S-Adenosyl-L-methionine (disulfate tosylate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.117679
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0969976
HLA-B major histocompatibility complex, class I, B 0.0760381
TPT1 tumor protein, translationally-controlled 1 0.0756515
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0742348
RPS25 ribosomal protein S25 0.0601237
RPS8 ribosomal protein S8 0.0546573
CLU clusterin 0.0515531
RPS21 ribosomal protein S21 0.0494343
S100A10 S100 calcium binding protein A10 0.0493733
STC1 stanniocalcin 1 0.0463944
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0446627
RPL35A ribosomal protein L35a 0.0440337
NAMPT nicotinamide phosphoribosyltransferase 0.0421293
RPL34 ribosomal protein L34 0.0404772
RPS24 ribosomal protein S24 0.0401226
OGA O-GlcNAcase 0.0391076
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0388129
RPLP1 ribosomal protein, large, P1 0.0387527
GNAS GNAS complex locus 0.0379406
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0369388
B2M beta-2-microglobulin 0.0368998
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0330201
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0329399
RPLP2 ribosomal protein, large, P2 0.0328386
KDM3A lysine (K)-specific demethylase 3A 0.0327382
RPS29 ribosomal protein S29 0.0322268
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0320881
CAVIN1 caveolae associated protein 1 0.0319416
MT2A metallothionein 2A 0.0315887
EMP1 epithelial membrane protein 1 0.0313898
HM13 histocompatibility (minor) 13 0.0303883
RPS6 ribosomal protein S6 0.0297148
BLCAP bladder cancer associated protein 0.0296741
RPL7A ribosomal protein L7a 0.0296166
RPS23 ribosomal protein S23 0.0294901
GOLGA4 golgin A4 0.0294395
RPL36A ribosomal protein L36a 0.0287244
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0285013
RPS27A ribosomal protein S27a 0.0277173
CANX calnexin 0.0277165
VDAC1 voltage-dependent anion channel 1 0.0274856
DSTN destrin (actin depolymerizing factor) 0.0271177
ARRDC3 arrestin domain containing 3 0.0270932
RPS11 ribosomal protein S11 0.02705
RPL8 ribosomal protein L8 0.0262283
NPEPPS aminopeptidase puromycin sensitive 0.0259596
UBC ubiquitin C 0.0259269
KIAA1217 KIAA1217 0.0249303
CEMIP cell migration inducing protein, hyaluronan binding 0.024811
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0245233
RPL12 ribosomal protein L12 0.024385
WSB1 WD repeat and SOCS box containing 1 0.0242997
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0240062
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0239301
EIF1 eukaryotic translation initiation factor 1 0.0238617
LOXL2 lysyl oxidase-like 2 0.0237404
ZNFX1 zinc finger, NFX1-type containing 1 0.0235254
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0234776
MARCHF6 membrane associated ring-CH-type finger 6 0.02328
S100A6 S100 calcium binding protein A6 0.0232551
RPS13 ribosomal protein S13 0.023231
SEC31A SEC31 homolog A (S. cerevisiae) 0.0230504
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0230225
CUL4B cullin 4B 0.0229083
SFTPA2 surfactant protein A2 0.02274
EEF2 eukaryotic translation elongation factor 2 0.0226575
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0225011
TMSB4X thymosin beta 4, X-linked 0.022008
ARF1 ADP-ribosylation factor 1 0.0219035
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0217757
RPL37A ribosomal protein L37a 0.0215554
CALR calreticulin 0.0214577
PLEC plectin 0.0213422
RPL19 ribosomal protein L19 0.021227
STAU1 staufen double-stranded RNA binding protein 1 0.0210574
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0209978
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0208008
MGP matrix Gla protein 0.0206355
IER3 immediate early response 3 0.0204863
RPL27A ribosomal protein L27a 0.0203809
LMNA lamin A/C 0.0202503
RPL26 ribosomal protein L26 0.0202322
SRP72 signal recognition particle 72kDa 0.0200699
ZFR zinc finger RNA binding protein 0.0200496
RPS10 ribosomal protein S10 0.0200132
ADIRF adipogenesis regulatory factor 0.0199005
SP100 SP100 nuclear antigen 0.0198483
IGF2 insulin-like growth factor 2 0.0197869
ACBD3 acyl-CoA binding domain containing 3 0.0196609
CD99 CD99 molecule 0.0193317
RPL38 ribosomal protein L38 0.0193096
HLA-E major histocompatibility complex, class I, E 0.0191468
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0190735
FAM107B family with sequence similarity 107, member B 0.0187896
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0187262
MORF4L2 mortality factor 4 like 2 0.018532
CTNND1 catenin (cadherin-associated protein), delta 1 0.0184657
PLAT plasminogen activator, tissue 0.0184454
IFI6 interferon, alpha-inducible protein 6 0.0184029

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.121518
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.110555
PALM2AKAP2 PALM2 and AKAP2 fusion -0.109078
FLNB filamin B, beta -0.10764
DPYD dihydropyrimidine dehydrogenase -0.097966
MTSS1 metastasis suppressor 1 -0.0908924
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0898513
PDLIM5 PDZ and LIM domain 5 -0.0811145
SLC35F3 solute carrier family 35, member F3 -0.0713463
LMO7 LIM domain 7 -0.0673332
PSD3 pleckstrin and Sec7 domain containing 3 -0.0651074
PDE4D phosphodiesterase 4D, cAMP-specific -0.0641371
LAMC2 laminin, gamma 2 -0.0632993
ANO1 anoctamin 1, calcium activated chloride channel -0.0629618
PLS3 plastin 3 -0.0616774
HMGA2 high mobility group AT-hook 2 -0.0584027
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0580809
PRSS23 protease, serine, 23 -0.0578364
ALCAM activated leukocyte cell adhesion molecule -0.0572798
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0532037
AMOTL1 angiomotin like 1 -0.0521825
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.052135
BCAR3 breast cancer anti-estrogen resistance 3 -0.051759
INTS6 integrator complex subunit 6 -0.0505612
RAI14 retinoic acid induced 14 -0.0501654
POTEF POTE ankyrin domain family, member F -0.0500848
MECOM MDS1 and EVI1 complex locus -0.0499331
MSN moesin -0.0473028
RASAL2 RAS protein activator like 2 -0.0472178
EXT1 exostosin glycosyltransferase 1 -0.0465027
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0458908
THSD4 thrombospondin, type I, domain containing 4 -0.0456986
CDK6 cyclin-dependent kinase 6 -0.0455603
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0453218
MYH9 myosin, heavy chain 9, non-muscle -0.045314
GRB10 growth factor receptor-bound protein 10 -0.0451795
SULF2 sulfatase 2 -0.0451044
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0450709
PICALM phosphatidylinositol binding clathrin assembly protein -0.045052
LAMA5 laminin, alpha 5 -0.0439001
TIMP3 TIMP metallopeptidase inhibitor 3 -0.043167
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0429515
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0423659
FTH1 ferritin, heavy polypeptide 1 -0.0391073
RCOR1 REST corepressor 1 -0.038253
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0371506
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0368048
TRIO trio Rho guanine nucleotide exchange factor -0.0361663
TJP1 tight junction protein 1 -0.035265
MPRIP myosin phosphatase Rho interacting protein -0.0347319
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0340641
LUZP1 leucine zipper protein 1 -0.0338992
RNF217 ring finger protein 217 -0.033378
HSPG2 heparan sulfate proteoglycan 2 -0.0333359
KLF12 Kruppel-like factor 12 -0.0332642
ACTN4 actinin, alpha 4 -0.032978
SULF1 sulfatase 1 -0.0328598
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0327801
PALLD palladin, cytoskeletal associated protein -0.0326678
HMGA1 high mobility group AT-hook 1 -0.0310898
EGFR epidermal growth factor receptor -0.0310878
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0307055
NRIP1 nuclear receptor interacting protein 1 -0.030233
RABGAP1L RAB GTPase activating protein 1-like -0.0301145
PLCE1 phospholipase C, epsilon 1 -0.0300873
PTK2 protein tyrosine kinase 2 -0.029037
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0288821
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0288136
DGKH diacylglycerol kinase, eta -0.0285424
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0284567
CAPRIN2 caprin family member 2 -0.0281809
NAV2 neuron navigator 2 -0.0281508
DENND1A DENN/MADD domain containing 1A -0.0281113
ZEB1 zinc finger E-box binding homeobox 1 -0.0279962
AKAP13 A kinase (PRKA) anchor protein 13 -0.0278275
FOXO1 forkhead box O1 -0.0277632
SETX senataxin -0.0277491
NEK7 NIMA-related kinase 7 -0.0276237
CDK17 cyclin-dependent kinase 17 -0.0274828
RAP1B RAP1B, member of RAS oncogene family -0.0269168
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0268548
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0267957
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0266553
KIAA1549L KIAA1549-like -0.0260308
FOSL1 FOS-like antigen 1 -0.0257844
PRELID2 PRELI domain containing 2 -0.0257304
TBC1D22A TBC1 domain family, member 22A -0.0256811
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.025628
RIN2 Ras and Rab interactor 2 -0.0255411
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0254771
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0252112
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0250553
TNS3 tensin 3 -0.0250159
MACF1 microtubule-actin crosslinking factor 1 -0.0249013
ACTN1 actinin, alpha 1 -0.024694
BTBD10 BTB (POZ) domain containing 10 -0.0246894
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0243545
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0241502
EFNA5 ephrin-A5 -0.0240361
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.024004