S-Adenosyl-L-methionine (disulfate tosylate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0829846
MYH9 myosin, heavy chain 9, non-muscle 0.0801808
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0775585
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0773392
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.057482
ASPH aspartate beta-hydroxylase 0.0526427
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.044143
ANLN anillin, actin binding protein 0.0439105
PRELID2 PRELI domain containing 2 0.0422582
OGA O-GlcNAcase 0.0337712
MKI67 marker of proliferation Ki-67 0.0332441
PLEC plectin 0.0329587
APP amyloid beta (A4) precursor protein 0.0328315
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0327234
ANKRD36 ankyrin repeat domain 36 0.0320703
SMAD3 SMAD family member 3 0.0314903
WWOX WW domain containing oxidoreductase 0.0310077
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0293398
H1-0 H1.0 linker histone 0.0280203
KDM3A lysine (K)-specific demethylase 3A 0.0278129
CANX calnexin 0.0274706
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264631
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.025092
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0250258
LAMB3 laminin, beta 3 0.0250092
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0243122
SMYD3 SET and MYND domain containing 3 0.0231989
USP9X ubiquitin specific peptidase 9, X-linked 0.0229603
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0221259
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0220959
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0219774
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0217136
ZC3H11A zinc finger CCCH-type containing 11A 0.0215611
PTK2 protein tyrosine kinase 2 0.0206066
HMGB2 high mobility group box 2 0.0204324
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0204013
HMGA2 high mobility group AT-hook 2 0.0202423
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0199893
DOCK1 dedicator of cytokinesis 1 0.0186537
AFDN afadin, adherens junction formation factor 0.0186258
SRSF1 serine/arginine-rich splicing factor 1 0.0181329
H1-4 H1.4 linker histone, cluster member 0.0177145
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0176845
SERINC1 serine incorporator 1 0.0175765
HSPA8 heat shock 70kDa protein 8 0.0173686
ALCAM activated leukocyte cell adhesion molecule 0.0171413
KLF6 Kruppel-like factor 6 0.0169947
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0169001
SOD2 superoxide dismutase 2, mitochondrial 0.0168059
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0164544
DSPP dentin sialophosphoprotein 0.0163875
TM9SF3 transmembrane 9 superfamily member 3 0.0163407
DLG1 discs, large homolog 1 (Drosophila) 0.0158706
TJP1 tight junction protein 1 0.0158689
NRIP1 nuclear receptor interacting protein 1 0.0158186
TRIO trio Rho guanine nucleotide exchange factor 0.0157736
TXNRD1 thioredoxin reductase 1 0.0156474
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0155374
H1-2 H1.2 linker histone, cluster member 0.0154867
CKAP5 cytoskeleton associated protein 5 0.0154528
PDIA4 protein disulfide isomerase family A, member 4 0.0154512
FHIT fragile histidine triad 0.0154364
MACF1 microtubule-actin crosslinking factor 1 0.0152375
TPST1 tyrosylprotein sulfotransferase 1 0.0149874
RASA3 RAS p21 protein activator 3 0.0149739
EIF4H eukaryotic translation initiation factor 4H 0.0148368
LARS1 leucyl-tRNA synthetase 1 0.0148035
EXOC4 exocyst complex component 4 0.0148014
TBCD tubulin folding cofactor D 0.0145989
RAD21 RAD21 homolog (S. pombe) 0.0144047
LMO7 LIM domain 7 0.0141219
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0140833
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0140057
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0140017
FBXL17 F-box and leucine-rich repeat protein 17 0.0137588
TNPO1 transportin 1 0.0137385
MYH10 myosin, heavy chain 10, non-muscle 0.0135913
INVS inversin 0.013575
CALU calumenin 0.013543
BIRC2 baculoviral IAP repeat containing 2 0.0133539
BBX bobby sox homolog (Drosophila) 0.0133275
TRIP12 thyroid hormone receptor interactor 12 0.0133153
CAMTA1 calmodulin binding transcription activator 1 0.013234
ZNF217 zinc finger protein 217 0.0132042
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0131409
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0130253
CTBP2 C-terminal binding protein 2 0.012986
ZFAND3 zinc finger, AN1-type domain 3 0.0129685
MACROD2 MACRO domain containing 2 0.0129672
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0129503
MAP4 microtubule-associated protein 4 0.0127679
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0127447
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0127117
RPL14 ribosomal protein L14 0.0126683
CLTC clathrin, heavy chain (Hc) 0.0125127
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0124594
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0124183
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0122698
ANKRD28 ankyrin repeat domain 28 0.0122646
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0122528

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.325887
FTL ferritin, light polypeptide -0.152712
MT2A metallothionein 2A -0.148919
TMSB10 thymosin beta 10 -0.122485
ACTG1 actin gamma 1 -0.116947
IGFBP3 insulin-like growth factor binding protein 3 -0.107921
POTEF POTE ankyrin domain family, member F -0.103648
NDRG1 N-myc downstream regulated 1 -0.0989083
B2M beta-2-microglobulin -0.0897949
RPS6 ribosomal protein S6 -0.087437
PKM pyruvate kinase, muscle -0.0848471
HMGA1 high mobility group AT-hook 1 -0.0827153
ENO1 enolase 1, (alpha) -0.0815377
LDHA lactate dehydrogenase A -0.07289
RPL35A ribosomal protein L35a -0.0712371
RPS8 ribosomal protein S8 -0.0687468
KRT7 keratin 7, type II -0.0656007
CCND1 cyclin D1 -0.063779
RPS12 ribosomal protein S12 -0.0615929
S100A10 S100 calcium binding protein A10 -0.0565651
RPLP0 ribosomal protein, large, P0 -0.0556538
RPL31 ribosomal protein L31 -0.0543543
RACK1 receptor for activated C kinase 1 -0.0538541
RPL23 ribosomal protein L23 -0.0516237
RPS19 ribosomal protein S19 -0.0512856
RPLP1 ribosomal protein, large, P1 -0.0508092
RPL12 ribosomal protein L12 -0.0506695
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0496268
RPL28 ribosomal protein L28 -0.049576
EGR1 early growth response 1 -0.0495224
TPM4 tropomyosin 4 -0.0494561
FTH1 ferritin, heavy polypeptide 1 -0.0493985
EEF2 eukaryotic translation elongation factor 2 -0.0488638
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0462707
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0462476
PFN1 profilin 1 -0.0455355
LOC112694756 uncharaterized LOC112694756 -0.0438113
RPL35 ribosomal protein L35 -0.0426242
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0425881
RPS14 ribosomal protein S14 -0.0421467
S100A6 S100 calcium binding protein A6 -0.04201
RPL11 ribosomal protein L11 -0.0419996
RPS2 ribosomal protein S2 -0.0411203
RPL8 ribosomal protein L8 -0.0405992
RPS5 ribosomal protein S5 -0.0402335
PCBP2 poly(rC) binding protein 2 -0.0391272
RPL32 ribosomal protein L32 -0.0387608
SEPTIN7 septin 7 -0.0373979
RPL34 ribosomal protein L34 -0.0371678
RPL19 ribosomal protein L19 -0.0369548
TPI1 triosephosphate isomerase 1 -0.0368127
RPS4X ribosomal protein S4, X-linked -0.0365844
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0365005
CLDN4 claudin 4 -0.0354611
BPTF bromodomain PHD finger transcription factor -0.0350028
MYADM myeloid-associated differentiation marker -0.033436
S100A9 S100 calcium binding protein A9 -0.0333365
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0327803
YBX1 Y box binding protein 1 -0.0327045
RPL9 ribosomal protein L9 -0.0321975
TSC22D2 TSC22 domain family, member 2 -0.0319984
RPS16 ribosomal protein S16 -0.031618
RPS17 ribosomal protein S17 -0.0315066
RPS3 ribosomal protein S3 -0.0303239
GNAS GNAS complex locus -0.0297959
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0296235
EIF1 eukaryotic translation initiation factor 1 -0.0296083
EEF1G eukaryotic translation elongation factor 1 gamma -0.0292418
HELZ helicase with zinc finger -0.0289461
KRT19 keratin 19, type I -0.0280032
ANXA2 annexin A2 -0.0279383
HILPDA hypoxia inducible lipid droplet-associated -0.0276831
RPL15 ribosomal protein L15 -0.0273032
LMAN1 lectin, mannose-binding, 1 -0.0272219
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0270398
CDCP1 CUB domain containing protein 1 -0.0267768
RPL37 ribosomal protein L37 -0.0267499
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0264615
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0260285
DSTN destrin (actin depolymerizing factor) -0.025829
RPS11 ribosomal protein S11 -0.0258098
RPL26 ribosomal protein L26 -0.0257435
RPS15 ribosomal protein S15 -0.0257424
RPL5 ribosomal protein L5 -0.0256729
RPLP2 ribosomal protein, large, P2 -0.0256238
SETD5 SET domain containing 5 -0.02554
RPL27 ribosomal protein L27 -0.0254518
FAM162A family with sequence similarity 162, member A -0.0252479
RPS27 ribosomal protein S27 -0.0250676
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0244842
WWC1 WW and C2 domain containing 1 -0.0244042
GOLGA4 golgin A4 -0.0243204
FOSL1 FOS-like antigen 1 -0.0240242
RPS13 ribosomal protein S13 -0.0234884
PDIA3 protein disulfide isomerase family A, member 3 -0.0234435
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0233225
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.023318
RPS23 ribosomal protein S23 -0.023162
RPS29 ribosomal protein S29 -0.0230755
ADAM9 ADAM metallopeptidase domain 9 -0.0230156