S-Adenosyl-L-methionine (disulfate tosylate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.076619
PCBP2 poly(rC) binding protein 2 0.0400627
TENM3 teneurin transmembrane protein 3 0.0334971
TRIO trio Rho guanine nucleotide exchange factor 0.0310745
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0308652
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0265909
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0260905
WWOX WW domain containing oxidoreductase 0.0260235
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.024201
CCNL1 cyclin L1 0.0241452
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0237146
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0235252
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0224159
ZNF292 zinc finger protein 292 0.0203872
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0202161
FXR1 fragile X mental retardation, autosomal homolog 1 0.0201782
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0195575
SFPQ splicing factor proline/glutamine-rich 0.0193427
RBM25 RNA binding motif protein 25 0.0190968
EIF4A2 eukaryotic translation initiation factor 4A2 0.0190304
NEBL nebulette 0.0189923
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0187531
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0177857
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0176603
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0174066
YEATS2 YEATS domain containing 2 0.0171169
MTCL1 microtubule crosslinking factor 1 0.0170191
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0168264
EPHA6 EPH receptor A6 0.0166938
CELF2 CUGBP, Elav-like family member 2 0.0162358
RSF1 remodeling and spacing factor 1 0.0161188
ATP11A ATPase, class VI, type 11A 0.0158353
CCN2 cellular communication network factor 2 0.0157098
MYH9 myosin, heavy chain 9, non-muscle 0.0156949
BRD2 bromodomain containing 2 0.0156138
KDM4C lysine (K)-specific demethylase 4C 0.0153111
RNF213 ring finger protein 213 0.0151693
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0148951
TJP1 tight junction protein 1 0.0148684
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0148157
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0144786
ANKRD36 ankyrin repeat domain 36 0.0144142
SON SON DNA binding protein 0.0142721
FLNA filamin A, alpha 0.0140401
YAP1 Yes-associated protein 1 0.0136957
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0136715
SDK1 sidekick cell adhesion molecule 1 0.0136317
POTEF POTE ankyrin domain family, member F 0.013625
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0136008
WDR26 WD repeat domain 26 0.0134385
CCSER1 coiled-coil serine-rich protein 1 0.0134194
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0134119
AFF4 AF4/FMR2 family, member 4 0.0133439
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0131225
APLP2 amyloid beta (A4) precursor-like protein 2 0.0129737
HDAC4 histone deacetylase 4 0.0127252
HEXIM1 hexamethylene bis-acetamide inducible 1 0.0126987
ANKRD11 ankyrin repeat domain 11 0.0126797
HELZ helicase with zinc finger 0.0126577
FHIT fragile histidine triad 0.0126347
FUS FUS RNA binding protein 0.0126028
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0125478
RRM2 ribonucleotide reductase M2 0.0125408
PCM1 pericentriolar material 1 0.0125136
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0123856
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0122048
LRPPRC leucine-rich pentatricopeptide repeat containing 0.012141
GIGYF2 GRB10 interacting GYF protein 2 0.0120843
RUNX1 runt-related transcription factor 1 0.0119365
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.011923
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0118673
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0118591
TBC1D5 TBC1 domain family, member 5 0.0117891
ZNF638 zinc finger protein 638 0.0117383
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0116483
TRA2B transformer 2 beta homolog (Drosophila) 0.0115311
TRAPPC9 trafficking protein particle complex 9 0.0115174
TENT4A terminal nucleotidyltransferase 4A 0.0114383
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0113769
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.011331
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0113203
NCOR2 nuclear receptor corepressor 2 0.0112992
DIAPH1 diaphanous-related formin 1 0.0112849
RAD51B RAD51 paralog B 0.0112769
CABIN1 calcineurin binding protein 1 0.011239
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0111275
TPM3 tropomyosin 3 0.0111131
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0108526
BABAM2 BRISC and BRCA1 A complex member 2 0.010816
PRELID2 PRELI domain containing 2 0.0107587
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0107037
LRMDA leucine rich melanocyte differentiation associated 0.0106334
MYH10 myosin, heavy chain 10, non-muscle 0.0105588
XPO1 exportin 1 0.0105583
POU2F1 POU class 2 homeobox 1 0.0104178
UBA1 ubiquitin-like modifier activating enzyme 1 0.010368
EP400 E1A binding protein p400 0.0103415
TPR translocated promoter region, nuclear basket protein 0.0103216
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0102923
PTMS parathymosin 0.010289

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.251648
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.240206
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.169947
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0768673
MYL12B myosin, light chain 12B, regulatory -0.0752823
TMSB10 thymosin beta 10 -0.0716511
PTMA prothymosin, alpha -0.07093
TPT1 tumor protein, translationally-controlled 1 -0.0659909
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0641714
HMGA2 high mobility group AT-hook 2 -0.0616545
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0516991
IFIH1 interferon induced with helicase C domain 1 -0.0470771
RPS8 ribosomal protein S8 -0.0469617
ANXA1 annexin A1 -0.0447885
MMP12 matrix metallopeptidase 12 -0.0447438
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0430425
RPL26 ribosomal protein L26 -0.0413769
TMEM41B transmembrane protein 41B -0.0409081
RPLP0 ribosomal protein, large, P0 -0.0398379
EIF1 eukaryotic translation initiation factor 1 -0.039358
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0392416
KPNB1 karyopherin (importin) beta 1 -0.0391583
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0390732
CLDN1 claudin 1 -0.0376558
S100A6 S100 calcium binding protein A6 -0.0375135
RASAL2 RAS protein activator like 2 -0.0372842
RPS3 ribosomal protein S3 -0.0366205
ACTG1 actin gamma 1 -0.0362752
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0360649
JMJD1C jumonji domain containing 1C -0.0359771
PDE4D phosphodiesterase 4D, cAMP-specific -0.0358219
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0341871
RPS24 ribosomal protein S24 -0.0341395
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0334989
FTL ferritin, light polypeptide -0.0334407
SLC38A2 solute carrier family 38, member 2 -0.0332265
AREG amphiregulin -0.0328238
RPL35A ribosomal protein L35a -0.0319137
EHBP1 EH domain binding protein 1 -0.031443
LMO7 LIM domain 7 -0.0312195
RPL34 ribosomal protein L34 -0.0308803
GNAS GNAS complex locus -0.0307554
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0305
TMEM123 transmembrane protein 123 -0.0302762
RSL1D1 ribosomal L1 domain containing 1 -0.029655
TM4SF1 transmembrane 4 L six family member 1 -0.0296521
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0283809
S100A10 S100 calcium binding protein A10 -0.0282308
HSPB1 heat shock 27kDa protein 1 -0.0270444
RPLP1 ribosomal protein, large, P1 -0.0269529
KLF6 Kruppel-like factor 6 -0.0268048
RACK1 receptor for activated C kinase 1 -0.0265372
ZNF804A zinc finger protein 804A -0.0259145
TPI1 triosephosphate isomerase 1 -0.0258812
ANKRD12 ankyrin repeat domain 12 -0.0258087
CXADR coxsackie virus and adenovirus receptor -0.0256881
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0254028
RPL11 ribosomal protein L11 -0.0253456
GCG glucagon -0.0252049
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0251806
NAP1L1 nucleosome assembly protein 1-like 1 -0.0249162
PDGFC platelet derived growth factor C -0.0248984
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0246676
RPL12 ribosomal protein L12 -0.0246418
ENO1 enolase 1, (alpha) -0.0245364
RPL19 ribosomal protein L19 -0.0241525
ZBTB20 zinc finger and BTB domain containing 20 -0.0235512
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0234599
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0234429
RPS12 ribosomal protein S12 -0.0232891
RAB10 RAB10, member RAS oncogene family -0.0232445
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0232196
BIRC2 baculoviral IAP repeat containing 2 -0.0227001
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0226005
SLC38A1 solute carrier family 38, member 1 -0.0225719
RPS13 ribosomal protein S13 -0.0225335
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0225054
RPS16 ribosomal protein S16 -0.0223026
TUBA1B tubulin, alpha 1b -0.0219006
RPS27A ribosomal protein S27a -0.0218741
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0217942
RPL37 ribosomal protein L37 -0.0216584
ASPH aspartate beta-hydroxylase -0.0213862
BIRC3 baculoviral IAP repeat containing 3 -0.0209693
CCND1 cyclin D1 -0.0209491
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0206086
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0205832
RPS2 ribosomal protein S2 -0.0205175
CDK17 cyclin-dependent kinase 17 -0.020155
RPL38 ribosomal protein L38 -0.0200151
NACA nascent polypeptide-associated complex alpha subunit -0.0194153
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0191875
RPL23 ribosomal protein L23 -0.019043
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0190347
PDE4B phosphodiesterase 4B, cAMP-specific -0.0189766
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0188545
BCHE butyrylcholinesterase -0.0183683
NHSL1 NHS-like 1 -0.0183303
TPM4 tropomyosin 4 -0.0179835
IL6ST interleukin 6 signal transducer -0.0179365