S0-EE-YAXR_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, 6-Nonylpyridine-2,4-diol, GPR84 agonist;Potent GPR84 Agonists targeting GPR84 (Novartis, 127045422)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/127045422
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Genes

109 genes differentially expressed following the S0-EE-YAXR_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
BUD31 BUD31 homolog (S. cerevisiae) 2.02135
UBC ubiquitin C 1.15908
RPL37A ribosomal protein L37a 1.15502
RPS5 ribosomal protein S5 1.09575
ROMO1 reactive oxygen species modulator 1 1.04543
DDTL D-dopachrome tautomerase-like 1.02579
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.994297
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.994297
RPL18A ribosomal protein L18a 0.965259
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.849796
ATOX1 antioxidant 1 copper chaperone 0.813762
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.746033
RPS15 ribosomal protein S15 0.733984
RPS29 ribosomal protein S29 0.700539
MLF2 myeloid leukemia factor 2 0.686362
S100A6 S100 calcium binding protein A6 0.602585
BLVRB biliverdin reductase B 0.563519
S100A2 S100 calcium binding protein A2 0.559243
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.535955
RPS27 ribosomal protein S27 0.53177
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.529033
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.528944
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.527419
RPLP2 ribosomal protein, large, P2 0.520011
MYL12B myosin, light chain 12B, regulatory 0.512445
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.508406
CDC20 cell division cycle 20 0.494984
RPS7 ribosomal protein S7 0.481177
MFGE8 milk fat globule-EGF factor 8 protein 0.469753
ATP5MF ATP synthase membrane subunit f 0.460096
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.457575
TMEM9 transmembrane protein 9 0.417398
GSTP1 glutathione S-transferase pi 1 0.412418
TNNT1 troponin T type 1 (skeletal, slow) 0.392772
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.355417
MT1E metallothionein 1E 0.347987
APEH acylaminoacyl-peptide hydrolase 0.341822
HMGA1 high mobility group AT-hook 1 0.338539
SSR4 signal sequence receptor, delta 0.335049
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.333738
IFITM3 interferon induced transmembrane protein 3 0.330227
SNU13 small nuclear ribonucleoprotein 13 0.318153
PYCR1 pyrroline-5-carboxylate reductase 1 0.315775
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.313136
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.304968
RPL35A ribosomal protein L35a 0.303061
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.303061
MICALL1 MICAL-like 1 0.298351
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.280358
DISP3 dispatched RND transporter family member 3 0.276619
KCTD15 potassium channel tetramerization domain containing 15 0.267522
MFSD2B major facilitator superfamily domain containing 2B 0.265389
PRDX2 peroxiredoxin 2 0.265389
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.261524
RPL28 ribosomal protein L28 0.256682
CIB1 calcium and integrin binding 1 (calmyrin) 0.256682
ALPL alkaline phosphatase, liver/bone/kidney 0.256682
MAP7D1 MAP7 domain containing 1 0.256682
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.2529
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.252807
WDR46 WD repeat domain 46 0.251325
TMEM258 transmembrane protein 258 0.247478
FBXW5 F-box and WD repeat domain containing 5 0.247478
EIF3G eukaryotic translation initiation factor 3, subunit G 0.246687
BAG6 BCL2-associated athanogene 6 0.246687
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.246053
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.240685
PRAF2 PRA1 domain family, member 2 0.240685
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.234575
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.233207
RPLP0 ribosomal protein, large, P0 0.232654
SHISA5 shisa family member 5 0.230207
SIGMAR1 sigma non-opioid intracellular receptor 1 0.22816
AURKAIP1 aurora kinase A interacting protein 1 0.210906
ZNRD2 zinc ribbon domain containing 2 0.209932
RPL31 ribosomal protein L31 0.207335
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.204009
MTLN mitoregulin 0.201707

decreased expression

Symbol Name Standardized Value
PKM pyruvate kinase, muscle -0.747744
TARDBP TAR DNA binding protein -0.643617
RHOB ras homolog family member B -0.506024
ZNF185 zinc finger protein 185 (LIM domain) -0.478022
TLK2 tousled-like kinase 2 -0.382299
PGK1 phosphoglycerate kinase 1 -0.382182
RPL4 ribosomal protein L4 -0.347926
RPL3 ribosomal protein L3 -0.341822
MCM3 minichromosome maintenance complex component 3 -0.333738
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.31475
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.313136
USP11 ubiquitin specific peptidase 11 -0.30891
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.304968
EIF3B eukaryotic translation initiation factor 3, subunit B -0.294291
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -0.289224
HSPA1A heat shock 70kDa protein 1A -0.284663
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.282807
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.265389
ASRGL1 asparaginase like 1 -0.25377
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.246291
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.242777
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.240718
FTH1 ferritin, heavy polypeptide 1 -0.239461
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.239174
SRSF9 serine/arginine-rich splicing factor 9 -0.235517
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.233404
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.228452
ARF6 ADP-ribosylation factor 6 -0.22816
DCXR dicarbonyl/L-xylulose reductase -0.225075
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.218446
RPL10L ribosomal protein L10-like -0.214668