S-Adenosyl-L-methionine (disulfate tosylate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.0770001
GPC6 glypican 6 0.0710415
EXT1 exostosin glycosyltransferase 1 0.0565841
SMAD3 SMAD family member 3 0.056049
GLIS3 GLIS family zinc finger 3 0.0490109
PDLIM5 PDZ and LIM domain 5 0.0462377
VCL vinculin 0.0427119
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0389099
TSHZ2 teashirt zinc finger homeobox 2 0.0375147
FNDC3B fibronectin type III domain containing 3B 0.0372822
TRIO trio Rho guanine nucleotide exchange factor 0.0368485
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0360554
PBX1 pre-B-cell leukemia homeobox 1 0.032693
RNF213 ring finger protein 213 0.0292064
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0255526
KYNU kynureninase 0.0254394
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0252533
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0241429
SHB Src homology 2 domain containing adaptor protein B 0.0237438
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0227195
SAMD4A sterile alpha motif domain containing 4A 0.0216166
EPAS1 endothelial PAS domain protein 1 0.0213046
FAT1 FAT atypical cadherin 1 0.0212908
SPIDR scaffolding protein involved in DNA repair 0.0204044
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0200404
EFNA5 ephrin-A5 0.0199633
NUP98 nucleoporin 98kDa 0.0192582
FLNA filamin A, alpha 0.0188446
RRM2 ribonucleotide reductase M2 0.0187114
TLE4 transducin-like enhancer of split 4 0.0186757
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0182088
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0178817
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.0176191
DOCK5 dedicator of cytokinesis 5 0.0168365
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0168207
PRKCA protein kinase C, alpha 0.0168119
ACTN4 actinin, alpha 4 0.016532
EHBP1 EH domain binding protein 1 0.0160893
ZSWIM6 zinc finger, SWIM-type containing 6 0.0157911
TENM3 teneurin transmembrane protein 3 0.0157662
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0157105
INTS6 integrator complex subunit 6 0.0152965
CORO1C coronin, actin binding protein, 1C 0.0148492
NRP1 neuropilin 1 0.0147804
RDH10 retinol dehydrogenase 10 (all-trans) 0.0147203
RUNX1 runt-related transcription factor 1 0.0146163
AFF1 AF4/FMR2 family, member 1 0.0145661
FAM20C family with sequence similarity 20, member C 0.0145085
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0144907
NFIB nuclear factor I/B 0.0143835
NF1 neurofibromin 1 0.0142236
ZNF644 zinc finger protein 644 0.014098
TUSC3 tumor suppressor candidate 3 0.0140896
PTH2R parathyroid hormone 2 receptor 0.0138957
DGKI diacylglycerol kinase, iota 0.0138433
ABTB3 ankyrin repeat and BTB domain containing 3 0.0138292
DOCK1 dedicator of cytokinesis 1 0.013828
FHL2 four and a half LIM domains 2 0.0136891
MRTFA myocardin related transcription factor A 0.0136511
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0136054
EXOC4 exocyst complex component 4 0.0135935
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0134589
NDEL1 nudE neurodevelopment protein 1-like 1 0.0133528
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0132383
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0131166
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0130609
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0129972
COL5A1 collagen, type V, alpha 1 0.0129956
NABP1 nucleic acid binding protein 1 0.0129059
PTPRG protein tyrosine phosphatase, receptor type, G 0.0128714
COL27A1 collagen, type XXVII, alpha 1 0.0128637
RABGAP1L RAB GTPase activating protein 1-like 0.0128388
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0126883
ECPAS Ecm29 proteasome adaptor and scaffold 0.0125445
RIGI RNA sensor RIG-I 0.0125398
DIAPH3 diaphanous-related formin 3 0.0124547
SEPTIN9 septin 9 0.0122324
MSR1 macrophage scavenger receptor 1 0.0122122
ATP13A3 ATPase type 13A3 0.0121857
CTBP2 C-terminal binding protein 2 0.0119319
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0119168
IFI44L interferon-induced protein 44-like 0.0118436
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0115443
PTK2 protein tyrosine kinase 2 0.0115036
PALLD palladin, cytoskeletal associated protein 0.0114968
UBASH3B ubiquitin associated and SH3 domain containing B 0.0114161
COL7A1 collagen, type VII, alpha 1 0.0114145
NCAPG2 non-SMC condensin II complex, subunit G2 0.0114138
BICD1 bicaudal D homolog 1 (Drosophila) 0.0113491
MB21D2 Mab-21 domain containing 2 0.0112691
MPRIP myosin phosphatase Rho interacting protein 0.0112672
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0112019
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0111662
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0111241
SH3RF1 SH3 domain containing ring finger 1 0.0111079
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0110023
BICC1 BicC family RNA binding protein 1 0.0109869
PDE4D phosphodiesterase 4D, cAMP-specific 0.010963
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0109237
PUM3 pumilio RNA binding family member 3 0.0109055

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.218902
FTL ferritin, light polypeptide -0.189405
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.155421
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146485
IGFBP3 insulin-like growth factor binding protein 3 -0.128705
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113109
B2M beta-2-microglobulin -0.0992772
RPS6 ribosomal protein S6 -0.0968076
TMSB10 thymosin beta 10 -0.0953637
EIF1 eukaryotic translation initiation factor 1 -0.0703074
FTH1 ferritin, heavy polypeptide 1 -0.0679446
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0637641
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0611945
HSPB1 heat shock 27kDa protein 1 -0.0611716
RPS8 ribosomal protein S8 -0.0607737
PTMA prothymosin, alpha -0.060176
CANX calnexin -0.0599456
CALR calreticulin -0.0587813
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0568995
DDIT4 DNA-damage-inducible transcript 4 -0.0559852
PDIA3 protein disulfide isomerase family A, member 3 -0.0506237
MT2A metallothionein 2A -0.0504516
RPL12 ribosomal protein L12 -0.0499704
CA12 carbonic anhydrase XII -0.0494872
PLIN2 perilipin 2 -0.0492703
HLA-B major histocompatibility complex, class I, B -0.0492676
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.049108
RPL23 ribosomal protein L23 -0.0488756
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.047327
PRRC2C proline-rich coiled-coil 2C -0.0472158
RPS19 ribosomal protein S19 -0.0449172
RPL19 ribosomal protein L19 -0.0447673
TKT transketolase -0.0446002
GOLGA4 golgin A4 -0.043619
RPLP1 ribosomal protein, large, P1 -0.0428377
UBC ubiquitin C -0.0418737
ANXA1 annexin A1 -0.0412554
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0409126
NAMPT nicotinamide phosphoribosyltransferase -0.0409084
TPT1 tumor protein, translationally-controlled 1 -0.0405978
TFPI2 tissue factor pathway inhibitor 2 -0.0401499
MTDH metadherin -0.0399699
NDRG1 N-myc downstream regulated 1 -0.0395462
LDHA lactate dehydrogenase A -0.0391862
ANXA2 annexin A2 -0.038667
RPL37A ribosomal protein L37a -0.0383729
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0378687
ACBD3 acyl-CoA binding domain containing 3 -0.0377349
TPM4 tropomyosin 4 -0.037279
RPL31 ribosomal protein L31 -0.0358789
RPL34 ribosomal protein L34 -0.035659
PDIA6 protein disulfide isomerase family A, member 6 -0.0352525
RPL7 ribosomal protein L7 -0.0350943
RND3 Rho family GTPase 3 -0.034413
RPL8 ribosomal protein L8 -0.0343717
PKM pyruvate kinase, muscle -0.0341443
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0339568
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0335889
RAB2A RAB2A, member RAS oncogene family -0.0335711
RACK1 receptor for activated C kinase 1 -0.0334497
CAVIN1 caveolae associated protein 1 -0.0324464
RPS5 ribosomal protein S5 -0.0323754
LOC112694756 uncharaterized LOC112694756 -0.0322574
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0317701
RPL35A ribosomal protein L35a -0.0317072
RPS27A ribosomal protein S27a -0.0315742
SDCBP syndecan binding protein (syntenin) -0.0314994
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0313958
RPLP2 ribosomal protein, large, P2 -0.0309787
DSTN destrin (actin depolymerizing factor) -0.0309254
HLA-A major histocompatibility complex, class I, A -0.0308823
RPL26 ribosomal protein L26 -0.0307095
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0305002
RPS13 ribosomal protein S13 -0.0304047
NAP1L1 nucleosome assembly protein 1-like 1 -0.0302248
TRAM1 translocation associated membrane protein 1 -0.029897
RPS27 ribosomal protein S27 -0.0298591
S100A6 S100 calcium binding protein A6 -0.029814
S100A11 S100 calcium binding protein A11 -0.0297616
RPL35 ribosomal protein L35 -0.0293099
RPS20 ribosomal protein S20 -0.0292031
RPS4X ribosomal protein S4, X-linked -0.0290999
GDF15 growth differentiation factor 15 -0.0289977
HLA-E major histocompatibility complex, class I, E -0.0287967
AKAP9 A kinase (PRKA) anchor protein 9 -0.0287227
SET SET nuclear proto-oncogene -0.0284923
SQSTM1 sequestosome 1 -0.0284821
LMAN1 lectin, mannose-binding, 1 -0.028343
TPM3 tropomyosin 3 -0.0273783
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0273548
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0272269
RPS14 ribosomal protein S14 -0.027039
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0269921
PLK2 polo-like kinase 2 -0.0269633
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0269041
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0267411
S100A10 S100 calcium binding protein A10 -0.0264432
CALU calumenin -0.0264105
OPTN optineurin -0.0263907
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0262987