S-Adenosyl-L-methionine (disulfate tosylate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0693911
THSD4 thrombospondin, type I, domain containing 4 0.0436848
ZMYND8 zinc finger, MYND-type containing 8 0.0378859
CEP250 centrosomal protein 250kDa 0.0282204
SMYD3 SET and MYND domain containing 3 0.0274324
ACACA acetyl-CoA carboxylase alpha 0.0267241
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0253326
PLEC plectin 0.0247542
TRPS1 trichorhinophalangeal syndrome I 0.0241129
NCOA3 nuclear receptor coactivator 3 0.0240944
AHNAK AHNAK nucleoprotein 0.0236102
CDK12 cyclin-dependent kinase 12 0.023589
HSPA8 heat shock 70kDa protein 8 0.0235674
MYH9 myosin, heavy chain 9, non-muscle 0.0232786
IGFBP5 insulin-like growth factor binding protein 5 0.0229064
ASPH aspartate beta-hydroxylase 0.0227724
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.022398
TRAPPC9 trafficking protein particle complex 9 0.0204572
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0202226
SRCIN1 SRC kinase signaling inhibitor 1 0.0195273
ANKRD36C ankyrin repeat domain 36C 0.019298
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0191982
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0188003
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0186163
PRRC2B proline-rich coiled-coil 2B 0.0184365
PTPRK protein tyrosine phosphatase, receptor type, K 0.0181685
APP amyloid beta (A4) precursor protein 0.0173273
LASP1 LIM and SH3 protein 1 0.0172312
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0166552
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0166302
ZC3H11A zinc finger CCCH-type containing 11A 0.0159803
TRIO trio Rho guanine nucleotide exchange factor 0.0157016
DSPP dentin sialophosphoprotein 0.0156179
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0153161
GSE1 Gse1 coiled-coil protein 0.0149487
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0148399
FBXL20 F-box and leucine-rich repeat protein 20 0.0142146
PBX1 pre-B-cell leukemia homeobox 1 0.0138417
SEPTIN9 septin 9 0.0136797
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0134213
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0133412
UNC13B unc-13 homolog B (C. elegans) 0.0132662
LIMCH1 LIM and calponin homology domains 1 0.0129745
ELOVL5 ELOVL fatty acid elongase 5 0.0128393
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0128259
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0124998
KAZN kazrin, periplakin interacting protein 0.0122315
ADARB1 adenosine deaminase, RNA-specific, B1 0.0121053
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0121047
MACF1 microtubule-actin crosslinking factor 1 0.0120202
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0119585
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0118918
CEMIP cell migration inducing protein, hyaluronan binding 0.0118305
PTK2 protein tyrosine kinase 2 0.0118277
ZNF217 zinc finger protein 217 0.0117925
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0115552
MSI2 musashi RNA-binding protein 2 0.0115354
LPP LIM domain containing preferred translocation partner in lipoma 0.0113332
TOM1L1 target of myb1 (chicken)-like 1 0.0112604
ALCAM activated leukocyte cell adhesion molecule 0.0111879
KIF1A kinesin family member 1A 0.0111231
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0109023
EGFR epidermal growth factor receptor 0.0107892
H1-0 H1.0 linker histone 0.0107162
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0106296
FNDC3B fibronectin type III domain containing 3B 0.0105732
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0104636
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0103008
FAM13A family with sequence similarity 13, member A 0.010214
TENM2 teneurin transmembrane protein 2 0.0101521
PRRC2A proline-rich coiled-coil 2A 0.0100108
CANX calnexin 0.00996859
CTNND1 catenin (cadherin-associated protein), delta 1 0.0099345
DUSP16 dual specificity phosphatase 16 0.00985243
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.00978656
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.00978606
LGALS12 lectin, galactoside-binding, soluble, 12 0.00969826
MYO5B myosin VB 0.00969167
SHROOM3 shroom family member 3 0.00968718
KRT8 keratin 8, type II 0.00964507
SYTL2 synaptotagmin-like 2 0.00961693
RTF2 replication termination factor 2 0.00960901
EZR ezrin 0.00948516
SCARB2 scavenger receptor class B, member 2 0.00942756
TNIK TRAF2 and NCK interacting kinase 0.00937999
RNF213 ring finger protein 213 0.00935121
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00935059
KDM3A lysine (K)-specific demethylase 3A 0.00924562
VCP valosin containing protein 0.0092398
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0092127
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00921266
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00920622
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.00910462
ACTN4 actinin, alpha 4 0.00908067
ZHX2 zinc fingers and homeoboxes 2 0.00902165
DENND1A DENN/MADD domain containing 1A 0.00899679
MED13L mediator complex subunit 13-like 0.00895962
VAV3 vav 3 guanine nucleotide exchange factor 0.00894704
STIP1 stress-induced phosphoprotein 1 0.00889403
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0087789

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.203478
RPL19 ribosomal protein L19 -0.155243
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0889595
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0523445
TMSB10 thymosin beta 10 -0.0430348
RPL35A ribosomal protein L35a -0.0418376
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.035927
MT2A metallothionein 2A -0.0359021
TPT1 tumor protein, translationally-controlled 1 -0.0339457
RPS3 ribosomal protein S3 -0.0337081
RPL12 ribosomal protein L12 -0.0323107
FTH1 ferritin, heavy polypeptide 1 -0.030813
ACTG1 actin gamma 1 -0.0306857
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0298111
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0291406
RPL9 ribosomal protein L9 -0.0277819
NDRG1 N-myc downstream regulated 1 -0.027439
PTMA prothymosin, alpha -0.026926
RPS19 ribosomal protein S19 -0.0266452
RPS8 ribosomal protein S8 -0.0255854
IFI6 interferon, alpha-inducible protein 6 -0.0250383
RPS12 ribosomal protein S12 -0.0236591
RPL37A ribosomal protein L37a -0.0229462
RPS6 ribosomal protein S6 -0.0218264
MYL12B myosin, light chain 12B, regulatory -0.0211296
RPS29 ribosomal protein S29 -0.0210549
B2M beta-2-microglobulin -0.0209667
FTL ferritin, light polypeptide -0.0209633
RPL11 ribosomal protein L11 -0.0207545
RPL37 ribosomal protein L37 -0.0206198
RPS17 ribosomal protein S17 -0.0205436
RPL34 ribosomal protein L34 -0.0201512
RAB7A RAB7A, member RAS oncogene family -0.0200987
RPL31 ribosomal protein L31 -0.0200106
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0197878
RPLP0 ribosomal protein, large, P0 -0.0193621
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.019114
PFDN4 prefoldin subunit 4 -0.0190813
RPLP1 ribosomal protein, large, P1 -0.0188347
S100A9 S100 calcium binding protein A9 -0.018648
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0186089
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0185576
RPL30 ribosomal protein L30 -0.0183695
RPL35 ribosomal protein L35 -0.0182804
PRR11 proline rich 11 -0.0178702
RPL32 ribosomal protein L32 -0.0173266
RPS13 ribosomal protein S13 -0.017299
RPL36 ribosomal protein L36 -0.0171889
TUBA1B tubulin, alpha 1b -0.0167826
RPS14 ribosomal protein S14 -0.0167583
POTEF POTE ankyrin domain family, member F -0.0164804
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0163959
RPLP2 ribosomal protein, large, P2 -0.0161188
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0160727
ANKRD12 ankyrin repeat domain 12 -0.0159791
RPS24 ribosomal protein S24 -0.0158459
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.015756
RPL8 ribosomal protein L8 -0.0156584
RPS16 ribosomal protein S16 -0.0153473
RPL7A ribosomal protein L7a -0.0150056
RPL26 ribosomal protein L26 -0.0149966
EGR1 early growth response 1 -0.0149082
EIF1 eukaryotic translation initiation factor 1 -0.0148861
RPS25 ribosomal protein S25 -0.0148215
NDUFA4 NDUFA4, mitochondrial complex associated -0.0145918
DSTN destrin (actin depolymerizing factor) -0.0143416
CCNI cyclin I -0.0143415
WSB1 WD repeat and SOCS box containing 1 -0.0143272
ENO1 enolase 1, (alpha) -0.0142099
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.013966
RPL28 ribosomal protein L28 -0.0139468
KTN1 kinectin 1 (kinesin receptor) -0.0136882
MCL1 myeloid cell leukemia 1 -0.0134714
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0134405
RPS27 ribosomal protein S27 -0.0132798
RPS27A ribosomal protein S27a -0.0132735
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0131867
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0131516
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.0131288
RBM25 RNA binding motif protein 25 -0.0130729
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.012952
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0127038
CBX3 chromobox homolog 3 -0.0124305
RPS5 ribosomal protein S5 -0.0123576
TPI1 triosephosphate isomerase 1 -0.0123412
RPS21 ribosomal protein S21 -0.0122271
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0122019
RPL36A ribosomal protein L36a -0.0120637
TMEM165 transmembrane protein 165 -0.0119029
PNN pinin, desmosome associated protein -0.011835
RPL5 ribosomal protein L5 -0.0118151
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0116705
GNAS GNAS complex locus -0.0116341
RACK1 receptor for activated C kinase 1 -0.0116222
PFN1 profilin 1 -0.0116158
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.01157
SMC4 structural maintenance of chromosomes 4 -0.0115154
MIEN1 migration and invasion enhancer 1 -0.0114726
S100A6 S100 calcium binding protein A6 -0.0114091
RPL27A ribosomal protein L27a -0.0113629