S-Adenosyl-L-methionine (disulfate tosylate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM20C family with sequence similarity 20, member C 0.077069
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0766295
SMAD3 SMAD family member 3 0.0648331
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0618053
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0464069
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0462139
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0327704
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0317118
NCOA7 nuclear receptor coactivator 7 0.0317004
MT2A metallothionein 2A 0.0306024
GLCCI1 glucocorticoid induced 1 0.0275813
KSR1 kinase suppressor of ras 1 0.0275168
BASP1 brain abundant, membrane attached signal protein 1 0.0261483
COL7A1 collagen, type VII, alpha 1 0.0260092
INTS6 integrator complex subunit 6 0.0258811
NTN4 netrin 4 0.021634
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0214467
MIPOL1 mirror-image polydactyly 1 0.0212725
RBM39 RNA binding motif protein 39 0.0209938
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0203345
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0203299
OGA O-GlcNAcase 0.0196576
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0196083
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0191992
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0190007
MEIS1 Meis homeobox 1 0.0188423
HDAC4 histone deacetylase 4 0.0186187
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0185601
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0183791
C15ORF48 chromosome 15 open reading frame 48 0.0174135
HDLBP high density lipoprotein binding protein 0.0169026
NABP1 nucleic acid binding protein 1 0.0163295
BACE2 beta-site APP-cleaving enzyme 2 0.0151672
DSCAM Down syndrome cell adhesion molecule 0.0146378
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0144013
CCSER1 coiled-coil serine-rich protein 1 0.0140929
LRP1B low density lipoprotein receptor-related protein 1B 0.0136235
TTC28 tetratricopeptide repeat domain 28 0.0135078
EFNA5 ephrin-A5 0.0134647
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0134277
FLNA filamin A, alpha 0.0134071
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0132186
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0131701
UBASH3B ubiquitin associated and SH3 domain containing B 0.0131578
SAMD4A sterile alpha motif domain containing 4A 0.0131161
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0130457
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0129617
TBC1D5 TBC1 domain family, member 5 0.0129317
EXT1 exostosin glycosyltransferase 1 0.0129067
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0127943
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0127584
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0127241
CHD6 chromodomain helicase DNA binding protein 6 0.0126769
STK38L serine/threonine kinase 38 like 0.0126577
MICALL2 MICAL-like 2 0.01263
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0126299
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0126217
HEATR5A HEAT repeat containing 5A 0.0126065
CTNND1 catenin (cadherin-associated protein), delta 1 0.0125393
WDPCP WD repeat containing planar cell polarity effector 0.0124705
ZNF385D zinc finger protein 385D 0.0124285
MYO10 myosin X 0.0122133
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0121841
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0118989
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0117837
PDIA4 protein disulfide isomerase family A, member 4 0.011721
SMYD3 SET and MYND domain containing 3 0.0116063
GOLGA3 golgin A3 0.0115797
KCTD16 potassium channel tetramerization domain containing 16 0.0113851
RUNX1 runt-related transcription factor 1 0.0110452
CPNE1 copine I 0.0109551
CAPRIN2 caprin family member 2 0.0108582
RPL32 ribosomal protein L32 0.0105728
MARS1 methionyl-tRNA synthetase 1 0.0105205
TTLL10 tubulin tyrosine ligase-like family member 10 0.0105045
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0103871
FRMD5 FERM domain containing 5 0.0103345
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0103258
HTRA3 HtrA serine peptidase 3 0.010276
GSE1 Gse1 coiled-coil protein 0.0102494
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0101685
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.0101118
TASOR2 transcription activation suppressor family member 2 0.00999144
AFF1 AF4/FMR2 family, member 1 0.00995336
PMEPA1 prostate transmembrane protein, androgen induced 1 0.00994397
ARID5B AT rich interactive domain 5B (MRF1-like) 0.00989167
CHLSN cholesin 0.0098272
ACTN4 actinin, alpha 4 0.00976413
EIF3B eukaryotic translation initiation factor 3, subunit B 0.00966891
AVIL advillin 0.0096288
BLCAP bladder cancer associated protein 0.00961702
GPHN gephyrin 0.00956904
SH3KBP1 SH3-domain kinase binding protein 1 0.00956632
RPS21 ribosomal protein S21 0.00949895
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.00946299
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00945874
YBX3 Y box binding protein 3 0.00943082
ZEB1 zinc finger E-box binding homeobox 1 0.00939561
ANKRD36C ankyrin repeat domain 36C 0.00933668
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00933248

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.214696
VIM vimentin -0.146039
FN1 fibronectin 1 -0.137873
IGFBP3 insulin-like growth factor binding protein 3 -0.113215
PDE4D phosphodiesterase 4D, cAMP-specific -0.0957086
LOX lysyl oxidase -0.0955307
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0884881
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0871187
MEF2A myocyte enhancer factor 2A -0.0865838
STC1 stanniocalcin 1 -0.0797224
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0771691
SDK1 sidekick cell adhesion molecule 1 -0.074442
TMSB10 thymosin beta 10 -0.073716
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0726506
FTH1 ferritin, heavy polypeptide 1 -0.0695285
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0670697
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0668126
NDRG1 N-myc downstream regulated 1 -0.0661479
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0607862
TFPI2 tissue factor pathway inhibitor 2 -0.0599204
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0549585
ENO1 enolase 1, (alpha) -0.0520609
KTN1 kinectin 1 (kinesin receptor) -0.0518292
DPYD dihydropyrimidine dehydrogenase -0.0498006
S100A6 S100 calcium binding protein A6 -0.0492086
USP34 ubiquitin specific peptidase 34 -0.0491146
GRB10 growth factor receptor-bound protein 10 -0.0489034
CA12 carbonic anhydrase XII -0.0487322
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0477352
PSD3 pleckstrin and Sec7 domain containing 3 -0.0457717
FAM13A family with sequence similarity 13, member A -0.0456476
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0456325
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0440096
CDCP1 CUB domain containing protein 1 -0.0439485
AKAP13 A kinase (PRKA) anchor protein 13 -0.0437136
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0437001
EGR1 early growth response 1 -0.0432188
RAI14 retinoic acid induced 14 -0.0429244
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0428539
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0428133
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0428005
MTSS1 metastasis suppressor 1 -0.0424044
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0422943
GOLGA4 golgin A4 -0.0422581
KDM2A lysine (K)-specific demethylase 2A -0.0417009
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0414336
ZEB2 zinc finger E-box binding homeobox 2 -0.0409168
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0399998
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0392868
B2M beta-2-microglobulin -0.0391674
LDHA lactate dehydrogenase A -0.0387854
NRG1 neuregulin 1 -0.0379772
LOC102724023 ES1 protein homolog, mitochondrial -0.0376045
CDH13 cadherin 13 -0.0375231
ESYT2 extended synaptotagmin-like protein 2 -0.0368152
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0366131
ZMYND8 zinc finger, MYND-type containing 8 -0.0349611
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0334178
PKM pyruvate kinase, muscle -0.0334025
POTEF POTE ankyrin domain family, member F -0.0333817
MSRB3 methionine sulfoxide reductase B3 -0.0333419
CCDC88A coiled-coil domain containing 88A -0.0328733
BTG1 B-cell translocation gene 1, anti-proliferative -0.032763
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0324021
PYGL phosphorylase, glycogen, liver -0.0319105
PLIN2 perilipin 2 -0.0316162
FTL ferritin, light polypeptide -0.0313639
RIOK3 RIO kinase 3 -0.0303513
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0302631
ANGPTL4 angiopoietin-like 4 -0.0301383
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0295491
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0293995
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0291748
HMGA2 high mobility group AT-hook 2 -0.0290722
ENO2 enolase 2 (gamma, neuronal) -0.0289781
HMGA1 high mobility group AT-hook 1 -0.0286937
PCBP2 poly(rC) binding protein 2 -0.028639
MYADM myeloid-associated differentiation marker -0.0285235
DLG1 discs, large homolog 1 (Drosophila) -0.0284977
CLMP CXADR-like membrane protein -0.0281529
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0280729
DDIT3 DNA-damage-inducible transcript 3 -0.0278123
DTNA dystrobrevin, alpha -0.0277479
PDIA3 protein disulfide isomerase family A, member 3 -0.0275284
RAB1A RAB1A, member RAS oncogene family -0.0275151
DST dystonin -0.0274649
VEGFA vascular endothelial growth factor A -0.027456
OXR1 oxidation resistance 1 -0.0273743
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0273656
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0272421
OSMR oncostatin M receptor -0.0269636
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0264712
ARL4C ADP-ribosylation factor-like 4C -0.0263506
UBA6 ubiquitin-like modifier activating enzyme 6 -0.026246
JMJD1C jumonji domain containing 1C -0.026094
TMEM165 transmembrane protein 165 -0.0258931
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0257654
TMSB4X thymosin beta 4, X-linked -0.0256546
MAP1B microtubule-associated protein 1B -0.0254018
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0252798