S-propranolol-5444 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the S-propranolol-5444 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AFF3 AF4/FMR2 family, member 3
AMPH amphiphysin
ANGEL2 angel homolog 2 (Drosophila)
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
BCL2A1 BCL2-related protein A1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BMP5 bone morphogenetic protein 5
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C14ORF79 chromosome 14 open reading frame 79
C5AR2 complement component 5a receptor 2
CD3D CD3d molecule, delta (CD3-TCR complex)
CEP41 centrosomal protein 41kDa
COMT catechol-O-methyltransferase
CORO7 coronin 7
CPQ carboxypeptidase Q
CREM cAMP responsive element modulator
CSTA cystatin A (stefin A)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DCBLD2 discoidin, CUB and LCCL domain containing 2
DFNB31 deafness, autosomal recessive 31
DGCR2 DiGeorge syndrome critical region gene 2
DIO2 deiodinase, iodothyronine, type II
DOK4 docking protein 4
EXPH5 exophilin 5
F2R coagulation factor II (thrombin) receptor
FAM46C family with sequence similarity 46, member C
FBXL7 F-box and leucine-rich repeat protein 7
FGFR1 fibroblast growth factor receptor 1
FMO5 flavin containing monooxygenase 5
FOXN3 forkhead box N3
GK glycerol kinase
GM2A GM2 ganglioside activator
GPR22 G protein-coupled receptor 22
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HIST1H2BN histone cluster 1, H2bn
IGFBP5 insulin-like growth factor binding protein 5
IQSEC2 IQ motif and Sec7 domain 2
IRS2 insulin receptor substrate 2
KDM8 lysine (K)-specific demethylase 8
LIME1 Lck interacting transmembrane adaptor 1
LINC00216 long intergenic non-protein coding RNA 216
LMNA lamin A/C
MFAP3L microfibrillar-associated protein 3-like
MON2 MON2 homolog (S. cerevisiae)
MST1 macrophage stimulating 1
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFIB nuclear factor I/B
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRF1 nuclear respiratory factor 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OAZ3 ornithine decarboxylase antizyme 3
OGDHL oxoglutarate dehydrogenase-like
OSBPL10 oxysterol binding protein-like 10
PCDH11Y protocadherin 11 Y-linked
PLAU plasminogen activator, urokinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK3 polo-like kinase 3
PLTP phospholipid transfer protein
POLM polymerase (DNA directed), mu
PPP4R4 protein phosphatase 4, regulatory subunit 4
RAD52 RAD52 homolog (S. cerevisiae)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS14 regulator of G-protein signaling 14
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPH3A rabphilin 3A
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCAI suppressor of cancer cell invasion
SETD1B SET domain containing 1B
SH3BP2 SH3-domain binding protein 2
SLC16A4 solute carrier family 16, member 4
SLC22A14 solute carrier family 22, member 14
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMAD4 SMAD family member 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STXBP6 syntaxin binding protein 6 (amisyn)
TECPR2 tectonin beta-propeller repeat containing 2
TICAM1 toll-like receptor adaptor molecule 1
TK2 thymidine kinase 2, mitochondrial
WNK1 WNK lysine deficient protein kinase 1
ZER1 zyg-11 related, cell cycle regulator
ZNF506 zinc finger protein 506
ZNF552 zinc finger protein 552
ZNF76 zinc finger protein 76
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
AOC2 amine oxidase, copper containing 2 (retina-specific)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATP10D ATPase, class V, type 10D
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BCO1 beta-carotene oxygenase 1
BHLHE41 basic helix-loop-helix family, member e41
BIRC7 baculoviral IAP repeat containing 7
C10ORF95 chromosome 10 open reading frame 95
C2ORF27A chromosome 2 open reading frame 27A
C8ORF44 chromosome 8 open reading frame 44
CAPN5 calpain 5
CCNO cyclin O
CD79B CD79b molecule, immunoglobulin-associated beta
CNR2 cannabinoid receptor 2 (macrophage)
CSF1R colony stimulating factor 1 receptor
CUEDC1 CUE domain containing 1
CXXC4 CXXC finger protein 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DIO1 deiodinase, iodothyronine, type I
DMTN dematin actin binding protein
DOCK1 dedicator of cytokinesis 1
DUSP2 dual specificity phosphatase 2
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM53B family with sequence similarity 53, member B
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
FLJ22184
GLRA1 glycine receptor, alpha 1
HCAR3 hydroxycarboxylic acid receptor 3
HHAT hedgehog acyltransferase
HOXC5 homeobox C5
IGFBP6 insulin-like growth factor binding protein 6
IRF1 interferon regulatory factor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JMJD4 jumonji domain containing 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0754 KIAA0754
LAMC3 laminin, gamma 3
LHX1 LIM homeobox 1
LRP3 low density lipoprotein receptor-related protein 3
LRRC37A3 leucine rich repeat containing 37, member A3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAST3 microtubule associated serine/threonine kinase 3
MCTP1 multiple C2 domains, transmembrane 1
MEFV Mediterranean fever
N4BP3 NEDD4 binding protein 3
NPTX1 neuronal pentraxin I
OLFML2A olfactomedin-like 2A
ONECUT2 one cut homeobox 2
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OSGIN1 oxidative stress induced growth inhibitor 1
PCDH12 protocadherin 12
PCDHGA10 protocadherin gamma subfamily A, 10
PDE12 phosphodiesterase 12
PDE8B phosphodiesterase 8B
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PLD2 phospholipase D2
PODNL1 podocan-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFXAP regulatory factor X-associated protein
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIN1 Ras and Rab interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
STRA6 stimulated by retinoic acid 6
TBL1Y transducin (beta)-like 1, Y-linked
TBX19 T-box 19
TCTN2 tectonic family member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM19 transmembrane protein 19
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRAIP TRAF interacting protein
TRIM21 tripartite motif containing 21
TRIM66 tripartite motif containing 66
TSGA10 testis specific, 10
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
VPS9D1 VPS9 domain containing 1
WDR62 WD repeat domain 62
ZNF136 zinc finger protein 136
ZNF197 zinc finger protein 197
ZNF304 zinc finger protein 304
ZNF324 zinc finger protein 324
ZNF446 zinc finger protein 446
ZNF747 zinc finger protein 747