S-Adenosyl-L-methionine (disulfate tosylate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.0635565
ZSWIM6 zinc finger, SWIM-type containing 6 0.0617263
FAT1 FAT atypical cadherin 1 0.0613729
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.060339
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0581582
MYH9 myosin, heavy chain 9, non-muscle 0.0531636
MYO1E myosin IE 0.0531002
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0518145
EZR ezrin 0.0468114
EPS8 epidermal growth factor receptor pathway substrate 8 0.0465371
INTS6 integrator complex subunit 6 0.0457128
CTBP2 C-terminal binding protein 2 0.0449173
MSI2 musashi RNA-binding protein 2 0.0440891
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0423455
THSD4 thrombospondin, type I, domain containing 4 0.0416277
HSPA8 heat shock 70kDa protein 8 0.0400362
DSPP dentin sialophosphoprotein 0.0391395
RIMKLB ribosomal modification protein rimK-like family member B 0.0390004
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0384578
FLNB filamin B, beta 0.0375929
PRELID2 PRELI domain containing 2 0.0359593
PTPRK protein tyrosine phosphatase, receptor type, K 0.0358384
RNF213 ring finger protein 213 0.035757
PKM pyruvate kinase, muscle 0.0357427
PDE4D phosphodiesterase 4D, cAMP-specific 0.0341935
SERINC5 serine incorporator 5 0.0338125
MPRIP myosin phosphatase Rho interacting protein 0.032569
CCSER1 coiled-coil serine-rich protein 1 0.0325167
MYO5B myosin VB 0.0323565
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0319446
IGF1R insulin-like growth factor 1 receptor 0.0319088
GMDS GDP-mannose 4,6-dehydratase 0.0317553
LMO7 LIM domain 7 0.030917
RAD51B RAD51 paralog B 0.0309027
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.03073
PTPRG protein tyrosine phosphatase, receptor type, G 0.0305928
POTEF POTE ankyrin domain family, member F 0.0304706
ARHGAP26 Rho GTPase activating protein 26 0.0301055
FOXP1 forkhead box P1 0.0298857
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0293182
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0290391
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0288834
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0287607
EXT1 exostosin glycosyltransferase 1 0.028697
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0282917
CATSPERB catsper channel auxiliary subunit beta 0.028097
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0279975
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276734
ASPH aspartate beta-hydroxylase 0.027617
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.0275234
SMYD3 SET and MYND domain containing 3 0.0274556
PEAK1 pseudopodium-enriched atypical kinase 1 0.0272143
PCBP2 poly(rC) binding protein 2 0.0271944
ITGA6 integrin, alpha 6 0.0270976
TRAPPC9 trafficking protein particle complex 9 0.0269285
EEF2 eukaryotic translation elongation factor 2 0.0268297
EXOC4 exocyst complex component 4 0.0265444
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0257391
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0252956
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0251447
SFPQ splicing factor proline/glutamine-rich 0.0246126
ACTN4 actinin, alpha 4 0.0241068
LPP LIM domain containing preferred translocation partner in lipoma 0.0241051
SLTM SAFB-like, transcription modulator 0.0239859
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0237477
PDLIM5 PDZ and LIM domain 5 0.0234154
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0232002
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0231319
SP100 SP100 nuclear antigen 0.0230195
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0227132
MBNL1 muscleblind-like splicing regulator 1 0.0226857
PLEC plectin 0.0226696
DENND1A DENN/MADD domain containing 1A 0.0226539
WNK1 WNK lysine deficient protein kinase 1 0.0223934
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0222399
AKAP13 A kinase (PRKA) anchor protein 13 0.0220936
RPL3 ribosomal protein L3 0.0219761
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0215873
PARD3B par-3 family cell polarity regulator beta 0.021489
NCOR2 nuclear receptor corepressor 2 0.0214726
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0214284
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0211715
CEMIP cell migration inducing protein, hyaluronan binding 0.02113
LRPPRC leucine-rich pentatricopeptide repeat containing 0.021019
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0209122
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0208424
SMAD3 SMAD family member 3 0.0207201
LOC105378220 macrophage receptor MARCO-like 0.0206558
FHIT fragile histidine triad 0.0206187
DOCK5 dedicator of cytokinesis 5 0.0205729
SND1 staphylococcal nuclease and tudor domain containing 1 0.0205602
SPON1 spondin 1, extracellular matrix protein 0.0203166
DST dystonin 0.0201711
AHNAK AHNAK nucleoprotein 0.0198752
TRIO trio Rho guanine nucleotide exchange factor 0.0197869
ARL15 ADP-ribosylation factor-like 15 0.0197737
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0197058
FRMD5 FERM domain containing 5 0.0196835
CCND2 cyclin D2 0.0194212
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0193214

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.174535
RPLP1 ribosomal protein, large, P1 -0.112818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0814199
RPS8 ribosomal protein S8 -0.0790463
RPS6 ribosomal protein S6 -0.077562
RPLP0 ribosomal protein, large, P0 -0.0579322
RPS12 ribosomal protein S12 -0.0567298
RPL35A ribosomal protein L35a -0.0566812
RPL37A ribosomal protein L37a -0.0540255
RPL34 ribosomal protein L34 -0.0522812
PTMA prothymosin, alpha -0.0509094
RPL9 ribosomal protein L9 -0.0434238
RPS13 ribosomal protein S13 -0.0432604
RPL26 ribosomal protein L26 -0.0428683
RPL37 ribosomal protein L37 -0.0421868
PTPRR protein tyrosine phosphatase, receptor type, R -0.041025
RPS25 ribosomal protein S25 -0.0398449
RPLP2 ribosomal protein, large, P2 -0.0395793
RPS27A ribosomal protein S27a -0.0371375
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.036383
RPL31 ribosomal protein L31 -0.0363736
RPL38 ribosomal protein L38 -0.0330446
GOLGA4 golgin A4 -0.0326847
RPS19 ribosomal protein S19 -0.0318358
HLA-B major histocompatibility complex, class I, B -0.0307766
CALU calumenin -0.030685
RPL12 ribosomal protein L12 -0.0306096
RPS29 ribosomal protein S29 -0.0305916
RPS3 ribosomal protein S3 -0.0293109
RPS24 ribosomal protein S24 -0.0270156
RPL36 ribosomal protein L36 -0.0267123
RPS23 ribosomal protein S23 -0.0260802
TMSB10 thymosin beta 10 -0.0259958
RPS14 ribosomal protein S14 -0.0257325
RPS27 ribosomal protein S27 -0.0254282
RPL30 ribosomal protein L30 -0.0253609
RPL11 ribosomal protein L11 -0.0253531
EIF1 eukaryotic translation initiation factor 1 -0.0242004
RRBP1 ribosome binding protein 1 -0.0237453
IFI6 interferon, alpha-inducible protein 6 -0.0232204
RPL27A ribosomal protein L27a -0.0227079
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0223613
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0220137
RPL36A ribosomal protein L36a -0.0218868
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0216113
S100A6 S100 calcium binding protein A6 -0.0215927
TSPAN8 tetraspanin 8 -0.0215143
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.021484
RPL39 ribosomal protein L39 -0.0213993
GCC2 GRIP and coiled-coil domain containing 2 -0.0207611
RACK1 receptor for activated C kinase 1 -0.0203976
PDIA3 protein disulfide isomerase family A, member 3 -0.0203324
PLAC8 placenta-specific 8 -0.0202009
RPS16 ribosomal protein S16 -0.0201087
RPL7A ribosomal protein L7a -0.0193439
AGR2 anterior gradient 2 -0.0192385
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0190263
RPS10 ribosomal protein S10 -0.0189826
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0184108
SEC31A SEC31 homolog A (S. cerevisiae) -0.0181449
TPM4 tropomyosin 4 -0.0181303
RPS21 ribosomal protein S21 -0.0180611
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0178732
ACBD3 acyl-CoA binding domain containing 3 -0.0175967
RAB5A RAB5A, member RAS oncogene family -0.0173431
RPS20 ribosomal protein S20 -0.0168871
AKAP9 A kinase (PRKA) anchor protein 9 -0.0168324
IER3 immediate early response 3 -0.0168257
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0166398
RAB1A RAB1A, member RAS oncogene family -0.0164036
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0163838
GDF15 growth differentiation factor 15 -0.0161949
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0161928
NPSR1 neuropeptide S receptor 1 -0.0161131
S100A10 S100 calcium binding protein A10 -0.0156967
HLA-E major histocompatibility complex, class I, E -0.0155123
TMEM41B transmembrane protein 41B -0.0150235
RPL19 ribosomal protein L19 -0.015002
ISG15 ISG15 ubiquitin-like modifier -0.0149969
RPL8 ribosomal protein L8 -0.014645
VDAC1 voltage-dependent anion channel 1 -0.0145715
FTL ferritin, light polypeptide -0.0145088
RPS11 ribosomal protein S11 -0.0145086
EIF5B eukaryotic translation initiation factor 5B -0.0144673
SLK STE20-like kinase -0.0144497
MON2 MON2 homolog (S. cerevisiae) -0.0142802
TMEM263 transmembrane protein 263 -0.0141362
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0140418
KPNB1 karyopherin (importin) beta 1 -0.0139942
SRP54 signal recognition particle 54kDa -0.0138105
RPL35 ribosomal protein L35 -0.0137734
RIGI RNA sensor RIG-I -0.0136186
RPL7 ribosomal protein L7 -0.0134974
COPB1 coatomer protein complex, subunit beta 1 -0.0134743
TMF1 TATA element modulatory factor 1 -0.0134019
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0133719
EGR1 early growth response 1 -0.0133715
RPS15 ribosomal protein S15 -0.013344
SEC24D SEC24 family member D -0.0132386
TTC3 tetratricopeptide repeat domain 3 -0.0130637