S0-EE-YRH3_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, [3-[[4-(aminomethyl)-1-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate, LIMK2 gene inhibitor;LIMK1 gene inhibitor targeting LIMK1, LIMK2 (Novartis, 127047919)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/127047919
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Genes

67 genes differentially expressed following the S0-EE-YRH3_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RPS14 ribosomal protein S14 1.54459
RPL18A ribosomal protein L18a 1.07433
MLF2 myeloid leukemia factor 2 0.944338
BUD31 BUD31 homolog (S. cerevisiae) 0.944338
S100A2 S100 calcium binding protein A2 0.914316
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.855269
RPS27 ribosomal protein S27 0.84616
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.82507
RPS15 ribosomal protein S15 0.794057
RPL37A ribosomal protein L37a 0.794057
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.782885
RPL18 ribosomal protein L18 0.75209
RPLP2 ribosomal protein, large, P2 0.70773
ROMO1 reactive oxygen species modulator 1 0.703335
UBC ubiquitin C 0.600368
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.58503
RPLP0 ribosomal protein, large, P0 0.582455
GSTP1 glutathione S-transferase pi 1 0.555251
ATOX1 antioxidant 1 copper chaperone 0.525413
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.522751
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.517415
RPS29 ribosomal protein S29 0.507735
RPLP1 ribosomal protein, large, P1 0.446066
RPS3 ribosomal protein S3 0.412723
RPL35A ribosomal protein L35a 0.409433
C19ORF33 chromosome 19 open reading frame 33 0.399978
HDGF hepatoma-derived growth factor 0.381345
CRYAB crystallin, alpha B 0.380744
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.352808
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.329546
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.319122
PTGES2 prostaglandin E synthase 2 0.285028
RPL38 ribosomal protein L38 0.276943
ECI1 enoyl-CoA delta isomerase 1 0.264324
RPS16 ribosomal protein S16 0.262489
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.250414
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.249035
RPS18 ribosomal protein S18 0.247807
SSR4 signal sequence receptor, delta 0.241185
KISS1 KiSS-1 metastasis-suppressor 0.238938
SLTM SAFB-like, transcription modulator 0.235922
BLVRB biliverdin reductase B 0.230403
SNX8 sorting nexin 8 0.224536
EIF6 eukaryotic translation initiation factor 6 0.224536
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.222054
PTRH2 peptidyl-tRNA hydrolase 2 0.218473
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 0.217455
NF2 neurofibromin 2 (merlin) 0.212345
METRN meteorin, glial cell differentiation regulator 0.203652
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.201623
SPANXB1 SPANX family, member B1 0.201623
HSPB1 heat shock 27kDa protein 1 0.201504
FIBP fibroblast growth factor (acidic) intracellular binding protein 0.200444

decreased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.562903
PIF1 PIF1 5'-to-3' DNA helicase -0.372383
RXYLT1 ribitol xylosyltransferase 1 -0.352808
SP100 SP100 nuclear antigen -0.338488
SENP1 SUMO1/sentrin specific peptidase 1 -0.295643
TLN1 talin 1 -0.285028
YBX1 Y box binding protein 1 -0.285028
PRC1 protein regulator of cytokinesis 1 -0.272607
DOLPP1 dolichyldiphosphatase 1 -0.259945
HMGB1 high mobility group box 1 -0.250414
BROX BRO1 domain and CAAX motif containing -0.250414
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.250414
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.204799
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.202114