S0-EE-Y7IR_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, 4-(((6S,9AS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate, Wnt signaling inhibitor, Inhibitor of beta-catenin/TCF transcription targeting CTNNB1 (Novartis, 71509159)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/71509159
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Genes

59 genes differentially expressed following the S0-EE-Y7IR_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MCM4 minichromosome maintenance complex component 4 0.875675
C19ORF33 chromosome 19 open reading frame 33 0.737838
RPLP2 ribosomal protein, large, P2 0.702176
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 0.629762
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.520427
RPS9 ribosomal protein S9 0.449833
ANXA2 annexin A2 0.449833
KRT17 keratin 17, type I 0.411749
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.411749
RPL35 ribosomal protein L35 0.406426
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.403713
PHPT1 phosphohistidine phosphatase 1 0.395288
SNRPC small nuclear ribonucleoprotein polypeptide C 0.348482
MYL12B myosin, light chain 12B, regulatory 0.348482
COX5B cytochrome c oxidase subunit Vb 0.346008
LGALS1 lectin, galactoside-binding, soluble, 1 0.342874
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.341316
RPS5 ribosomal protein S5 0.331419
UBB ubiquitin B 0.331419
TIMP1 TIMP metallopeptidase inhibitor 1 0.330077
UBL5 ubiquitin-like 5 0.324699
RPL37A ribosomal protein L37a 0.316132
COX7C cytochrome c oxidase subunit VIIc 0.316132
RPS21 ribosomal protein S21 0.288579
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.273029
ROMO1 reactive oxygen species modulator 1 0.273029
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.26134
MRPL14 mitochondrial ribosomal protein L14 0.261019
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.261019
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.256982
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.256147
RPS27 ribosomal protein S27 0.25438
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.253836
CD63 CD63 molecule 0.253836
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.25173
WDR54 WD repeat domain 54 0.25173
LOC112694756 uncharaterized LOC112694756 0.25173
RPL38 ribosomal protein L38 0.248972
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.244116
RPS15 ribosomal protein S15 0.244116
TUBB4B tubulin, beta 4B class IVb 0.243431
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.233307
UBC ubiquitin C 0.232999
RPS3 ribosomal protein S3 0.230317
TRIM56 tripartite motif containing 56 0.226725
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 0.215632
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.20992
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.209642
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.208741
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.208128
TUBA1B tubulin, alpha 1b 0.204444
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 0.20171
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.200787

decreased expression

Symbol Name Standardized Value
TIMM29 translocase of inner mitochondrial membrane 29 -0.524581
EXOC7 exocyst complex component 7 -0.520427
CENPVL3 centromere protein V like 3 -0.289172
ADGRD1 adhesion G protein-coupled receptor D1 -0.232999
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -0.222629
TLN1 talin 1 -0.200062