S-Adenosyl-L-methionine (disulfate tosylate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.154017
EXT1 exostosin glycosyltransferase 1 0.133591
UBC ubiquitin C 0.0978591
PDIA4 protein disulfide isomerase family A, member 4 0.0905011
SMAD3 SMAD family member 3 0.0903503
ADARB1 adenosine deaminase, RNA-specific, B1 0.0840128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0815591
HYOU1 hypoxia up-regulated 1 0.0672445
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0601189
INTS6 integrator complex subunit 6 0.0600468
PDIA3 protein disulfide isomerase family A, member 3 0.0569841
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0564914
LMO7 LIM domain 7 0.0555627
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0542374
ATXN1 ataxin 1 0.0528783
CTBP2 C-terminal binding protein 2 0.0493914
PCBP2 poly(rC) binding protein 2 0.0484238
ZSWIM6 zinc finger, SWIM-type containing 6 0.0476999
TRAPPC9 trafficking protein particle complex 9 0.0476767
TJP1 tight junction protein 1 0.0468521
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0466686
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0464698
AHNAK AHNAK nucleoprotein 0.0463323
CTNND1 catenin (cadherin-associated protein), delta 1 0.0453672
VMP1 vacuole membrane protein 1 0.0451279
EEF2 eukaryotic translation elongation factor 2 0.0433174
ACTN4 actinin, alpha 4 0.0429864
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0428859
RPS27A ribosomal protein S27a 0.0409606
FNDC3B fibronectin type III domain containing 3B 0.0400638
DSCAM Down syndrome cell adhesion molecule 0.0396357
PDLIM5 PDZ and LIM domain 5 0.0383045
OGA O-GlcNAcase 0.0372196
MBNL2 muscleblind-like splicing regulator 2 0.0371244
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0360921
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0355061
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0353278
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0353101
APLP2 amyloid beta (A4) precursor-like protein 2 0.0339329
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0323161
VCL vinculin 0.0321765
PDIA6 protein disulfide isomerase family A, member 6 0.0320616
CANX calnexin 0.0320196
PLEC plectin 0.0319643
SAMD4A sterile alpha motif domain containing 4A 0.0318487
TUFT1 tuftelin 1 0.0313881
KDM6A lysine (K)-specific demethylase 6A 0.0313534
FAT1 FAT atypical cadherin 1 0.0309743
MYH9 myosin, heavy chain 9, non-muscle 0.0306362
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.030348
CEMIP2 cell migration inducing hyaluronidase 2 0.0302928
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0302856
MCL1 myeloid cell leukemia 1 0.0302185
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0292969
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0291283
SFPQ splicing factor proline/glutamine-rich 0.0289367
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0286994
ANKRD11 ankyrin repeat domain 11 0.0286175
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0285752
PTK2 protein tyrosine kinase 2 0.0282888
CALR calreticulin 0.0282143
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0279256
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0275202
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0272692
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0268485
TOP1 topoisomerase (DNA) I 0.02676
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0266185
RBM39 RNA binding motif protein 39 0.0263923
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0263156
PDZD8 PDZ domain containing 8 0.0262283
SEC31A SEC31 homolog A (S. cerevisiae) 0.0261304
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0255763
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0251366
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0250653
HDLBP high density lipoprotein binding protein 0.0250054
SND1 staphylococcal nuclease and tudor domain containing 1 0.0244337
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.024415
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0242488
CALU calumenin 0.0242108
JUN jun proto-oncogene 0.0240015
PRR5L proline rich 5 like 0.0239262
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0237998
ERRFI1 ERBB receptor feedback inhibitor 1 0.0237482
ARHGAP29 Rho GTPase activating protein 29 0.0236648
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0234856
EIF4B eukaryotic translation initiation factor 4B 0.0234703
SIK3 SIK family kinase 3 0.0232782
PLK2 polo-like kinase 2 0.0231765
IFRD1 interferon-related developmental regulator 1 0.0228667
RBM33 RNA binding motif protein 33 0.0226626
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0224501
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0224289
LCOR ligand dependent nuclear receptor corepressor 0.022326
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0222579
FLNA filamin A, alpha 0.0221934
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0221599
PRKN parkin RBR E3 ubiquitin protein ligase 0.0218144
AKAP13 A kinase (PRKA) anchor protein 13 0.0217288
ZFAND3 zinc finger, AN1-type domain 3 0.0216906
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0214529

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.156377
TPT1 tumor protein, translationally-controlled 1 -0.123576
NDRG1 N-myc downstream regulated 1 -0.118381
FTH1 ferritin, heavy polypeptide 1 -0.11677
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0953209
LOC102724023 ES1 protein homolog, mitochondrial -0.0787593
RPS6 ribosomal protein S6 -0.0744613
RPL35A ribosomal protein L35a -0.0617935
RPLP1 ribosomal protein, large, P1 -0.0615482
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0599609
TMSB10 thymosin beta 10 -0.0570514
RPS19 ribosomal protein S19 -0.0533065
PTMA prothymosin, alpha -0.0531923
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0480941
B2M beta-2-microglobulin -0.0451173
PLAUR plasminogen activator, urokinase receptor -0.0430754
RPLP0 ribosomal protein, large, P0 -0.0410492
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0399353
RPL34 ribosomal protein L34 -0.0399249
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0377146
KRT19 keratin 19, type I -0.0374127
RPL11 ribosomal protein L11 -0.0372157
KRT18 keratin 18, type I -0.0357122
LDHA lactate dehydrogenase A -0.0354371
RPS8 ribosomal protein S8 -0.0336239
LYZ lysozyme -0.0333
EGR1 early growth response 1 -0.0313186
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0308729
RPL12 ribosomal protein L12 -0.0300726
RPS24 ribosomal protein S24 -0.0294318
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0293653
RPL31 ribosomal protein L31 -0.0287572
S100A10 S100 calcium binding protein A10 -0.028219
KLF10 Kruppel-like factor 10 -0.0280978
HMGA1 high mobility group AT-hook 1 -0.0280739
S100A6 S100 calcium binding protein A6 -0.027757
PGK1 phosphoglycerate kinase 1 -0.0276258
RPS3 ribosomal protein S3 -0.0274204
LOC112694756 uncharaterized LOC112694756 -0.0268006
RPS14 ribosomal protein S14 -0.0266127
ACTG1 actin gamma 1 -0.0263807
ITPKC inositol-trisphosphate 3-kinase C -0.0263182
S100P S100 calcium binding protein P -0.0262852
RPS21 ribosomal protein S21 -0.0258874
RPL23 ribosomal protein L23 -0.0244454
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0243967
RPL26 ribosomal protein L26 -0.0241253
NECTIN2 nectin cell adhesion molecule 2 -0.0239591
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0239152
ANXA2 annexin A2 -0.0238759
RPL27A ribosomal protein L27a -0.0238385
RPL9 ribosomal protein L9 -0.0238272
WASF2 WAS protein family, member 2 -0.0232696
RPS12 ribosomal protein S12 -0.0230413
RPS13 ribosomal protein S13 -0.0229495
RPL37 ribosomal protein L37 -0.0224091
TPI1 triosephosphate isomerase 1 -0.0222163
RPL19 ribosomal protein L19 -0.0219064
KPNB1 karyopherin (importin) beta 1 -0.0217621
EIF1 eukaryotic translation initiation factor 1 -0.0216462
RPL13A ribosomal protein L13a -0.0215378
RPL30 ribosomal protein L30 -0.0209652
MYL12B myosin, light chain 12B, regulatory -0.0203256
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0199956
CNRIP1 cannabinoid receptor interacting protein 1 -0.0199259
SERF2 small EDRK-rich factor 2 -0.0198307
CRABP2 cellular retinoic acid binding protein 2 -0.0196667
TM4SF4 transmembrane 4 L six family member 4 -0.0195205
GPX2 glutathione peroxidase 2 -0.0194385
DIAPH2 diaphanous-related formin 2 -0.0191539
ASTN2 astrotactin 2 -0.0190948
RPS23 ribosomal protein S23 -0.0189883
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0186165
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.018451
RPS27 ribosomal protein S27 -0.0183638
KLF3 Kruppel-like factor 3 (basic) -0.0182516
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0177658
FRY furry homolog (Drosophila) -0.0174972
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0173487
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.017348
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0172788
RPL7 ribosomal protein L7 -0.0171702
RACK1 receptor for activated C kinase 1 -0.0171092
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0170607
TMC5 transmembrane channel-like 5 -0.0170457
RPL18 ribosomal protein L18 -0.0170167
TUBB4B tubulin, beta 4B class IVb -0.0168714
ARF1 ADP-ribosylation factor 1 -0.0168294
FOSL1 FOS-like antigen 1 -0.0167516
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.016731
TMEM45B transmembrane protein 45B -0.0167232
KLF6 Kruppel-like factor 6 -0.016649
WDR45B WD repeat domain 45B -0.0165385
MKI67 marker of proliferation Ki-67 -0.0164295
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0163571
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0163419
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0163378
KLK10 kallikrein-related peptidase 10 -0.0162795
RPL36A ribosomal protein L36a -0.0162484
S100A9 S100 calcium binding protein A9 -0.01609