S-Adenosyl-L-methionine (disulfate tosylate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF1R insulin-like growth factor 1 receptor 0.0975614
TXNRD1 thioredoxin reductase 1 0.0552162
RBM47 RNA binding motif protein 47 0.0543372
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0534941
MUC16 mucin 16, cell surface associated 0.0516863
SMOC1 SPARC related modular calcium binding 1 0.0512827
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0485217
MYO1E myosin IE 0.0464473
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0457519
AKAP12 A kinase (PRKA) anchor protein 12 0.0448817
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0441987
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.042703
MYOF myoferlin 0.0416943
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0412223
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0409124
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0401383
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0400567
CLIP1 CAP-GLY domain containing linker protein 1 0.0388089
PRELID2 PRELI domain containing 2 0.038085
FNDC3A fibronectin type III domain containing 3A 0.0378336
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0359786
BRD2 bromodomain containing 2 0.0358758
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0358378
AKAP9 A kinase (PRKA) anchor protein 9 0.0357581
AKR1C2 aldo-keto reductase family 1, member C2 0.0352548
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0352272
GDA guanine deaminase 0.0345053
INTS6 integrator complex subunit 6 0.0341656
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0338107
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0337423
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0335372
SOS1 son of sevenless homolog 1 (Drosophila) 0.0334196
LAMC2 laminin, gamma 2 0.0328938
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0322984
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0321363
WTAP Wilms tumor 1 associated protein 0.0320839
FUS FUS RNA binding protein 0.0318816
STS steroid sulfatase (microsomal), isozyme S 0.0313477
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0309588
DPYD dihydropyrimidine dehydrogenase 0.0307401
TBC1D22A TBC1 domain family, member 22A 0.0306222
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0304768
CAB39 calcium binding protein 39 0.0303485
IL1RN interleukin 1 receptor antagonist 0.0299689
AKR1C1 aldo-keto reductase family 1, member C1 0.029884
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.0298796
SAMD12 sterile alpha motif domain containing 12 0.0298296
MAST4 microtubule associated serine/threonine kinase family member 4 0.0295026
PTPRM protein tyrosine phosphatase, receptor type, M 0.0292052
RAB1A RAB1A, member RAS oncogene family 0.0284849
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0284397
LMO7 LIM domain 7 0.0284307
P3H2 prolyl 3-hydroxylase 2 0.0283352
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0282908
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.028252
CD109 CD109 molecule 0.0280692
ZSWIM6 zinc finger, SWIM-type containing 6 0.0278946
VCL vinculin 0.0277658
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0276334
MAPK8 mitogen-activated protein kinase 8 0.0274931
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0271594
CDH13 cadherin 13 0.0271015
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0270677
GMDS GDP-mannose 4,6-dehydratase 0.0269452
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0268388
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0264955
NPC1 Niemann-Pick disease, type C1 0.0262026
IER2 immediate early response 2 0.0261174
DDIT3 DNA-damage-inducible transcript 3 0.0259141
CCPG1 cell cycle progression 1 0.0257918
MB21D2 Mab-21 domain containing 2 0.025776
ARGLU1 arginine and glutamate rich 1 0.0257285
TMEM45B transmembrane protein 45B 0.0256006
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0253923
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0253683
C3ORF52 chromosome 3 open reading frame 52 0.0253589
TCP11L2 t-complex 11, testis-specific-like 2 0.0253213
ATF3 activating transcription factor 3 0.0252792
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0251381
USP43 ubiquitin specific peptidase 43 0.0250993
TACC2 transforming, acidic coiled-coil containing protein 2 0.0250826
RAI1 retinoic acid induced 1 0.0248641
GRAMD2B GRAM domain containing 2B 0.0248392
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 0.0248156
ATF6 activating transcription factor 6 0.0247793
TRAPPC9 trafficking protein particle complex 9 0.0247259
TC2N tandem C2 domains, nuclear 0.0247217
INO80 INO80 complex subunit 0.0244546
MAML3 mastermind-like 3 (Drosophila) 0.0243538
FNBP4 formin binding protein 4 0.0243068
USP53 ubiquitin specific peptidase 53 0.0242846
SQSTM1 sequestosome 1 0.0242784
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0240269
AHNAK2 AHNAK nucleoprotein 2 0.0239507
SETX senataxin 0.0239258
MARK4 MAP/microtubule affinity-regulating kinase 4 0.0239156
AAK1 AP2 associated kinase 1 0.0238399
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0238288
LAMB3 laminin, beta 3 0.0237405
UBN1 ubinuclein 1 0.0236785

decreased expression

Symbol Name Standardized Value
KRT17 keratin 17, type I -0.158574
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152314
NDRG1 N-myc downstream regulated 1 -0.107902
VIM vimentin -0.0951013
RPS6 ribosomal protein S6 -0.0900223
PTMA prothymosin, alpha -0.0814032
STC1 stanniocalcin 1 -0.0743455
IGFBP3 insulin-like growth factor binding protein 3 -0.0667544
TMSB10 thymosin beta 10 -0.0663664
POTEF POTE ankyrin domain family, member F -0.0660822
EIF1 eukaryotic translation initiation factor 1 -0.0612475
MCL1 myeloid cell leukemia 1 -0.059693
RPS19 ribosomal protein S19 -0.0551199
B2M beta-2-microglobulin -0.0551048
EEF2 eukaryotic translation elongation factor 2 -0.0549277
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.052029
RPLP1 ribosomal protein, large, P1 -0.0515937
HLA-B major histocompatibility complex, class I, B -0.0511384
NAMPT nicotinamide phosphoribosyltransferase -0.0509129
ANKRD12 ankyrin repeat domain 12 -0.0498125
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0495502
PKM pyruvate kinase, muscle -0.049363
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0488287
ENO1 enolase 1, (alpha) -0.0486562
MT2A metallothionein 2A -0.0481777
RPS12 ribosomal protein S12 -0.047641
LDHA lactate dehydrogenase A -0.0475467
FTH1 ferritin, heavy polypeptide 1 -0.0468748
FTL ferritin, light polypeptide -0.0466146
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0427291
CEMIP cell migration inducing protein, hyaluronan binding -0.0424389
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0422512
RTN4 reticulon 4 -0.0421388
RPL31 ribosomal protein L31 -0.0414939
LMAN1 lectin, mannose-binding, 1 -0.0411758
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0411385
RPL8 ribosomal protein L8 -0.0408873
NKD1 naked cuticle homolog 1 (Drosophila) -0.0403813
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0403272
ZNF292 zinc finger protein 292 -0.039553
COL6A3 collagen, type VI, alpha 3 -0.0389787
TPT1 tumor protein, translationally-controlled 1 -0.0389545
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0385541
PGK1 phosphoglycerate kinase 1 -0.0384079
ANXA1 annexin A1 -0.0375547
RPLP0 ribosomal protein, large, P0 -0.0373433
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0371276
RPL9 ribosomal protein L9 -0.0361255
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0360865
SRSF11 serine/arginine-rich splicing factor 11 -0.0360174
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0357734
DOCK5 dedicator of cytokinesis 5 -0.0353879
FN1 fibronectin 1 -0.0351552
RPL15 ribosomal protein L15 -0.0351413
GOLGB1 golgin B1 -0.0348289
RPS5 ribosomal protein S5 -0.0344218
SLC38A1 solute carrier family 38, member 1 -0.0341091
RPL11 ribosomal protein L11 -0.0338653
GOLGA4 golgin A4 -0.033834
AGO3 argonaute RISC catalytic component 3 -0.0331844
PDE4D phosphodiesterase 4D, cAMP-specific -0.0331647
ACTG1 actin gamma 1 -0.0329544
BTG1 B-cell translocation gene 1, anti-proliferative -0.0329375
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0325254
KLF5 Kruppel-like factor 5 (intestinal) -0.0323964
PTK2 protein tyrosine kinase 2 -0.0322985
RPL37A ribosomal protein L37a -0.0321377
ESYT2 extended synaptotagmin-like protein 2 -0.0321257
BZW1 basic leucine zipper and W2 domains 1 -0.0318631
USP33 ubiquitin specific peptidase 33 -0.0310963
CORO1C coronin, actin binding protein, 1C -0.031022
RPL23 ribosomal protein L23 -0.030827
PATJ PATJ crumbs cell polarity complex component -0.0304746
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0304099
RPLP2 ribosomal protein, large, P2 -0.0302128
RPS20 ribosomal protein S20 -0.0301064
SDC4 syndecan 4 -0.0299468
GNAS GNAS complex locus -0.029412
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0292785
FOXO3 forkhead box O3 -0.0290624
PLAUR plasminogen activator, urokinase receptor -0.0289366
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0288553
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0287465
KDM7A lysine (K)-specific demethylase 7A -0.0287441
STAU1 staufen double-stranded RNA binding protein 1 -0.0284393
RBM25 RNA binding motif protein 25 -0.0282227
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0281969
DDIT4 DNA-damage-inducible transcript 4 -0.028129
RPS8 ribosomal protein S8 -0.0280467
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0275472
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0274248
CALR calreticulin -0.0274056
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0272727
BIRC6 baculoviral IAP repeat containing 6 -0.0268734
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0266697
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0263215
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0262257
VEZT vezatin, adherens junctions transmembrane protein -0.0261173
SND1 staphylococcal nuclease and tudor domain containing 1 -0.026074
NIPBL Nipped-B homolog (Drosophila) -0.0257359