.2 linker histone, cluster member -0.42
MIB2 mindbomb E3 ubiquitin protein ligase 2 -0.42
BCAR3 breast cancer anti-estrogen resistance 3 -0.42
HYKK hydroxylysine kinase -0.42
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.42
LYPLAL1 lysophospholipase-like 1 -0.41
RNF149 ring finger protein 149 -0.41
NMRK1 nicotinamide riboside kinase 1 -0.41
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -0.41
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.41
PCSK9 proprotein convertase subtilisin/kexin type 9 -0.4
PLEKHN1 pleckstrin homology domain containing, family N member 1 -0.4
ANO8 anoctamin 8 -0.4
ASB1 ankyrin repeat and SOCS box containing 1 -0.4
CCND1 cyclin D1 -0.4
TOR1AIP2 torsin A interacting protein 2 -0.39
TICRR TOPBP1-interacting checkpoint and replication regulator -0.39
CALB2 calbindin 2 -0.39
ANTXR1 anthrax toxin receptor 1 -0.39
CD151 CD151 molecule (Raph blood group) -0.39
TGOLN2 trans-golgi network protein 2 -0.39
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.39
ERVMER34-1 endogenous retrovirus group MER34, member 1 -0.39
RSL24D1 ribosomal L24 domain containing 1 -0.38
GPC1 glypican 1 -0.38
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.38
CEP112 centrosomal protein 112kDa -0.38
TTN titin -0.38
FADS1 fatty acid desaturase 1 -0.38
CEP55 centrosomal protein 55kDa -0.38
RECQL4 RecQ protein-like 4 -0.38
AXL AXL receptor tyrosine kinase -0.38