S0-EE-YAXR_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, 6-Nonylpyridine-2,4-diol, GPR84 agonist;Potent GPR84 Agonists targeting GPR84 (Novartis, 127045422)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/127045422
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Genes

54 genes differentially expressed following the S0-EE-YAXR_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
BUD31 BUD31 homolog (S. cerevisiae) 0.775277
UBB ubiquitin B 0.750165
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.742782
RPS5 ribosomal protein S5 0.689463
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.417412
RPL37A ribosomal protein L37a 0.376819
RPL18 ribosomal protein L18 0.376819
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.362752
DDTL D-dopachrome tautomerase-like 0.344911
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.333012
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 0.333012
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.333012
TNNT1 troponin T type 1 (skeletal, slow) 0.333012
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 0.331343
ATOX1 antioxidant 1 copper chaperone 0.319888
KRT17 keratin 17, type I 0.319888
LGALS1 lectin, galactoside-binding, soluble, 1 0.318802
MRPL14 mitochondrial ribosomal protein L14 0.30662
RPL35A ribosomal protein L35a 0.266457
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.263216
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 0.25392
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.253242
RPS9 ribosomal protein S9 0.252663
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.252405
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.252405
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.250921
BOP1 block of proliferation 1 0.247524
MFGE8 milk fat globule-EGF factor 8 protein 0.24365
TPM2 tropomyosin 2 (beta) 0.24365
RPLP2 ribosomal protein, large, P2 0.233794
NF2 neurofibromin 2 (merlin) 0.233794
TUFM Tu translation elongation factor, mitochondrial 0.231834
RERGL RERG/RAS-like 0.226197
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.225197
RPL8 ribosomal protein L8 0.217402
HSPB1 heat shock 27kDa protein 1 0.214053
CST3 cystatin C 0.21122
ATP5MF ATP synthase membrane subunit f 0.21122
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.210009
C19ORF33 chromosome 19 open reading frame 33 0.209412
TMEM205 transmembrane protein 205 0.205533

decreased expression

Symbol Name Standardized Value
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -0.41096
TMEM41A transmembrane protein 41A -0.382976
CAPN15 calpain 15 -0.355416
PNMA2 paraneoplastic Ma antigen 2 -0.333012
ADGRA3 adhesion G protein-coupled receptor A3 -0.299916
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.290966
C2ORF42 chromosome 2 open reading frame 42 -0.289835
COPS7A COP9 signalosome subunit 7A -0.255934
TPT1 tumor protein, translationally-controlled 1 -0.23214
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.229216
CNN3 calponin 3, acidic -0.226197
IFNAR2 interferon (alpha, beta and omega) receptor 2 -0.225496
EIF1 eukaryotic translation initiation factor 1 -0.209412