S-Adenosyl-L-methionine (disulfate tosylate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.123347
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0908389
CALU calumenin 0.0808645
PDIA4 protein disulfide isomerase family A, member 4 0.0703451
IFRD1 interferon-related developmental regulator 1 0.0648306
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0605467
TBC1D22A TBC1 domain family, member 22A 0.0530977
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0516969
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0491426
BACE2 beta-site APP-cleaving enzyme 2 0.0462269
FMNL2 formin-like 2 0.0455174
NAV2 neuron navigator 2 0.0449575
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0442074
NAV1 neuron navigator 1 0.0434757
CUX1 cut-like homeobox 1 0.0430373
KDM3A lysine (K)-specific demethylase 3A 0.0420823
SEPTIN9 septin 9 0.0404269
ZSWIM6 zinc finger, SWIM-type containing 6 0.0403668
ACTN1 actinin, alpha 1 0.0381722
COPA coatomer protein complex, subunit alpha 0.0368513
CPED1 cadherin-like and PC-esterase domain containing 1 0.0361776
AHNAK AHNAK nucleoprotein 0.0360976
TLE4 transducin-like enhancer of split 4 0.0355897
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0352996
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0349148
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0344117
CABIN1 calcineurin binding protein 1 0.0338401
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0337376
FUS FUS RNA binding protein 0.0334032
PLEC plectin 0.0329978
SND1 staphylococcal nuclease and tudor domain containing 1 0.032931
CTBP2 C-terminal binding protein 2 0.032457
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0324263
LMNA lamin A/C 0.0321659
ZMIZ1 zinc finger, MIZ-type containing 1 0.0320276
NPAS2 neuronal PAS domain protein 2 0.0320127
RASA3 RAS p21 protein activator 3 0.0318573
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0315253
MYO1E myosin IE 0.0314466
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0312944
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0312166
ATXN1 ataxin 1 0.0311632
EGR1 early growth response 1 0.0307329
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0306094
FLNB filamin B, beta 0.0304628
TIMP3 TIMP metallopeptidase inhibitor 3 0.0301147
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0299385
IGF1R insulin-like growth factor 1 receptor 0.029885
PTK2 protein tyrosine kinase 2 0.0298557
SETBP1 SET binding protein 1 0.0298332
INTS6 integrator complex subunit 6 0.0298118
CALR calreticulin 0.0297516
SKI SKI proto-oncogene 0.0291911
TRIO trio Rho guanine nucleotide exchange factor 0.0291757
MACF1 microtubule-actin crosslinking factor 1 0.0290891
KDM4B lysine (K)-specific demethylase 4B 0.0286897
PARVB parvin, beta 0.0286117
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0285951
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0285465
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0285232
CEMIP2 cell migration inducing hyaluronidase 2 0.0280764
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0269669
ESYT2 extended synaptotagmin-like protein 2 0.0269043
LRRC23 leucine rich repeat containing 23 0.0264675
SAMD4A sterile alpha motif domain containing 4A 0.0259752
NCOR2 nuclear receptor corepressor 2 0.0253606
WDR1 WD repeat domain 1 0.0253558
MYH9 myosin, heavy chain 9, non-muscle 0.0251229
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0250897
HIP1 huntingtin interacting protein 1 0.0250565
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0249769
TPR translocated promoter region, nuclear basket protein 0.0248865
POM121C POM121 transmembrane nucleoporin C 0.0247031
AFDN afadin, adherens junction formation factor 0.0242449
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0240893
UBASH3B ubiquitin associated and SH3 domain containing B 0.0236531
SOX13 SRY (sex determining region Y)-box 13 0.0236014
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0234687
DOCK1 dedicator of cytokinesis 1 0.0226389
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0225638
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0223728
PAX3 paired box 3 0.0223446
FLNA filamin A, alpha 0.0222439
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0222192
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0221536
EXT1 exostosin glycosyltransferase 1 0.0219818
PTPRG protein tyrosine phosphatase, receptor type, G 0.0218827
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0216673
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0216071
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0214329
NIBAN2 niban apoptosis regulator 2 0.0212272
TFRC transferrin receptor 0.0211122
SEC31A SEC31 homolog A (S. cerevisiae) 0.0210153
CANX calnexin 0.0205829
COG5 component of oligomeric golgi complex 5 0.0204053
UBE3C ubiquitin protein ligase E3C 0.0203295
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0203229
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0202188
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0199819
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0199187

decreased expression

Symbol Name Standardized Value
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.137049
NLGN1 neuroligin 1 -0.10073
FN1 fibronectin 1 -0.0938951
NAMPT nicotinamide phosphoribosyltransferase -0.0813781
GPC6 glypican 6 -0.0688135
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0669491
VIM vimentin -0.0668731
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0591886
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0573214
KMT2E lysine (K)-specific methyltransferase 2E -0.0547351
AHR aryl hydrocarbon receptor -0.0526613
TNNC1 troponin C type 1 (slow) -0.0496299
MACROD2 MACRO domain containing 2 -0.0484988
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0472234
DCT dopachrome tautomerase -0.047035
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0448063
IGFBP3 insulin-like growth factor binding protein 3 -0.0428455
OXR1 oxidation resistance 1 -0.040944
IFI16 interferon, gamma-inducible protein 16 -0.0407689
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.039174
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.039074
RNF145 ring finger protein 145 -0.0368992
AKAP12 A kinase (PRKA) anchor protein 12 -0.0364182
POTEF POTE ankyrin domain family, member F -0.036017
ENO1 enolase 1, (alpha) -0.035821
PCDH7 protocadherin 7 -0.0353253
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0349738
ZNF292 zinc finger protein 292 -0.0344671
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0340375
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0331421
TMSB10 thymosin beta 10 -0.0329383
PGK1 phosphoglycerate kinase 1 -0.0329264
TAGLN2 transgelin 2 -0.0323641
PI15 peptidase inhibitor 15 -0.0314047
FRMD4A FERM domain containing 4A -0.0309612
S100A6 S100 calcium binding protein A6 -0.0305627
CALD1 caldesmon 1 -0.0298466
HILPDA hypoxia inducible lipid droplet-associated -0.0288481
LEF1 lymphoid enhancer-binding factor 1 -0.0286058
PHF21A PHD finger protein 21A -0.0282825
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0278205
RTN4 reticulon 4 -0.0276807
FNDC3B fibronectin type III domain containing 3B -0.0273366
CENPF centromere protein F, 350/400kDa -0.0269135
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.025873
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0255599
IFI6 interferon, alpha-inducible protein 6 -0.0248421
CD109 CD109 molecule -0.0242007
A2M alpha-2-macroglobulin -0.0232806
MT2A metallothionein 2A -0.0229844
FTH1 ferritin, heavy polypeptide 1 -0.0229671
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0227257
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0220205
PRKD1 protein kinase D1 -0.0217093
PTPRD protein tyrosine phosphatase, receptor type, D -0.0208655
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0208122
B2M beta-2-microglobulin -0.0207957
IGFBP5 insulin-like growth factor binding protein 5 -0.0204408
ANKRD28 ankyrin repeat domain 28 -0.0201268
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0199185
NPC1 Niemann-Pick disease, type C1 -0.019842
CD59 CD59 molecule, complement regulatory protein -0.0187839
RPS12 ribosomal protein S12 -0.0183702
RAD51B RAD51 paralog B -0.0181231
RNF24 ring finger protein 24 -0.0177185
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0174215
PDE10A phosphodiesterase 10A -0.0174009
RFX7 regulatory factor X, 7 -0.0170603
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0170357
CHSY1 chondroitin sulfate synthase 1 -0.0169724
FOSL1 FOS-like antigen 1 -0.0169701
BABAM2 BRISC and BRCA1 A complex member 2 -0.0167746
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0167693
ASPH aspartate beta-hydroxylase -0.0164232
MTPN myotrophin -0.0163467
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0162343
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0159745
TBK1 TANK-binding kinase 1 -0.0157702
FBXO7 F-box protein 7 -0.0156046
HLA-A major histocompatibility complex, class I, A -0.0154367
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0153984
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0153673
IFITM1 interferon induced transmembrane protein 1 -0.01514
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0151072
PLIN2 perilipin 2 -0.0150862
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0150599
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.015051
FTL ferritin, light polypeptide -0.0149439
FOXJ3 forkhead box J3 -0.0147923
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0146515
UBXN4 UBX domain protein 4 -0.0145164
PNISR PNN-interacting serine/arginine-rich protein -0.0144098
SOX6 SRY (sex determining region Y)-box 6 -0.014322
CAPRIN1 cell cycle associated protein 1 -0.0143015
DPYD dihydropyrimidine dehydrogenase -0.0142814
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0140475
HLA-B major histocompatibility complex, class I, B -0.0138352
RPS2 ribosomal protein S2 -0.013788
TSPAN3 tetraspanin 3 -0.0137126
CDH19 cadherin 19, type 2 -0.0136618