S-Adenosyl-L-methionine (disulfate tosylate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0902415
INTS6 integrator complex subunit 6 0.0642724
NAV2 neuron navigator 2 0.0585439
TRIO trio Rho guanine nucleotide exchange factor 0.0553183
TLE4 transducin-like enhancer of split 4 0.0543451
POTEF POTE ankyrin domain family, member F 0.0537885
IGFBP3 insulin-like growth factor binding protein 3 0.0529889
EXT1 exostosin glycosyltransferase 1 0.0525477
ABI3BP ABI family, member 3 (NESH) binding protein 0.0489211
DEK DEK proto-oncogene 0.0488863
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0486447
SMAD3 SMAD family member 3 0.0476875
SLIT2 slit homolog 2 (Drosophila) 0.047451
FLNA filamin A, alpha 0.0461997
RAB7A RAB7A, member RAS oncogene family 0.0458653
ZSWIM6 zinc finger, SWIM-type containing 6 0.0454175
HSPH1 heat shock 105kDa/110kDa protein 1 0.0433893
NDRG1 N-myc downstream regulated 1 0.0419211
RPL35A ribosomal protein L35a 0.0418236
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0410121
NCOR2 nuclear receptor corepressor 2 0.0407054
VIM vimentin 0.0401755
RNF213 ring finger protein 213 0.0395075
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0381567
KRT7 keratin 7, type II 0.0380621
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0380192
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0361626
PLEC plectin 0.0358001
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0357541
DLG1 discs, large homolog 1 (Drosophila) 0.0354621
PTPRG protein tyrosine phosphatase, receptor type, G 0.0353037
ACTG1 actin gamma 1 0.0340724
TIMP2 TIMP metallopeptidase inhibitor 2 0.033747
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0333135
VCL vinculin 0.0332905
PCBP2 poly(rC) binding protein 2 0.0330558
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0328711
FUS FUS RNA binding protein 0.0324973
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0319328
GOLGB1 golgin B1 0.0314214
COL5A1 collagen, type V, alpha 1 0.0309344
KTN1 kinectin 1 (kinesin receptor) 0.0307654
CCDC80 coiled-coil domain containing 80 0.0306426
MYOF myoferlin 0.0304077
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0303414
COL7A1 collagen, type VII, alpha 1 0.0301843
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0300535
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0297142
CMIP c-Maf inducing protein 0.0296793
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0292529
PLSCR1 phospholipid scramblase 1 0.0289776
ANKRD11 ankyrin repeat domain 11 0.0287958
TPM1 tropomyosin 1 (alpha) 0.0287726
UBAP2 ubiquitin associated protein 2 0.0286311
SAMD4A sterile alpha motif domain containing 4A 0.0284436
FNIP1 folliculin interacting protein 1 0.0280204
SFPQ splicing factor proline/glutamine-rich 0.0277098
RND3 Rho family GTPase 3 0.027627
MYH9 myosin, heavy chain 9, non-muscle 0.0274023
SRRM2 serine/arginine repetitive matrix 2 0.0273862
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0272652
MAP4 microtubule-associated protein 4 0.0271836
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0271598
VEGFA vascular endothelial growth factor A 0.0267998
DSCAM Down syndrome cell adhesion molecule 0.0264286
KDM4C lysine (K)-specific demethylase 4C 0.026279
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0262595
SHB Src homology 2 domain containing adaptor protein B 0.0250518
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0250367
ATXN1 ataxin 1 0.0250173
IARS1 isoleucyl-tRNA synthetase 1 0.0247788
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0246882
TUFT1 tuftelin 1 0.0246206
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0243484
BRD4 bromodomain containing 4 0.0239534
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0236088
BRD2 bromodomain containing 2 0.0236017
DOCK5 dedicator of cytokinesis 5 0.0235758
DST dystonin 0.0235522
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0229533
CREBBP CREB binding protein 0.0227652
MYO1E myosin IE 0.0226617
PTK2 protein tyrosine kinase 2 0.0225534
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0225481
ERBIN erbb2 interacting protein 0.0223813
TENM3 teneurin transmembrane protein 3 0.0223178
RASAL2 RAS protein activator like 2 0.0222371
RPL7A ribosomal protein L7a 0.0221947
ASPH aspartate beta-hydroxylase 0.0221707
PRRC2B proline-rich coiled-coil 2B 0.0221368
VAV2 vav 2 guanine nucleotide exchange factor 0.0221325
PACS1 phosphofurin acidic cluster sorting protein 1 0.0220759
STC2 stanniocalcin 2 0.0220171
SND1 staphylococcal nuclease and tudor domain containing 1 0.0218095
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0216282
SQSTM1 sequestosome 1 0.021383
CEMIP2 cell migration inducing hyaluronidase 2 0.0213433
LPP LIM domain containing preferred translocation partner in lipoma 0.0212536
MSN moesin 0.0212482
SEPTIN9 septin 9 0.0212431

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.23844
MT2A metallothionein 2A -0.204519
FTH1 ferritin, heavy polypeptide 1 -0.112451
NAMPT nicotinamide phosphoribosyltransferase -0.0810767
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0808544
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0633429
LDHA lactate dehydrogenase A -0.0564399
B2M beta-2-microglobulin -0.0547506
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0522755
HLA-A major histocompatibility complex, class I, A -0.0512659
RAI14 retinoic acid induced 14 -0.0501572
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0487466
HLA-B major histocompatibility complex, class I, B -0.0470492
LOC112694756 uncharaterized LOC112694756 -0.0416221
HMGB2 high mobility group box 2 -0.0416058
ATP13A3 ATPase type 13A3 -0.0414043
ZNF841 zinc finger protein 841 -0.0413745
BZW1 basic leucine zipper and W2 domains 1 -0.0390918
PGK1 phosphoglycerate kinase 1 -0.038327
SET SET nuclear proto-oncogene -0.0372923
ENO1 enolase 1, (alpha) -0.0372087
OSMR oncostatin M receptor -0.0348952
CD44 CD44 molecule (Indian blood group) -0.0341116
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0328355
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0322135
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0310428
FNDC3B fibronectin type III domain containing 3B -0.0308912
HLA-C major histocompatibility complex, class I, C -0.0308189
SOD2 superoxide dismutase 2, mitochondrial -0.0304638
BASP1 brain abundant, membrane attached signal protein 1 -0.0304464
IFI6 interferon, alpha-inducible protein 6 -0.0303777
RPS3 ribosomal protein S3 -0.0302193
ANGPTL4 angiopoietin-like 4 -0.0298523
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0295908
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.027849
FN1 fibronectin 1 -0.0276841
ANKRD10 ankyrin repeat domain 10 -0.0260978
IL6ST interleukin 6 signal transducer -0.0258067
CDK17 cyclin-dependent kinase 17 -0.0244551
KLF6 Kruppel-like factor 6 -0.0244499
RPL12 ribosomal protein L12 -0.0241632
RPL26 ribosomal protein L26 -0.0237283
F3 coagulation factor III (thromboplastin, tissue factor) -0.0218095
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0212936
NRIP1 nuclear receptor interacting protein 1 -0.0210526
RACK1 receptor for activated C kinase 1 -0.0208138
RAD21 RAD21 homolog (S. pombe) -0.0207058
CD59 CD59 molecule, complement regulatory protein -0.0204537
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0201684
NPPB natriuretic peptide B -0.0199715
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0197088
MARCHF6 membrane associated ring-CH-type finger 6 -0.0196617
NT5E 5'-nucleotidase, ecto (CD73) -0.0193623
AKAP12 A kinase (PRKA) anchor protein 12 -0.0192492
NEK7 NIMA-related kinase 7 -0.0191899
TUBB4B tubulin, beta 4B class IVb -0.0187587
TMEM41B transmembrane protein 41B -0.0187044
TNIP1 TNFAIP3 interacting protein 1 -0.0182932
RPL30 ribosomal protein L30 -0.0178177
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0177635
GOLT1B golgi transport 1B -0.0175852
RAP1B RAP1B, member of RAS oncogene family -0.0175479
FAM162A family with sequence similarity 162, member A -0.0170483
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0166667
KIF5B kinesin family member 5B -0.0166133
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0165993
TPI1 triosephosphate isomerase 1 -0.0165915
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0164296
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0163078
PTBP3 polypyrimidine tract binding protein 3 -0.01626
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0155104
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0154666
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0153461
TMSB10 thymosin beta 10 -0.0152088
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -0.01481
SUB1 SUB1 homolog (S. cerevisiae) -0.0147563
RASA2 RAS p21 protein activator 2 -0.0147029
ZEB2 zinc finger E-box binding homeobox 2 -0.0146622
RRM1 ribonucleotide reductase M1 -0.0145332
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0144573
NPEPPS aminopeptidase puromycin sensitive -0.0144373
RPL11 ribosomal protein L11 -0.0143469
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.014197
RPS12 ribosomal protein S12 -0.0141382
GLIS3 GLIS family zinc finger 3 -0.0139926
FOXP1 forkhead box P1 -0.0139118
SSR1 signal sequence receptor, alpha -0.013726
RPS17 ribosomal protein S17 -0.013599
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.013553
CCL5 chemokine (C-C motif) ligand 5 -0.013442
NACA nascent polypeptide-associated complex alpha subunit -0.0134237
RPL35 ribosomal protein L35 -0.0134204
DTNA dystrobrevin, alpha -0.0133118
CANX calnexin -0.0132242
ABI2 abl-interactor 2 -0.0132062
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0131281
CALM3 calmodulin 3 (phosphorylase kinase, delta) -0.0131089
TPM3 tropomyosin 3 -0.0131051
PDCD10 programmed cell death 10 -0.0129714
RAB8B RAB8B, member RAS oncogene family -0.0129515