S0-EE-Y7IR_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, 4-(((6S,9AS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate, Wnt signaling inhibitor, Inhibitor of beta-catenin/TCF transcription targeting CTNNB1 (Novartis, 71509159)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/71509159
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Genes

26 genes differentially expressed following the S0-EE-Y7IR_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 2.15506
MCM4 minichromosome maintenance complex component 4 1.16635
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.03321
TRIM56 tripartite motif containing 56 0.960666
RPLP2 ribosomal protein, large, P2 0.960666
RHOG ras homolog family member G 0.950378
KRT81 keratin 81, type II 0.870881
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.668622
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.470293
C19ORF33 chromosome 19 open reading frame 33 0.458399
LMNA lamin A/C 0.336683
TAGLN transgelin 0.316722
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.316722
RPS5 ribosomal protein S5 0.295113
GPS1 G protein pathway suppressor 1 0.289336
HSPB1 heat shock 27kDa protein 1 0.289336
KRT17 keratin 17, type I 0.28742
RPS27 ribosomal protein S27 0.274569
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.262504
PHPT1 phosphohistidine phosphatase 1 0.224136
ATOX1 antioxidant 1 copper chaperone 0.219087
TNNI3 troponin I type 3 (cardiac) 0.204162

decreased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.581642
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.250803
NME1-NME2 NME1-NME2 readthrough -0.216529
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.201278