S-Adenosyl-L-methionine (disulfate tosylate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) 0.196773
ERBB4 erb-b2 receptor tyrosine kinase 4 0.1378
TENM3 teneurin transmembrane protein 3 0.0998144
RAD51B RAD51 paralog B 0.0760877
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0705694
ZNF608 zinc finger protein 608 0.0696718
VCL vinculin 0.0695983
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0682793
NPAS3 neuronal PAS domain protein 3 0.0502703
RCC1 regulator of chromosome condensation 1 0.0495522
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0488378
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0468472
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0446348
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0435206
SMYD3 SET and MYND domain containing 3 0.0427592
CADM2 cell adhesion molecule 2 0.0420275
PDE4D phosphodiesterase 4D, cAMP-specific 0.0409219
RPL37A ribosomal protein L37a 0.0402409
RPL31 ribosomal protein L31 0.039896
TPT1 tumor protein, translationally-controlled 1 0.0387347
MLIP muscular LMNA-interacting protein 0.0382682
MCTP1 multiple C2 domains, transmembrane 1 0.0375388
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0375251
RPS8 ribosomal protein S8 0.0367056
IFI6 interferon, alpha-inducible protein 6 0.0348673
TMSB10 thymosin beta 10 0.0345953
PTMA prothymosin, alpha 0.0345478
ATP9A ATPase, class II, type 9A 0.0344184
INTS6 integrator complex subunit 6 0.0343191
NEBL nebulette 0.0337805
RIGI RNA sensor RIG-I 0.0336965
ARHGAP32 Rho GTPase activating protein 32 0.032683
VMP1 vacuole membrane protein 1 0.0299341
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0296162
RPS3 ribosomal protein S3 0.0290644
ZBTB20 zinc finger and BTB domain containing 20 0.0287105
DENND1A DENN/MADD domain containing 1A 0.028709
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0279364
TAS2R14 taste receptor, type 2, member 14 0.027825
OSBPL10 oxysterol binding protein-like 10 0.0274223
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0271963
HDAC4 histone deacetylase 4 0.0270336
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0266224
TTC28 tetratricopeptide repeat domain 28 0.026541
MSH4 mutS homolog 4 0.0259997
ENO1 enolase 1, (alpha) 0.0258588
AEBP2 AE binding protein 2 0.0254582
ASPH aspartate beta-hydroxylase 0.0253949
USP9X ubiquitin specific peptidase 9, X-linked 0.0253297
RPL9 ribosomal protein L9 0.0252852
RPL26 ribosomal protein L26 0.0244801
RPL23 ribosomal protein L23 0.0243045
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0240239
PTPRG protein tyrosine phosphatase, receptor type, G 0.023845
BNC2 basonuclin 2 0.0236108
SCFD1 sec1 family domain containing 1 0.0232838
NALF1 NALCN channel auxiliary factor 1 0.0230264
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0229658
RPS17 ribosomal protein S17 0.0229441
B2M beta-2-microglobulin 0.0228727
ZFAND3 zinc finger, AN1-type domain 3 0.0227698
MAML3 mastermind-like 3 (Drosophila) 0.0226512
EXOC4 exocyst complex component 4 0.0225899
EXT1 exostosin glycosyltransferase 1 0.0225705
TOX thymocyte selection-associated high mobility group box 0.0223911
ZSWIM6 zinc finger, SWIM-type containing 6 0.0223857
CTNND1 catenin (cadherin-associated protein), delta 1 0.0222891
DST dystonin 0.0222069
CELF2 CUGBP, Elav-like family member 2 0.0220092
RPLP2 ribosomal protein, large, P2 0.0219908
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0218597
RPS21 ribosomal protein S21 0.0216832
ZC3H12B zinc finger CCCH-type containing 12B 0.0213653
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0212348
RPLP1 ribosomal protein, large, P1 0.020961
NRG1 neuregulin 1 0.0208943
MACF1 microtubule-actin crosslinking factor 1 0.0208172
FBXL7 F-box and leucine-rich repeat protein 7 0.0207989
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0206613
ARID1B AT rich interactive domain 1B (SWI1-like) 0.020569
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0203062
ADGRG6 adhesion G protein-coupled receptor G6 0.0201888
AUTS2 autism susceptibility candidate 2 0.0201683
TBC1D22A TBC1 domain family, member 22A 0.020025
TRIP12 thyroid hormone receptor interactor 12 0.0197572
HSPA8 heat shock 70kDa protein 8 0.0196831
SHROOM3 shroom family member 3 0.0196516
WLS wntless Wnt ligand secretion mediator 0.0195985
ZNF407 zinc finger protein 407 0.01958
WAC WW domain containing adaptor with coiled-coil 0.0195766
SFPQ splicing factor proline/glutamine-rich 0.0195421
IGF2 insulin-like growth factor 2 0.0195374
RPS19 ribosomal protein S19 0.019489
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0192014
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0190762
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.0190744
JMJD1C jumonji domain containing 1C 0.0189878
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0188995
LARP4B La ribonucleoprotein domain family, member 4B 0.0188915
RPS27A ribosomal protein S27a 0.0188669

decreased expression

Symbol Name Standardized Value
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.078256
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0623972
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0598232
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0516951
NGLY1 N-glycanase 1 -0.0461423
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0442021
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0410823
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0406101
NUP58 nucleoporin 58 -0.0374971
ATRN attractin -0.0373209
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0354367
ZNF292 zinc finger protein 292 -0.0350893
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0319855
MXI1 MAX interactor 1, dimerization protein -0.0314359
KDM3A lysine (K)-specific demethylase 3A -0.0310517
ZNF638 zinc finger protein 638 -0.0306488
MATR3 matrin 3 -0.0292229
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0286408
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0285996
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0277792
WDR45B WD repeat domain 45B -0.0274971
GYS1 glycogen synthase 1 (muscle) -0.0255372
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0254621
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0249678
TPD52 tumor protein D52 -0.0248637
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.024476
FOXO3 forkhead box O3 -0.0240826
RNMT RNA (guanine-7-) methyltransferase -0.0234085
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0230771
NOP58 NOP58 ribonucleoprotein -0.0228899
SERBP1 SERPINE1 mRNA binding protein 1 -0.0218663
HELZ helicase with zinc finger -0.0218053
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0214328
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0214034
FNBP1L formin binding protein 1-like -0.0212783
SREBF2 sterol regulatory element binding transcription factor 2 -0.0209346
RHOA ras homolog family member A -0.0207577
FAM162A family with sequence similarity 162, member A -0.0206562
TTC3 tetratricopeptide repeat domain 3 -0.0206121
NCOR1 nuclear receptor corepressor 1 -0.0203381
EEF2 eukaryotic translation elongation factor 2 -0.0201748
RLF rearranged L-myc fusion -0.0201743
RNF145 ring finger protein 145 -0.0201245
RAB6A RAB6A, member RAS oncogene family -0.0199531
KMT2C lysine (K)-specific methyltransferase 2C -0.0198129
OGA O-GlcNAcase -0.0197999
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0195844
RFX7 regulatory factor X, 7 -0.0194824
RSRC2 arginine/serine-rich coiled-coil 2 -0.019376
PGAP1 post-GPI attachment to proteins 1 -0.0193363
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0191891
KTN1 kinectin 1 (kinesin receptor) -0.0188651
VEZT vezatin, adherens junctions transmembrane protein -0.0186102
INSIG2 insulin induced gene 2 -0.018543
ARFGEF3 ARFGEF family member 3 -0.0178923
USP3 ubiquitin specific peptidase 3 -0.0178163
TBK1 TANK-binding kinase 1 -0.0177562
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0176636
KPNB1 karyopherin (importin) beta 1 -0.0173544
YEATS2 YEATS domain containing 2 -0.0172745
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0171146
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0169949
ZMYM2 zinc finger, MYM-type 2 -0.0169404
LMAN1 lectin, mannose-binding, 1 -0.016937
ESYT2 extended synaptotagmin-like protein 2 -0.0166171
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0166119
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0165893
PIAS2 protein inhibitor of activated STAT, 2 -0.0165227
RBM25 RNA binding motif protein 25 -0.0164823
SYAP1 synapse associated protein 1 -0.0164254
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0164152
BRWD1 bromodomain and WD repeat domain containing 1 -0.0163226
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0162541
VDAC1 voltage-dependent anion channel 1 -0.0162138
SETD5 SET domain containing 5 -0.0160301
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0159982
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0159447
PUS7 pseudouridylate synthase 7 (putative) -0.0158847
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0158032
USP28 ubiquitin specific peptidase 28 -0.0156898
KDM2A lysine (K)-specific demethylase 2A -0.0155213
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -0.01533
PTCH1 patched 1 -0.0152086
XPO1 exportin 1 -0.0151554
PUM2 pumilio RNA-binding family member 2 -0.0151498
KIF5B kinesin family member 5B -0.0151383
YBX1 Y box binding protein 1 -0.015059
HMGA1 high mobility group AT-hook 1 -0.0150443
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0149621
CHSY1 chondroitin sulfate synthase 1 -0.0149402
KCMF1 potassium channel modulatory factor 1 -0.0147656
UBE4B ubiquitination factor E4B -0.0145205
KDM1A lysine (K)-specific demethylase 1A -0.014437
RYBP RING1 and YY1 binding protein -0.0143422
POM121 POM121 transmembrane nucleoporin -0.0142579
NAMPT nicotinamide phosphoribosyltransferase -0.0141377
SLF1 SMC5-SMC6 complex localization factor 1 -0.0141112
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0140968
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0140336
TMEM41B transmembrane protein 41B -0.013853