S-Adenosyl-L-methionine (disulfate tosylate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description S-Adenosyl-L-methionine (disulfate tosylate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the S-Adenosyl-L-methionine (disulfate tosylate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0639505
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0629449
ESYT2 extended synaptotagmin-like protein 2 0.0585193
OGA O-GlcNAcase 0.0492006
PLEC plectin 0.0483154
EEF2 eukaryotic translation elongation factor 2 0.0469715
EZR ezrin 0.0451513
CEMIP2 cell migration inducing hyaluronidase 2 0.0429563
MORF4L2 mortality factor 4 like 2 0.0409006
KMT2E lysine (K)-specific methyltransferase 2E 0.0404305
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0404238
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0402143
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0401965
MYH9 myosin, heavy chain 9, non-muscle 0.0368837
UBA6 ubiquitin-like modifier activating enzyme 6 0.0360005
GOLGA4 golgin A4 0.035211
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0348571
TTC3 tetratricopeptide repeat domain 3 0.0340622
DDIT4 DNA-damage-inducible transcript 4 0.0332138
KMT2C lysine (K)-specific methyltransferase 2C 0.0318491
CALU calumenin 0.0312484
SPRED2 sprouty-related, EVH1 domain containing 2 0.031222
ABHD2 abhydrolase domain containing 2 0.0310778
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0307385
HELZ helicase with zinc finger 0.0303148
RBM39 RNA binding motif protein 39 0.0294732
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0294677
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0293391
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0288079
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0285964
SETD5 SET domain containing 5 0.0284054
TRA2A transformer 2 alpha homolog (Drosophila) 0.0281783
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0279798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0276792
ERRFI1 ERBB receptor feedback inhibitor 1 0.0274148
PGK1 phosphoglycerate kinase 1 0.0267951
COPA coatomer protein complex, subunit alpha 0.026702
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0266061
ZNF292 zinc finger protein 292 0.0265985
PCM1 pericentriolar material 1 0.0259035
USP9X ubiquitin specific peptidase 9, X-linked 0.0257032
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0256075
COPB1 coatomer protein complex, subunit beta 1 0.0252992
NUP58 nucleoporin 58 0.0251591
EFNB2 ephrin-B2 0.0251551
SEC31A SEC31 homolog A (S. cerevisiae) 0.0249878
PDGFA platelet-derived growth factor alpha polypeptide 0.0249477
TMF1 TATA element modulatory factor 1 0.0249008
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.024676
ADAM17 ADAM metallopeptidase domain 17 0.024517
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0244723
BRWD3 bromodomain and WD repeat domain containing 3 0.0243696
PCLO piccolo presynaptic cytomatrix protein 0.0242423
RAB1A RAB1A, member RAS oncogene family 0.0241106
SMAD3 SMAD family member 3 0.0241061
GARS1 glycyl-tRNA synthetase 1 0.023893
DSCAM Down syndrome cell adhesion molecule 0.023891
HDLBP high density lipoprotein binding protein 0.0236292
TM9SF2 transmembrane 9 superfamily member 2 0.0234738
LMO7 LIM domain 7 0.0232361
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.023191
ACBD3 acyl-CoA binding domain containing 3 0.0230945
SVIL supervillin 0.0230399
DIAPH3 diaphanous-related formin 3 0.0229035
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0224803
JMJD1C jumonji domain containing 1C 0.0223676
XPO1 exportin 1 0.0221632
RLF rearranged L-myc fusion 0.0220672
ETNK1 ethanolamine kinase 1 0.0220169
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0218505
ANLN anillin, actin binding protein 0.021713
MARCHF6 membrane associated ring-CH-type finger 6 0.0217066
RICTOR RPTOR independent companion of MTOR, complex 2 0.0215629
RIOK3 RIO kinase 3 0.0215032
SUCO SUN domain containing ossification factor 0.0212529
RBM33 RNA binding motif protein 33 0.0211777
KDM6A lysine (K)-specific demethylase 6A 0.0211691
PDE8A phosphodiesterase 8A 0.02086
AFDN afadin, adherens junction formation factor 0.0205515
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0204621
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0203445
KDM3A lysine (K)-specific demethylase 3A 0.0202549
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019924
ARF4 ADP-ribosylation factor 4 0.0199175
SRP54 signal recognition particle 54kDa 0.0197819
COG5 component of oligomeric golgi complex 5 0.0197666
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0195855
RNF43 ring finger protein 43 0.0195062
GMCL1 germ cell-less, spermatogenesis associated 1 0.0194519
WDR45B WD repeat domain 45B 0.0193974
TBC1D23 TBC1 domain family, member 23 0.0193851
NDRG1 N-myc downstream regulated 1 0.0191624
USP3 ubiquitin specific peptidase 3 0.0191389
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0191339
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0190245
WDR26 WD repeat domain 26 0.0190176
RNMT RNA (guanine-7-) methyltransferase 0.0189905
SEC24A SEC24 family member A 0.0188797
TXNIP thioredoxin interacting protein 0.0186411
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0186324

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.285914
NKD1 naked cuticle homolog 1 (Drosophila) -0.150364
PTMA prothymosin, alpha -0.140861
CDH13 cadherin 13 -0.105136
NAV2 neuron navigator 2 -0.102504
CCND1 cyclin D1 -0.100143
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0987744
TPT1 tumor protein, translationally-controlled 1 -0.0922486
PDE4D phosphodiesterase 4D, cAMP-specific -0.0838807
TMSB10 thymosin beta 10 -0.0834999
SDK1 sidekick cell adhesion molecule 1 -0.0834158
VCL vinculin -0.0772687
MAML2 mastermind-like 2 (Drosophila) -0.0761177
RPL35A ribosomal protein L35a -0.075384
CDK6 cyclin-dependent kinase 6 -0.0700404
ZBTB20 zinc finger and BTB domain containing 20 -0.0694746
RPS6 ribosomal protein S6 -0.068455
ANO1 anoctamin 1, calcium activated chloride channel -0.0674037
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0653149
SKAP1 src kinase associated phosphoprotein 1 -0.064696
AKAP12 A kinase (PRKA) anchor protein 12 -0.0636842
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0632938
RAD51B RAD51 paralog B -0.06134
ADGRL2 adhesion G protein-coupled receptor L2 -0.0607461
RPS12 ribosomal protein S12 -0.0578377
RPL26 ribosomal protein L26 -0.0553815
RPL37A ribosomal protein L37a -0.0524105
RPS3 ribosomal protein S3 -0.0474134
RPS19 ribosomal protein S19 -0.0472399
HMGA1 high mobility group AT-hook 1 -0.0460703
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0459514
MRPS6 mitochondrial ribosomal protein S6 -0.0452593
NPAS2 neuronal PAS domain protein 2 -0.0448927
EXOC4 exocyst complex component 4 -0.0448531
RPL9 ribosomal protein L9 -0.0448478
WWOX WW domain containing oxidoreductase -0.0411308
ASPH aspartate beta-hydroxylase -0.0397515
RPS8 ribosomal protein S8 -0.0396848
RPL31 ribosomal protein L31 -0.0396553
RPL37 ribosomal protein L37 -0.0395268
ITGB4 integrin, beta 4 -0.0394358
GMDS GDP-mannose 4,6-dehydratase -0.0384458
SLC38A2 solute carrier family 38, member 2 -0.0373882
RPL23 ribosomal protein L23 -0.0370581
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0366239
KRT18 keratin 18, type I -0.0364012
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0361554
INTS6 integrator complex subunit 6 -0.0360865
RPS13 ribosomal protein S13 -0.036081
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0358268
FHIT fragile histidine triad -0.0347119
FLNB filamin B, beta -0.034446
RBP1 retinol binding protein 1, cellular -0.0343122
ACTG1 actin gamma 1 -0.0342301
SYT1 synaptotagmin I -0.0342287
TAS2R14 taste receptor, type 2, member 14 -0.034075
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0339552
RPS17 ribosomal protein S17 -0.0337275
FTH1 ferritin, heavy polypeptide 1 -0.0334349
FRMD5 FERM domain containing 5 -0.0333398
LPP LIM domain containing preferred translocation partner in lipoma -0.0330569
RPLP1 ribosomal protein, large, P1 -0.0330321
RPS27A ribosomal protein S27a -0.0328844
RABGAP1L RAB GTPase activating protein 1-like -0.03263
MT2A metallothionein 2A -0.0325418
FTL ferritin, light polypeptide -0.0324584
SET SET nuclear proto-oncogene -0.0319878
POTEF POTE ankyrin domain family, member F -0.0315115
PCDH9 protocadherin 9 -0.0312313
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0311631
LDHA lactate dehydrogenase A -0.0309705
BCL2L1 BCL2-like 1 -0.0299217
ANXA3 annexin A3 -0.0298464
RPLP2 ribosomal protein, large, P2 -0.0296418
RPS24 ribosomal protein S24 -0.0296031
CBX3 chromobox homolog 3 -0.0295017
NTSR1 neurotensin receptor 1 (high affinity) -0.0294381
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0292974
VIM vimentin -0.0289968
PATJ PATJ crumbs cell polarity complex component -0.0289748
TUBB4B tubulin, beta 4B class IVb -0.028935
CBX5 chromobox homolog 5 -0.0288705
UBAP2 ubiquitin associated protein 2 -0.02879
EIF5B eukaryotic translation initiation factor 5B -0.0285126
PHF14 PHD finger protein 14 -0.0281783
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0280023
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0279904
BACE2 beta-site APP-cleaving enzyme 2 -0.0278968
PFN1 profilin 1 -0.0273109
IGF2 insulin-like growth factor 2 -0.0272821
RPS14 ribosomal protein S14 -0.0272574
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0272032
ENO1 enolase 1, (alpha) -0.0270604
MYOF myoferlin -0.0268313
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0265817
NCEH1 neutral cholesterol ester hydrolase 1 -0.0262891
HMGB1 high mobility group box 1 -0.0261876
AIG1 androgen-induced 1 -0.0259487
CUX1 cut-like homeobox 1 -0.0258638
DNAH14 dynein, axonemal, heavy chain 14 -0.0257776