S-Adenosyl-L-methionine (disulfate tosylate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.121625
PDE4D phosphodiesterase 4D, cAMP-specific 0.0945681
ZNF608 zinc finger protein 608 0.0500591
UBC ubiquitin C 0.0496334
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0474354
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0365853
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0307991
SFPQ splicing factor proline/glutamine-rich 0.026188
KDM3A lysine (K)-specific demethylase 3A 0.0256479
TJP1 tight junction protein 1 0.0249881
HDAC9 histone deacetylase 9 0.024837
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0241869
YAP1 Yes-associated protein 1 0.0237922
DSCAM Down syndrome cell adhesion molecule 0.0236119
PDE4B phosphodiesterase 4B, cAMP-specific 0.0233344
EIF4A2 eukaryotic translation initiation factor 4A2 0.0226907
FLNB filamin B, beta 0.0213724
SAMD4A sterile alpha motif domain containing 4A 0.0209582
ZEB1 zinc finger E-box binding homeobox 1 0.0209167
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0204383
CAMTA1 calmodulin binding transcription activator 1 0.0203063
AMOTL2 angiomotin like 2 0.0203023
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0198151
ANXA1 annexin A1 0.0196862
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0193762
FAT1 FAT atypical cadherin 1 0.0188842
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0185532
EZR ezrin 0.0181667
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0178554
GSE1 Gse1 coiled-coil protein 0.0172443
HSPA8 heat shock 70kDa protein 8 0.0172156
ZFAND3 zinc finger, AN1-type domain 3 0.0169689
MYOF myoferlin 0.0168793
APP amyloid beta (A4) precursor protein 0.0167926
MACROD2 MACRO domain containing 2 0.0167525
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0166259
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0165491
PYGB phosphorylase, glycogen; brain 0.0164102
ZNF638 zinc finger protein 638 0.0163021
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0160436
CTBP2 C-terminal binding protein 2 0.0158077
ASCC3 activating signal cointegrator 1 complex subunit 3 0.015635
SGMS2 sphingomyelin synthase 2 0.0156131
CORO1C coronin, actin binding protein, 1C 0.0154405
JUN jun proto-oncogene 0.0154234
TOP2B topoisomerase (DNA) II beta 180kDa 0.0154
ECT2 epithelial cell transforming 2 0.0153635
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0153581
BMP2K BMP2 inducible kinase 0.0151544
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0148995
TBC1D22A TBC1 domain family, member 22A 0.0148843
DIDO1 death inducer-obliterator 1 0.0148038
ARID1A AT rich interactive domain 1A (SWI-like) 0.0147439
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0144473
DENND5A DENN/MADD domain containing 5A 0.0144453
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0143441
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.014001
NOTCH2 notch 2 0.0139993
EXT1 exostosin glycosyltransferase 1 0.0139096
GATA6 GATA binding protein 6 0.013879
ATP9B ATPase, class II, type 9B 0.0138336
ANKRD36 ankyrin repeat domain 36 0.0135399
PDGFC platelet derived growth factor C 0.0133046
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0131064
USP34 ubiquitin specific peptidase 34 0.0131002
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0130735
KDM4C lysine (K)-specific demethylase 4C 0.0130083
TACC2 transforming, acidic coiled-coil containing protein 2 0.0129984
FLNA filamin A, alpha 0.0128291
NCKAP1 NCK-associated protein 1 0.0124254
TRA2A transformer 2 alpha homolog (Drosophila) 0.0123432
PLPP3 phospholipid phosphatase 3 0.0122897
EIF4B eukaryotic translation initiation factor 4B 0.0121969
FER1L6 fer-1-like family member 6 0.0121714
GLI2 GLI family zinc finger 2 0.0121574
MACF1 microtubule-actin crosslinking factor 1 0.012116
ZC3H11A zinc finger CCCH-type containing 11A 0.011777
LMCD1 LIM and cysteine-rich domains 1 0.0116894
MYO5C myosin VC 0.0115575
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0115345
RBM33 RNA binding motif protein 33 0.0114774
CTNND1 catenin (cadherin-associated protein), delta 1 0.0113603
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.011359
HOOK2 hook microtubule-tethering protein 2 0.0113409
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0113088
CUL3 cullin 3 0.0112336
MCL1 myeloid cell leukemia 1 0.0112277
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0111737
AEBP2 AE binding protein 2 0.0111644
PEAK1 pseudopodium-enriched atypical kinase 1 0.0110976
SKI SKI proto-oncogene 0.0110931
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0110452
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0110294
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0110287
KDM4B lysine (K)-specific demethylase 4B 0.011014
CTTN cortactin 0.0110083
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0109734
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0109075
RAB21 RAB21, member RAS oncogene family 0.0108718
BLTP2 bridge-like lipid transfer protein family member 2 0.0108536

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.315522
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.303043
RPS6 ribosomal protein S6 -0.146721
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.11033
TPT1 tumor protein, translationally-controlled 1 -0.0983187
RPS8 ribosomal protein S8 -0.0971481
RPL35A ribosomal protein L35a -0.0919067
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0735629
RPLP1 ribosomal protein, large, P1 -0.0734632
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0727348
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0718636
RPLP0 ribosomal protein, large, P0 -0.0696522
RPS19 ribosomal protein S19 -0.0680466
ACTG1 actin gamma 1 -0.0656308
PFN1 profilin 1 -0.0637784
RPL12 ribosomal protein L12 -0.0636993
RPL11 ribosomal protein L11 -0.0631546
RPL31 ribosomal protein L31 -0.0618943
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0614471
RPL37A ribosomal protein L37a -0.0603436
HSPB1 heat shock 27kDa protein 1 -0.060204
B2M beta-2-microglobulin -0.0600494
RPS3 ribosomal protein S3 -0.0577747
RPL19 ribosomal protein L19 -0.0577273
RPL34 ribosomal protein L34 -0.0572113
RPS23 ribosomal protein S23 -0.0568561
RPL26 ribosomal protein L26 -0.0552009
PRDX2 peroxiredoxin 2 -0.0546454
FOXP1 forkhead box P1 -0.0534971
TMSB10 thymosin beta 10 -0.0531843
RPL9 ribosomal protein L9 -0.0518236
RPL36 ribosomal protein L36 -0.050696
TMSB4X thymosin beta 4, X-linked -0.0492585
NBEA neurobeachin -0.048967
ARL4C ADP-ribosylation factor-like 4C -0.0480381
RPS12 ribosomal protein S12 -0.0473239
RPS13 ribosomal protein S13 -0.0472677
FTL ferritin, light polypeptide -0.0467593
RPL32 ribosomal protein L32 -0.0460702
S100A6 S100 calcium binding protein A6 -0.0454595
S100A4 S100 calcium binding protein A4 -0.0447893
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0447606
RPL13A ribosomal protein L13a -0.0446916
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0438119
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0427057
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0419197
RPL7A ribosomal protein L7a -0.0416197
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0409178
RPLP2 ribosomal protein, large, P2 -0.0404607
S100A9 S100 calcium binding protein A9 -0.0404341
ENO2 enolase 2 (gamma, neuronal) -0.0394545
EIF1 eukaryotic translation initiation factor 1 -0.0386427
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0385532
RPS25 ribosomal protein S25 -0.0384039
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0383882
DLG1 discs, large homolog 1 (Drosophila) -0.0381059
POTEF POTE ankyrin domain family, member F -0.0380083
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0373958
RACK1 receptor for activated C kinase 1 -0.037136
DSTN destrin (actin depolymerizing factor) -0.0368397
RPS14 ribosomal protein S14 -0.0367693
RPL23 ribosomal protein L23 -0.0362925
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0360402
RPL27A ribosomal protein L27a -0.0357501
HMGA1 high mobility group AT-hook 1 -0.0355312
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0345974
RPS27 ribosomal protein S27 -0.0336321
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0336227
GNAS GNAS complex locus -0.0331238
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.032811
RPS11 ribosomal protein S11 -0.0325552
LDHA lactate dehydrogenase A -0.0325289
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0320386
ZBTB20 zinc finger and BTB domain containing 20 -0.032012
PGK1 phosphoglycerate kinase 1 -0.0318747
RPS29 ribosomal protein S29 -0.0312188
DPYD dihydropyrimidine dehydrogenase -0.0309328
ENO1 enolase 1, (alpha) -0.0308593
RPS17 ribosomal protein S17 -0.0307604
RPL7 ribosomal protein L7 -0.0307519
CENPF centromere protein F, 350/400kDa -0.0301766
NFIA nuclear factor I/A -0.0299735
RPL5 ribosomal protein L5 -0.0296917
RPS4X ribosomal protein S4, X-linked -0.0293657
SMC3 structural maintenance of chromosomes 3 -0.0292552
RPL8 ribosomal protein L8 -0.0292288
RPL10A ribosomal protein L10a -0.0290638
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0288281
RPS16 ribosomal protein S16 -0.0286142
MT2A metallothionein 2A -0.0286014
RPS24 ribosomal protein S24 -0.0285956
CCND1 cyclin D1 -0.028553
NAP1L1 nucleosome assembly protein 1-like 1 -0.0283704
MKI67 marker of proliferation Ki-67 -0.0282664
RPS21 ribosomal protein S21 -0.0282471
LOC102724023 ES1 protein homolog, mitochondrial -0.0279938
RPL37 ribosomal protein L37 -0.0275472
TUBB4B tubulin, beta 4B class IVb -0.0274021
RPL28 ribosomal protein L28 -0.0272112
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0271302