S0-EE-YRH3_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, [3-[[4-(aminomethyl)-1-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate, LIMK2 gene inhibitor;LIMK1 gene inhibitor targeting LIMK1, LIMK2 (Novartis, 127047919)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/127047919
Similar Terms
Downloads & Tools

Genes

25 genes differentially expressed following the S0-EE-YRH3_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
ROMO1 reactive oxygen species modulator 1 0.327174
RPS15 ribosomal protein S15 0.321539
ATOX1 antioxidant 1 copper chaperone 0.321539
LGALS1 lectin, galactoside-binding, soluble, 1 0.305083
TIMP1 TIMP metallopeptidase inhibitor 1 0.291392
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.278406
RPS18 ribosomal protein S18 0.27131
C19ORF33 chromosome 19 open reading frame 33 0.265573
PHPT1 phosphohistidine phosphatase 1 0.265573
C12ORF57 chromosome 12 open reading frame 57 0.251821
RPS16 ribosomal protein S16 0.251821
UBC ubiquitin C 0.245255
RPS5 ribosomal protein S5 0.241654
RPL35 ribosomal protein L35 0.241654
MRPL52 mitochondrial ribosomal protein L52 0.241654
RPL18 ribosomal protein L18 0.241654
RPS29 ribosomal protein S29 0.235438
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.235438
ELOB elongin B 0.227281
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.223345
RPL36 ribosomal protein L36 0.218898
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.212312
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.211533

decreased expression

Symbol Name Standardized Value
PSD4 pleckstrin and Sec7 domain containing 4 -0.238019
EIF1 eukaryotic translation initiation factor 1 -0.204787