S0-EE-YAXR_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, 6-Nonylpyridine-2,4-diol, GPR84 agonist;Potent GPR84 Agonists targeting GPR84 (Novartis, 127045422)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/127045422
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Genes

149 genes differentially expressed following the S0-EE-YAXR_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
BUD31 BUD31 homolog (S. cerevisiae) 2.26604
RPS5 ribosomal protein S5 1.21938
RPS15 ribosomal protein S15 0.958497
TAGLN transgelin 0.844942
ROMO1 reactive oxygen species modulator 1 0.814633
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.802557
RPL37A ribosomal protein L37a 0.757983
UBC ubiquitin C 0.706783
DDTL D-dopachrome tautomerase-like 0.667454
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.640495
RPS27 ribosomal protein S27 0.639381
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.637635
TBCB tubulin folding cofactor B 0.594108
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.546758
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.517661
BLVRB biliverdin reductase B 0.501813
MYL12B myosin, light chain 12B, regulatory 0.479243
ATOX1 antioxidant 1 copper chaperone 0.459386
MICALL1 MICAL-like 1 0.441619
MLF2 myeloid leukemia factor 2 0.424994
BOP1 block of proliferation 1 0.416016
TAGLN2 transgelin 2 0.390313
RPL18A ribosomal protein L18a 0.375356
RPL18 ribosomal protein L18 0.375356
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.373974
FBXW5 F-box and WD repeat domain containing 5 0.354116
P4HB prolyl 4-hydroxylase, beta polypeptide 0.35401
SIGMAR1 sigma non-opioid intracellular receptor 1 0.353287
PPIAP39 peptidylprolyl isomerase A pseudogene 39 0.34667
KRT17 keratin 17, type I 0.339417
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.336641
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.334576
MFGE8 milk fat globule-EGF factor 8 protein 0.325842
TNNT1 troponin T type 1 (skeletal, slow) 0.321337
MRPL13 mitochondrial ribosomal protein L13 0.315046
UNC13D unc-13 homolog D (C. elegans) 0.314232
RPS29 ribosomal protein S29 0.314232
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.310871
KRT18 keratin 18, type I 0.309097
HSPB1 heat shock 27kDa protein 1 0.30874
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.307982
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.305692
RPLP2 ribosomal protein, large, P2 0.302114
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.299148
PTGES2 prostaglandin E synthase 2 0.299148
NF2 neurofibromin 2 (merlin) 0.294416
ATP5MF ATP synthase membrane subunit f 0.291008
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.289047
HDGF hepatoma-derived growth factor 0.28683
PYCR1 pyrroline-5-carboxylate reductase 1 0.2815
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.273787
RPS7 ribosomal protein S7 0.273262
HMGA1 high mobility group AT-hook 1 0.272744
GSTP1 glutathione S-transferase pi 1 0.271942
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.269621
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.269369
IFITM3 interferon induced transmembrane protein 3 0.269268
PGRMC2 progesterone receptor membrane component 2 0.268408
HSPA4 heat shock 70kDa protein 4 0.262483
YDJC YdjC homolog (bacterial) 0.255967
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.246652
OLFML3 olfactomedin-like 3 0.242598
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.238824
DMKN dermokine 0.238591
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.23684
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.235018
TNNI3 troponin I type 3 (cardiac) 0.232845
ZFPM1 zinc finger protein, FOG family member 1 0.229292
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.227684
ZNRD2 zinc ribbon domain containing 2 0.22705
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.225376
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.225376
SHISA5 shisa family member 5 0.223326
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.221372
LMNA lamin A/C 0.219179
AGTRAP angiotensin II receptor-associated protein 0.216562
PLEC plectin 0.215924
TMEM9 transmembrane protein 9 0.212093
MAP7D1 MAP7 domain containing 1 0.209644
CBX1 chromobox homolog 1 0.209644
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.208414
TRIM15 tripartite motif containing 15 0.208351
RPL15 ribosomal protein L15 0.207983
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.206853
BRCA1 breast cancer 1, early onset 0.206682
IPO4 importin 4 0.205052

decreased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -1.14572
ACTG1 actin gamma 1 -0.640495
EIF1 eukaryotic translation initiation factor 1 -0.539066
FTH1 ferritin, heavy polypeptide 1 -0.534035
TPT1 tumor protein, translationally-controlled 1 -0.451096
C1ORF43 chromosome 1 open reading frame 43 -0.390313
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.375356
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.34667
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -0.344511
JTB jumping translocation breakpoint -0.341752
SUMO2 small ubiquitin-like modifier 2 -0.339417
RPS28 ribosomal protein S28 -0.339417
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -0.339417
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.337534
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.328587
TMEM98 transmembrane protein 98 -0.32765
RPL27A ribosomal protein L27a -0.31157
PKM pyruvate kinase, muscle -0.30874
NTAN1 N-terminal asparagine amidase -0.301751
RPL4 ribosomal protein L4 -0.300127
WDR45B WD repeat domain 45B -0.297807
LRRC37B leucine rich repeat containing 37B -0.297014
MAGED1 melanoma antigen family D1 -0.295424
ERH enhancer of rudimentary homolog (Drosophila) -0.292668
DPH3 diphthamide biosynthesis 3 -0.281301
RPS20 ribosomal protein S20 -0.269268
CDK4 cyclin-dependent kinase 4 -0.263127
NENF neudesin neurotrophic factor -0.262957
RAB43 RAB43, member RAS oncogene family -0.262914
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.262483
TMEM230 transmembrane protein 230 -0.262483
FSTL1 follistatin-like 1 -0.258493
SLC66A2 solute carrier family 66 member 2 -0.256673
RPS8 ribosomal protein S8 -0.256311
TRIR telomerase RNA component interacting RNase -0.249799
MCM3 minichromosome maintenance complex component 3 -0.249799
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -0.246417
NME1-NME2 NME1-NME2 readthrough -0.245074
STMN1 stathmin 1 -0.243589
RPL10A ribosomal protein L10a -0.242598
C1ORF174 chromosome 1 open reading frame 174 -0.24051
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.239886
STAMBP STAM binding protein -0.239064
MTCH1 mitochondrial carrier 1 -0.238853
SMIM8 small integral membrane protein 8 -0.23684
HDAC1 histone deacetylase 1 -0.235018
FAM168B family with sequence similarity 168, member B -0.232845
FEN1 flap structure-specific endonuclease 1 -0.232779
PCLAF PCNA clamp associated factor -0.231481
CCN2 cellular communication network factor 2 -0.230877
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -0.229568
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.227827
TARDBP TAR DNA binding protein -0.224656
IMMT inner membrane protein, mitochondrial -0.221946
ILF2 interleukin enhancer binding factor 2 -0.221162
TRIM39 tripartite motif containing 39 -0.221162
ACTN1 actinin, alpha 1 -0.217109
CANX calnexin -0.216921
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.215924
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.215924
GLRX5 glutaredoxin 5 -0.211613
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.211295
RUFY1 RUN and FYVE domain containing 1 -0.200941