| Dataset | NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles |
| Category | transcriptomics |
| Type | drug perturbation |
| Description | Dose=0.01uM, [3-[[4-(aminomethyl)-1-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate, LIMK2 gene inhibitor;LIMK1 gene inhibitor targeting LIMK1, LIMK2 (Novartis, 127047919) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/127047919 |
| Similar Terms | |
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66 genes differentially expressed following the S0-EE-YRH3_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS14 | ribosomal protein S14 | 1.98463 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 1.20923 |
| RPL37A | ribosomal protein L37a | 0.869763 |
| RPS29 | ribosomal protein S29 | 0.749548 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | 0.518341 |
| RPS27 | ribosomal protein S27 | 0.477097 |
| RPS16 | ribosomal protein S16 | 0.476424 |
| ROMO1 | reactive oxygen species modulator 1 | 0.446727 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.446562 |
| RPL18A | ribosomal protein L18a | 0.44329 |
| UBC | ubiquitin C | 0.436909 |
| RPL38 | ribosomal protein L38 | 0.435351 |
| NDUFA9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | 0.435351 |
| NDUFB10 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa | 0.430667 |
| S100A2 | S100 calcium binding protein A2 | 0.424286 |
| SPRR2D | small proline-rich protein 2D | 0.416895 |
| RPLP2 | ribosomal protein, large, P2 | 0.412195 |
| C19ORF33 | chromosome 19 open reading frame 33 | 0.383531 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.355366 |
| MRPL52 | mitochondrial ribosomal protein L52 | 0.325315 |
| RPLP1 | ribosomal protein, large, P1 | 0.308086 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | 0.268001 |
| RPS5 | ribosomal protein S5 | 0.253239 |
| RPL18 | ribosomal protein L18 | 0.236873 |
| ATOX1 | antioxidant 1 copper chaperone | 0.234169 |
| MLF2 | myeloid leukemia factor 2 | 0.229146 |
| RPL35A | ribosomal protein L35a | 0.219644 |
| ATP5MF | ATP synthase membrane subunit f | 0.215244 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.209045 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | 0.208105 |
| BUD31 | BUD31 homolog (S. cerevisiae) | 0.205932 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNI | cyclin I | -1.00536 |
| ACO2 | aconitase 2, mitochondrial | -0.841864 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.753962 |
| ADI1 | acireductone dioxygenase 1 | -0.459331 |
| ARF6 | ADP-ribosylation factor 6 | -0.459331 |
| MOSPD3 | motile sperm domain containing 3 | -0.45291 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.446562 |
| MCM3 | minichromosome maintenance complex component 3 | -0.436131 |
| PPME1 | protein phosphatase methylesterase 1 | -0.417258 |
| POTEF | POTE ankyrin domain family, member F | -0.414862 |
| PKM | pyruvate kinase, muscle | -0.352922 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | -0.350433 |
| SRSF2 | serine/arginine-rich splicing factor 2 | -0.333929 |
| SFSWAP | splicing factor, suppressor of white-apricot family | -0.313993 |
| GNAS | GNAS complex locus | -0.313993 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.304394 |
| JPH3 | junctophilin 3 | -0.299842 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | -0.297152 |
| HAUS8 | HAUS augmin-like complex, subunit 8 | -0.284068 |
| ERH | enhancer of rudimentary homolog (Drosophila) | -0.28146 |
| PNO1 | partner of NOB1 homolog (S. cerevisiae) | -0.264832 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.247937 |
| ERLIN1 | ER lipid raft associated 1 | -0.245974 |
| USP22 | ubiquitin specific peptidase 22 | -0.241986 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.240442 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.240323 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.240276 |
| TLN1 | talin 1 | -0.239035 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.230968 |
| SELENOS | selenoprotein S | -0.223953 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.215244 |
| ADAR | adenosine deaminase, RNA-specific | -0.215244 |
| MAGED1 | melanoma antigen family D1 | -0.215244 |
| GPAT4 | glycerol-3-phosphate acyltransferase 4 | -0.215244 |
| ARMC10 | armadillo repeat containing 10 | -0.201 |
