S-Adenosyl-L-methionine (disulfate tosylate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.0858027
TPT1 tumor protein, translationally-controlled 1 0.076131
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0617232
KLF5 Kruppel-like factor 5 (intestinal) 0.0488277
HSPA8 heat shock 70kDa protein 8 0.0422981
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0417244
VCL vinculin 0.0414901
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0412991
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0384472
LAMB3 laminin, beta 3 0.037128
DOCK5 dedicator of cytokinesis 5 0.0348894
ACTG1 actin gamma 1 0.034427
DOCK1 dedicator of cytokinesis 1 0.0335732
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0297286
FLOT1 flotillin 1 0.0296449
NTSR1 neurotensin receptor 1 (high affinity) 0.0293243
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0290975
RPS27A ribosomal protein S27a 0.0290203
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0273791
EXT1 exostosin glycosyltransferase 1 0.0260254
LAMC2 laminin, gamma 2 0.0254756
CDK13 cyclin-dependent kinase 13 0.0249976
KLC1 kinesin light chain 1 0.0240499
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0237749
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0231903
FERMT1 fermitin family member 1 0.0229027
ABR active BCR-related 0.0228221
CCSER1 coiled-coil serine-rich protein 1 0.0223552
RPL13A ribosomal protein L13a 0.0222805
FRMD8 FERM domain containing 8 0.0220004
MYO1D myosin ID 0.0218708
SEPTIN9 septin 9 0.0218277
TTC3 tetratricopeptide repeat domain 3 0.0212329
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0212134
LGALS12 lectin, galactoside-binding, soluble, 12 0.0209491
RPS29 ribosomal protein S29 0.0206302
MYO5B myosin VB 0.0205514
RPS25 ribosomal protein S25 0.0203833
RPS23 ribosomal protein S23 0.0203415
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0202049
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0201257
PLEC plectin 0.0199833
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0199244
HDAC4 histone deacetylase 4 0.0197651
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0196417
PRRC2B proline-rich coiled-coil 2B 0.0195546
COMMD10 COMM domain containing 10 0.0195442
ANKHD1 ankyrin repeat and KH domain containing 1 0.0194991
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0194509
ATL2 atlastin GTPase 2 0.0192971
STK4 serine/threonine kinase 4 0.0191331
LPP LIM domain containing preferred translocation partner in lipoma 0.0190716
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0188238
BICD1 bicaudal D homolog 1 (Drosophila) 0.0187824
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0185373
RPL7A ribosomal protein L7a 0.018443
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0183151
LYST lysosomal trafficking regulator 0.01823
CUX1 cut-like homeobox 1 0.0182209
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0181703
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0181192
ARL15 ADP-ribosylation factor-like 15 0.0179907
GOLGB1 golgin B1 0.0179686
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.017722
EXOC6B exocyst complex component 6B 0.0177096
ANKRD17 ankyrin repeat domain 17 0.0176128
EFNB2 ephrin-B2 0.0174843
RPL38 ribosomal protein L38 0.0173625
PMM2 phosphomannomutase 2 0.0173204
SNED1 sushi, nidogen and EGF-like domains 1 0.0173194
INTS6 integrator complex subunit 6 0.0171572
CDHR3 cadherin-related family member 3 0.0169369
GPATCH8 G patch domain containing 8 0.0168967
EXOC4 exocyst complex component 4 0.0168665
FBXO34 F-box protein 34 0.0167366
AHNAK AHNAK nucleoprotein 0.0164984
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.015989
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0159145
CCNH cyclin H 0.0158328
STAU2 staufen double-stranded RNA binding protein 2 0.0158101
NSD3 nuclear receptor binding SET domain protein 3 0.01574
WTAP Wilms tumor 1 associated protein 0.0157242
ATG7 autophagy related 7 0.015721
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0157038
S100A2 S100 calcium binding protein A2 0.0156367
XPO7 exportin 7 0.015591
FBXL17 F-box and leucine-rich repeat protein 17 0.0155452
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0.0155057
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0155049
AATF apoptosis antagonizing transcription factor 0.0153417
KLK6 kallikrein-related peptidase 6 0.0152385
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0151424
SENP5 SUMO1/sentrin specific peptidase 5 0.0150496
CFAP161 cilia and flagella associated protein 161 0.0149951
AKAP13 A kinase (PRKA) anchor protein 13 0.0147402
SAFB scaffold attachment factor B 0.0146472
RPS24 ribosomal protein S24 0.0145527
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0143875
FAF1 Fas (TNFRSF6) associated factor 1 0.0143682
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.014281

decreased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) -0.204697
AREG amphiregulin -0.149073
PTMA prothymosin, alpha -0.13599
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.128215
EGR1 early growth response 1 -0.113879
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.110657
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.101439
RPS6 ribosomal protein S6 -0.0931305
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0919166
TMSB10 thymosin beta 10 -0.089366
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0891062
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0875398
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0847696
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0829556
EZR ezrin -0.076058
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0758964
ANXA1 annexin A1 -0.075789
ESYT2 extended synaptotagmin-like protein 2 -0.0745509
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0711605
NDRG1 N-myc downstream regulated 1 -0.0708574
EEF2 eukaryotic translation elongation factor 2 -0.06692
HILPDA hypoxia inducible lipid droplet-associated -0.066462
OXR1 oxidation resistance 1 -0.0663613
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0637555
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0619043
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0587286
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0582017
FOSL1 FOS-like antigen 1 -0.0559406
GARS1 glycyl-tRNA synthetase 1 -0.0558031
TXNIP thioredoxin interacting protein -0.0555185
BIRC3 baculoviral IAP repeat containing 3 -0.052629
GOLGA4 golgin A4 -0.0524433
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0522891
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0514256
COG5 component of oligomeric golgi complex 5 -0.0507688
ANXA2 annexin A2 -0.0506457
RUNX2 runt-related transcription factor 2 -0.0503462
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0502034
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0499353
CLTC clathrin, heavy chain (Hc) -0.0498936
RREB1 ras responsive element binding protein 1 -0.0495173
SREBF2 sterol regulatory element binding transcription factor 2 -0.0493413
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0493264
FTH1 ferritin, heavy polypeptide 1 -0.0492257
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0480095
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0473458
PCBP2 poly(rC) binding protein 2 -0.0454808
FAM3C family with sequence similarity 3, member C -0.0452555
TXNRD1 thioredoxin reductase 1 -0.0452441
HMGA1 high mobility group AT-hook 1 -0.0452287
IGF2 insulin-like growth factor 2 -0.0448587
KMT2C lysine (K)-specific methyltransferase 2C -0.0441667
KTN1 kinectin 1 (kinesin receptor) -0.0434545
CD9 CD9 molecule -0.0433596
IARS1 isoleucyl-tRNA synthetase 1 -0.0426225
KMT2E lysine (K)-specific methyltransferase 2E -0.0424341
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0422827
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0421362
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0420208
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0414768
ZNF292 zinc finger protein 292 -0.0414291
NUP58 nucleoporin 58 -0.0413307
WAC WW domain containing adaptor with coiled-coil -0.0412831
PDE4B phosphodiesterase 4B, cAMP-specific -0.04105
CENPF centromere protein F, 350/400kDa -0.0410012
LGALS3 lectin, galactoside-binding, soluble, 3 -0.040942
MED13L mediator complex subunit 13-like -0.0406059
RBM25 RNA binding motif protein 25 -0.0405479
SLMAP sarcolemma associated protein -0.0398206
FMNL2 formin-like 2 -0.0397967
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0389772
LDHA lactate dehydrogenase A -0.0379607
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0376979
BAMBI BMP and activin membrane-bound inhibitor -0.0373702
NCOR1 nuclear receptor corepressor 1 -0.0373562
LOC102724023 ES1 protein homolog, mitochondrial -0.0372275
CBX3 chromobox homolog 3 -0.0358076
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0353286
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0349126
EMP1 epithelial membrane protein 1 -0.0343395
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0340924
EEF1G eukaryotic translation elongation factor 1 gamma -0.0339314
PERP PERP, TP53 apoptosis effector -0.0337593
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0335468
VMP1 vacuole membrane protein 1 -0.0335104
ZFP36 ZFP36 ring finger protein -0.0333505
USP3 ubiquitin specific peptidase 3 -0.0332403
SBF2 SET binding factor 2 -0.0331429
RAB6A RAB6A, member RAS oncogene family -0.03311
TOP1 topoisomerase (DNA) I -0.0325236
RPS2 ribosomal protein S2 -0.0325152
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0322139
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0320242
KIAA0040 KIAA0040 -0.0314671
RNF145 ring finger protein 145 -0.0313341
KLK10 kallikrein-related peptidase 10 -0.0313157
FAR1 fatty acyl CoA reductase 1 -0.0311915
BRWD1 bromodomain and WD repeat domain containing 1 -0.0309632
PRRC2C proline-rich coiled-coil 2C -0.0306979
FAM120A family with sequence similarity 120A -0.0306784