S-Adenosyl-L-methionine (disulfate tosylate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0761298
RBM39 RNA binding motif protein 39 0.0594216
ANKRD11 ankyrin repeat domain 11 0.0581223
IFRD1 interferon-related developmental regulator 1 0.0553611
PLEC plectin 0.0469699
KDM3A lysine (K)-specific demethylase 3A 0.0465673
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0448161
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0445515
ANKHD1 ankyrin repeat and KH domain containing 1 0.043916
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0422391
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.038422
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0362256
CTBP2 C-terminal binding protein 2 0.0354783
NCOA3 nuclear receptor coactivator 3 0.035299
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0350682
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0347697
TPT1 tumor protein, translationally-controlled 1 0.0342645
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0340818
EPS8 epidermal growth factor receptor pathway substrate 8 0.034043
TUFT1 tuftelin 1 0.0326407
INTS6 integrator complex subunit 6 0.0324
FUS FUS RNA binding protein 0.0323368
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0314416
FLNA filamin A, alpha 0.0295302
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0295004
TRA2A transformer 2 alpha homolog (Drosophila) 0.0292793
CUL3 cullin 3 0.0290729
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0281745
EXT1 exostosin glycosyltransferase 1 0.0279661
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0273086
SMAD3 SMAD family member 3 0.0270429
OGA O-GlcNAcase 0.0266137
ZFAND3 zinc finger, AN1-type domain 3 0.0262528
SPAG9 sperm associated antigen 9 0.0261711
IER3 immediate early response 3 0.0261107
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0260561
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0259324
SHB Src homology 2 domain containing adaptor protein B 0.0256129
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.025272
STX3 syntaxin 3 0.0252055
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0250919
MED13L mediator complex subunit 13-like 0.0245575
SPRED2 sprouty-related, EVH1 domain containing 2 0.0245178
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0241616
DIDO1 death inducer-obliterator 1 0.0241543
MARCHF6 membrane associated ring-CH-type finger 6 0.0230063
FAM107B family with sequence similarity 107, member B 0.0228715
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0227445
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0220448
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0219506
HBP1 HMG-box transcription factor 1 0.0217934
KDM6A lysine (K)-specific demethylase 6A 0.0217344
STAU1 staufen double-stranded RNA binding protein 1 0.0216923
MYH9 myosin, heavy chain 9, non-muscle 0.0216347
CTNND1 catenin (cadherin-associated protein), delta 1 0.0213517
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0213019
PUM2 pumilio RNA-binding family member 2 0.0211928
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0211112
CEMIP2 cell migration inducing hyaluronidase 2 0.0210763
MTMR3 myotubularin related protein 3 0.0210134
SND1 staphylococcal nuclease and tudor domain containing 1 0.0206087
USP3 ubiquitin specific peptidase 3 0.0205405
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0200331
TFRC transferrin receptor 0.0199245
RAB7A RAB7A, member RAS oncogene family 0.0198342
SAMD4A sterile alpha motif domain containing 4A 0.0196157
BLCAP bladder cancer associated protein 0.0193964
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0193902
USP9X ubiquitin specific peptidase 9, X-linked 0.0191727
UBE2H ubiquitin-conjugating enzyme E2H 0.0190854
RAB1A RAB1A, member RAS oncogene family 0.0190246
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0190108
ZFC3H1 zinc finger, C3H1-type containing 0.0189674
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0188679
SDC4 syndecan 4 0.0187428
DSCAM Down syndrome cell adhesion molecule 0.0185141
BIRC6 baculoviral IAP repeat containing 6 0.0184925
FBXO11 F-box protein 11 0.0184511
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0181607
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0181473
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0180752
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0180067
STX5 syntaxin 5 0.0179934
MEMO1 mediator of cell motility 1 0.0179745
PDIA5 protein disulfide isomerase family A, member 5 0.0179351
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0178954
RHEB Ras homolog enriched in brain 0.0178712
CDK13 cyclin-dependent kinase 13 0.0178333
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0177383
VCL vinculin 0.0176944
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0175659
HM13 histocompatibility (minor) 13 0.0174994
SENP5 SUMO1/sentrin specific peptidase 5 0.0172544
SRSF6 serine/arginine-rich splicing factor 6 0.0170901
ARHGAP26 Rho GTPase activating protein 26 0.0170897
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0170577
NUP98 nucleoporin 98kDa 0.0169673
AHNAK AHNAK nucleoprotein 0.0168184
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0166981
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0163942

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.216362
FTH1 ferritin, heavy polypeptide 1 -0.164901
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138527
MACC1 metastasis associated in colon cancer 1 -0.101751
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0963974
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0959008
TMSB10 thymosin beta 10 -0.0928025
RPL12 ribosomal protein L12 -0.0890017
B2M beta-2-microglobulin -0.085021
LDHA lactate dehydrogenase A -0.0813373
RPS6 ribosomal protein S6 -0.0785143
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0784117
LOC102724023 ES1 protein homolog, mitochondrial -0.0741728
KRT18 keratin 18, type I -0.069882
CST3 cystatin C -0.0692048
RPL18 ribosomal protein L18 -0.0658088
MAML2 mastermind-like 2 (Drosophila) -0.0598122
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0586225
RPS19 ribosomal protein S19 -0.0585787
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0574475
RPS12 ribosomal protein S12 -0.0567093
LOC112694756 uncharaterized LOC112694756 -0.0562789
RPS3 ribosomal protein S3 -0.0553482
KRT8 keratin 8, type II -0.0527454
RPL23 ribosomal protein L23 -0.0502307
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0493194
RPS5 ribosomal protein S5 -0.0479625
KRT19 keratin 19, type I -0.0436611
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0434441
EGR1 early growth response 1 -0.0433506
RPLP0 ribosomal protein, large, P0 -0.0426045
ZBTB20 zinc finger and BTB domain containing 20 -0.0421952
RPL19 ribosomal protein L19 -0.0421102
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.041574
RACK1 receptor for activated C kinase 1 -0.0414282
RPLP1 ribosomal protein, large, P1 -0.0410275
RPS14 ribosomal protein S14 -0.0408724
IFITM1 interferon induced transmembrane protein 1 -0.0406325
CBX3 chromobox homolog 3 -0.0403903
CLDN4 claudin 4 -0.0399779
RPL32 ribosomal protein L32 -0.0399156
GSTP1 glutathione S-transferase pi 1 -0.0371109
RPL36 ribosomal protein L36 -0.0361583
HMGA1 high mobility group AT-hook 1 -0.0354013
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0352302
PGK1 phosphoglycerate kinase 1 -0.0349023
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0344705
MKI67 marker of proliferation Ki-67 -0.0338348
PERP PERP, TP53 apoptosis effector -0.0334597
EIF1 eukaryotic translation initiation factor 1 -0.0333919
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0332564
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0330862
POTEF POTE ankyrin domain family, member F -0.0330842
RPL31 ribosomal protein L31 -0.0326329
SET SET nuclear proto-oncogene -0.0324612
RPL37A ribosomal protein L37a -0.0322954
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0315601
CENPF centromere protein F, 350/400kDa -0.0311599
TMSB4X thymosin beta 4, X-linked -0.0311082
PFN1 profilin 1 -0.030674
TBC1D5 TBC1 domain family, member 5 -0.0301717
SOX4 SRY (sex determining region Y)-box 4 -0.0299435
RPL28 ribosomal protein L28 -0.0298395
RPL8 ribosomal protein L8 -0.0295144
KTN1 kinectin 1 (kinesin receptor) -0.0295096
RPS4X ribosomal protein S4, X-linked -0.0294569
RPS17 ribosomal protein S17 -0.0290116
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0286436
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.028477
TMEM47 transmembrane protein 47 -0.0283885
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.028363
CLDN3 claudin 3 -0.0283621
ANXA2 annexin A2 -0.0283539
IFITM3 interferon induced transmembrane protein 3 -0.0278631
TMEM123 transmembrane protein 123 -0.0275067
RPL37 ribosomal protein L37 -0.0274748
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.0272427
FOSL1 FOS-like antigen 1 -0.0271959
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0270045
NCEH1 neutral cholesterol ester hydrolase 1 -0.026961
ATP5F1E ATP synthase F1 subunit epsilon -0.0269182
RPS13 ribosomal protein S13 -0.0267585
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0267057
HLA-A major histocompatibility complex, class I, A -0.0265818
PKM pyruvate kinase, muscle -0.0261453
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0261427
EPCAM epithelial cell adhesion molecule -0.0260922
RPL35 ribosomal protein L35 -0.0260445
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0259204
RPLP2 ribosomal protein, large, P2 -0.0258636
MYOF myoferlin -0.0256184
ESYT2 extended synaptotagmin-like protein 2 -0.0251895
RPS27 ribosomal protein S27 -0.0247509
EXOC4 exocyst complex component 4 -0.0245828
S100A6 S100 calcium binding protein A6 -0.0243363
IFI27 interferon, alpha-inducible protein 27 -0.0242283
SOX9 SRY (sex determining region Y)-box 9 -0.0241316
IFI6 interferon, alpha-inducible protein 6 -0.0241053
FAT1 FAT atypical cadherin 1 -0.0238856
RPS21 ribosomal protein S21 -0.023806